Influence of High-Altitude Residential History on Optimal HbA1c Cutoff for Detecting Abnormal Glucose Metabolism.

To explore the influence of recent high-altitude residential history on the optimal cutoff of glycosylated hemoglobin (HbA1c) for detecting abnormal glucose metabolism. The study included 505 self-reported healthy Han participants of age 18-65 years, recruited in Chengdu and categorized based on recent (within 3 months) high-altitude (>2,500 m) residential history. The 1999 WHO criteria was used as the gold standard for defining prediabetes and diabetes.

Accuracy of FreeStyle Libre flash glucose monitoring in patients with type 2 diabetes who migrated from highlands to plains.

Background: The FreeStyle Libre flash glucose monitoring (FGM) system entered the Chinese market in 2017 to complement the self-monitoring of blood glucose. Due to its increased usage in clinics, the number of studies investigating its accuracy has increased. However, its accuracy has not been investigated in highland popu-lations in China.

Age at menopause was not associated with microvascular complications in patients with type 2 diabetes mellitus.

This study aimed to determine whether there is an association between the age at menopause (AM) and diabetic microvascular complications. This cross-sectional study included 298 postmenopausal women with type 2 diabetes mellitus. They were divided into 3 groups according to AM (in years; group 1: AM < 45 years, n = 32; group 2:45 ≤ AM < 50 years, n = 102; group 3: AM ≥ 50 years, n = 164).

[Change of Hepcidin in Patients with Iron Overload at the Tibet Plateau].

Objective: To explore the possible etiological factors of iron overload through detecting plasma hepcidin level of adult males at Tibet plateau.

Methods: 81 Tibetan male adult patients hospitalized in our department during January 2017 - December 2018 were selected, and divided into iron overload group and non-iron overload group. The difference in serum ferritin, serum iron, total iron binding capacity, hemoglobin, HBSAg, ALT, AST, albumin, creatinine and hepcidin of patients in each group were tested.

[Analysis of HFE and Non-HFE Mutations in a Tibet Cohort with Iron Overload].

Objective: The explore the molecular basis of iron-overload in Tibet nationality population of Tibet.

Methods: The inpatients with iron-overload in our department from Dec. 1st 2014 to Jul.

Combating Superbug Without Antibiotic on a Postamputation Wound in a Patient with Diabetic Foot.

Diabetic foot is a kind of limb- and life-threatening complication that is difficult to treat with conventional therapy, especially when accompanied with peripheral arterial insufficiency and severe infection. We present a diabetic patient with a postamputation wound infected by multidrug-resistant Acinetobacter baumannii/haemolyticus, which was resistant to almost all antibiotics. As the clinical response to antimicrobial therapy was poor, antibiotic was discontinued.

[Research progress on role of microRNA in healing of diabetic wound].

Objective: To review the regulatory effect of microRNA (miRNA) in wound healing, which abnormal expression associates with diabetes.

Methods: The literature on miRNA associating with wound healing was reviewed and summarized.

Results: miRNA plays a key role in wound healing, including regulating inflammation, angiogenesis, granulation tissue formation, and re-epithelization.