A novel therapeutic strategy utilizing EpCAM aptamer-conjugated gemcitabine for targeting bladder cancer and cancer stem cells.

Gemcitabine (GEM) is a first line chemotherapy drug for bladder cancer (BCa). GEM's lack of specificity has led to disadvantages, resulting in low efficiency, especially when combined with the targeted treatment of BCa stem cells (CSCs), which is considered the cause of BCa recurrence and progression. To enhance the anti-cancer effect and reduce the side effects of GEM targeting of BCa cells/CSCs, an aptamer drug conjugate (ApDC) targeted delivery system was used to improve the efficiency of GEM in BCa therapy using EpCAM aptamer-GEM conjugates based on the epithelial cell adhesion molecule (EpCAM), which is highly expressed on the cell membrane of BCa cells/CSCs.

The Application of Complexity Analysis in Brain Blood-Oxygen Signal.

One of the daunting features of the brain is its physiology complexity, which arises from the interaction of numerous neuronal circuits that operate over a wide range of temporal and spatial scales, enabling the brain to adapt to the constantly changing environment and to perform various cognitive functions. As a reflection of the complexity of brain physiology, the complexity of brain blood-oxygen signal has been frequently studied in recent years. This paper reviews previous literature regarding the following three aspects: (1) whether the complexity of the brain blood-oxygen signal can serve as a reliable biomarker for distinguishing different patient populations; (2) which is the best algorithm for complexity measure? And (3) how to select the optimal parameters for complexity measures.