Hormonomics profiles revealed the mechanisms of cold stratification in breaking the dormancy during seed germination and emergence process of Polygonatum sibiricum Red.

Red, known as Huangjing in Chinese, is a perennial plant valued in traditional Chinese medicine and is a nutritional food ingredient. With increasing market demand outpacing wild resource availability, cultivation has become essential for sustainable production. However, the cultivation of is challenged by the double dormancy characteristics of seeds, which include embryo and physiological dormancy.

Predicting the risk category of thymoma with machine learning-based computed tomography radiomics signatures and their between-imaging phase differences.

The aim of this study was to develop a medical imaging and comprehensive stacked learning-based method for predicting high- and low-risk thymoma. A total of 126 patients with thymomas and 5 patients with thymic carcinoma treated at our institution, including 65 low-risk patients and 66 high-risk patients, were retrospectively recruited. Among them, 78 patients composed the training cohort, while the remaining 53 patients formed the validation cohort.

Shape-Regulated Motion and Energy Conversion of Polyelectrolyte Membrane Actuators.

Smart actuators hold great potential in soft robotics and sensors, but their movement at the fluid interface is less understood and controlled, hindering their performances and applications in complicated fluids. Here an ethanol-containing polyelectrolyte actuator is prepared that demonstrates excellent actuating performance via the Marangoni effect. These actuators exhibit enduring (17 min), repeatable (50 cycles), and autonomous motion on the water surface.

SPINK5 inhibits esophageal squamous cell carcinoma metastasis via immune activity.

Background: Esophageal squamous cell carcinoma (ESCC) is a predominant subtype of esophageal cancer with relatively high mortality worldwide. Serine peptidase inhibitor Kazal-type 5 (SPINK5) is reported to be downregulated in ESCC. However, its explicit role in ESCC remains further investigation.

Ectopic Expression of TIGIT in Lung Adenocarcinoma and Its Clinical Significance.

This study aimed to investigate the T cell immunoreceptor with ITIM and Ig domains (TIGIT) expression in lung adenocarcinoma (LUAD). TIGIT expression was measured by western blot, reverse transcription quantitative polymerase chain reaction. Seventy-two paired surgical specimens were collected from patients with stage I-IV LUAD.

The E3 ubiquitin ligase RNF135 modulates chemotherapy resistance to oxaliplatin for colorectal cancer by modulating autophagy.

Background: RING finger protein 135 plays an important role in tumorigenesis and is associated with drug resistance.

Methods: Bioinformatics analysis showed that RNF135 was significantly differentially expressed in colorectal cancer. RT-qPCR and western blot were used to detect the expression of RNF135.

Whole β-glucan particle attenuates AOM/DSS-induced colorectal tumorigenesis in mice inhibition of intestinal inflammation.

Yeast β-glucan is a polysaccharide purified from cell wall, and its multiple biological activities are essential for immune regulation. However, the effect of β-glucan on the intestinal immune response during colitis-associated colorectal cancer (CAC) is unclear. Here, we explore the possible role of β-glucan in the development of CAC.

The use of the mean computed-tomography value to predict the invasiveness of ground-glass nodules: A meta-analysis.

The invasiveness of ground-glass nodules (GGNs) is difficult to characterize through morphological examination. Multiple studies have independently detected a close relationship between mean computed tomography value and invasiveness of GGNs, however, their relative diagnostic accuracy is uncertain. Here, we performed a meta-analysis to validate whether the mean computed tomography value can predict the invasiveness of GGNs.

Seasonal variations, temperature dependence, and sources of size-resolved PM components in Nanjing, east China.

Size-segregated ambient particulate matter (PM) samples were collected seasonally in suburban Nanjing of east China from 2016 to 2017 and chemically speciated. In both fine (< 2.1 µm, PM) and coarse (> 2.

Differential expression of Tim3 protein in colorectal cancer associated with MSI and Braf mutation.

Tim3 is a negative immune checkpoint molecule and plays a crucial part in tumor-induced immune suppression. Tim3 is a cell surface molecule expressed on T cells marking dysfunctional CD8+ cells in various kinds of cancers. Tim3 expression was mainly reported in tumor-infiltrating lymphocytes (TILs).

Efficacy of afatinib in a patient with rare EGFR (G724S/R776H) mutations and amplification in lung adenocarcinoma: A case report.

Background: The most common mutations are in-frame deletions in exon 19 and point mutations in exon 21. Cases with classical mutations show a good response to EGFR tyrosine kinase inhibitors (TKIs), the standard first-line treatment. With the development of next generation sequencing, some uncommon genomic mutations have been detected.

NLK interacts with 14‑3‑3ζ to restore the expression of E‑cadherin.

The Nemo‑like kinase (NLK), a conserved serine/threonine kinase, plays a critical role in the regulation of a variety of transcription factors, with important roles in determining cell fate. Although recent studies have demonstrated decreased expression patterns of NLK in various types of human cancer, the functional mechanism of NLK in cancer development has not been elucidated. Here, in the present study overexpression of NLK was found to inhibit the growth and migration of the non‑small cell lung cancer A549 cell line.

PM elements at an urban site in Yangtze River Delta, China: High time-resolved measurement and the application in source apportionment.

Elemental concentrations of ambient aerosols are commonly sampled over 12-24 h, and the low time resolution puts a great limit on current understanding about the temporal variations and source apportionment based on receptor models. In this work, hourly-resolved concentrations of eighteen elements in PM at an urban site in Nanjing, a megacity in Yangtze River Delta of east China, were obtained by using a Xact 625 ambient metals monitor from 12/12/2016 to 12/31/2017. The influence of traffic activities was clearly reflected by the spikes of crustal elements (e.

Characteristics of heterotrophic nitrification and aerobic denitrification bacterium Acinetobacter sp. T1 and its application for pig farm wastewater treatment.

A novel heterotrophic bacterium was isolated from activated sludge of a pig farm wastewater treatment plant and identified as Acinetobacter sp. T1. It exhibited efficient heterotrophic nitrification and aerobic denitrification capability to utilize ammonium, nitrate or nitrite as the sole nitrogen source, and their removal rates were 12.