Publications by authors named "Shuyan Pang"
The relationship of beat-to-beat blood pressure variability (BPV) with prognosis after mechanical thrombectomy (MT) is unclear. Consecutive patients with acute ischemic stroke with large vessel occlusion treated with and without MT matched 1:1 by age, sex, and National Institutes of Health Stroke Scale were included. Beat-to-beat BPV was calculated for both systolic (SBP) and diastolic blood pressure (DBP) as standard deviation, coefficient of variation, successive variation (SV), and average real variability (ARV) at 24-72 h after MT.
View Article and Find Full Text PDFBackground: Blood-brain barrier (BBB) disruption after stroke is closely associated with brain tissue edema and neuronal injury, which requires accurate assessment. However, there is a lack of appropriate BBB imaging modality in vivo. As albumin in the blood could cross the damaged BBB into brain tissue after stroke, it serves as a biomarker for BBB disruption.
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- The study investigates how the Fibrosis-4 (FIB-4) index, a biomarker for liver fibrosis, affects functional outcomes in patients with acute ischemic stroke (AIS) after receiving intravenous thrombolysis (IVT).
- Researchers analyzed data from 1135 AIS patients treated with IVT from 2015 to 2022, finding that higher FIB-4 scores are linked to poorer functional outcomes at 3 months post-treatment, particularly among those with dyslipidemia.
- An individualized prediction model based on the FIB-4 index showed strong predictive ability for assessing outcomes in patients with dyslipidemia, indicating it could be a useful tool for clinicians to identify patients at risk for poor recovery after
Background: Disruption of the blood-brain barrier (BBB) is a major contributor to hemorrhagic transformation (HT) in patients with acute ischemic stroke (AIS) following intravenous thrombolysis (IVT). However, the clinical therapies aimed at BBB protection after IVT remain limited.
Methods: One hundred patients with AIS who underwent IVT were enrolled (42 with HT and 58 without HT 24 h after IVT).
Article Synopsis
- Real-time feedback on collateral circulation and revascularization is essential for developing effective post-stroke treatment strategies.
- The new probe, IR-808AC, improves upon existing NIR-II probes by enhancing excretion and reducing background signals, allowing for better visualization of cerebral vessels.
- This study demonstrates the potential of IR-808AC for continuous monitoring of vascular changes and its effectiveness in assessing revascularization after stroke interventions.
Background: Generalized convulsive epilepsy (GCE), an important subtype of epilepsy, is a syndrome of neuronal dysfunction characterized by diffuse abnormal discharge of neurons within the brain. Compounding evidence suggests a correlation between epilepsy and inflammatory factors, for instance, cyclooxygenase-2, interleukin-1β, and interleukin-6. Elevated levels of inflammatory factors have been observed in patients with epilepsy and several animal models.
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