Publications by authors named "Shuyan Shen"
Objective: This study assessed CLDN16 as a potential replacement or improvement biomarker for papillary thyroid cancer (PTC), addressing the limitations associated with the prevalently used BRAF-V600E mutation.
Design: Database analyses, tissue validation, RNA sequencing, and functional assays were conducted to evaluate CLDN16 as a PTC biomarker and its clinical application.
Methods: CLDN16 expression was examined in PTC and normal thyroid/para-tumor tissues and compared across various cancer types.
Article Synopsis
- Observational studies indicate a possible link between the gut microbiome and respiratory diseases, but the exact causality is still undetermined.
- Researchers utilized GWAS data from the FinnGen collaboration and MiBioGen consortium, performing a Two-sample Mendelian randomization analysis to explore potential causal relationships between gut microbes and respiratory conditions.
- The study identified 88 associations, confirming three significant causal links: genus Holdemanella as a risk factor for COPD, FamilyXIII as a protective factor against COPD, and genus Oxalobacter as a risk factor for asthma, highlighting the importance of the gut-lung axis in respiratory health.