Publications by authors named "Shuya Kandori"

Background: To investigate variations in diagnostic performance of photodynamic diagnosis (PDD) according to surgical experience.

Methods: Data were extracted from patients having pT1 or lower primary tumors that underwent PDD-assisted transurethral resection of bladder tumors (TURBT) with orally 5-amibolevulinic acid at our institute. Surgical experience was categorized by urological experience (first-year and second-year) and PDD experience (<10, 10-19, and ≥20 cases).

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Nivolumab plus ipilimumab (NIVO+IPI) has a long-term response rate of 30% for patients with metastatic renal cell carcinoma (mRCC). However, 20% of patients develop primary resistant disease (PRD) to NIVO+IPI and show poor survival outcomes. In this study, we aimed to evaluate the effect of PRD as a second-line treatment in patients with mRCC.

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The tumor microenvironment (TME) modulates therapeutic response and prognosis in patients with bladder cancer (BC). The roles of two phospholipase D (PLD) isoforms, PLD1 and PLD2 (hydrolysis of phosphatidylcholine to phosphatidic acid), in cancer cells have been well-studied in numerous cancer types, but their roles in the TME remain unclear. We used a mouse BC Pld2-KO carcinogenesis model and global transcriptomic analysis to reveal that PLD2 was significantly involved in BC progression through immunosuppressive pathways in the TME.

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Medical illustration serves as a cornerstone for understanding intricate anatomical anomalies, with three-dimensional (3D) rendering emerging as a pioneering tool for emphasizing basic medical concepts and clinical practices. In Japan, the SYNAPSE VINCENT software package (SVSP; Fujifilm Medical Co., Ltd.

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Objectives: Mediastinal germ cell tumors are rare and few large-scale studies on mediastinal germ cell tumors are reported. We aimed to investigate the clinical characteristics and survival outcomes of patients with mediastinum germ cell tumors in Japan.

Methods: A hospital-based cancer registry data in Japan was used to identify and enroll patients diagnosed with mediastinal germ cell tumors in 2012-2013.

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Article Synopsis
  • Combination therapy of nivolumab and ipilimumab (NIVO + IPI) has shown effectiveness in treating metastatic renal cell carcinoma (mRCC), but about 20% of patients progress early, highlighting the need for predictive biomarkers.
  • A study found that certain tumor microenvironment (TME) gene expressions could serve as predictive biomarkers, accurately distinguishing between patients who respond to treatment and those who do not, with high sensitivity and specificity.
  • Further analysis indicated that tumors with high expression levels of this gene activated an adaptive immune response, suggesting that inhibiting both PD-1 and CTLA-4 may enhance treatment effectiveness by improving immune cell actions against tumors.
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Case 1 : A 75-year-old man was emergently admitted to our hospital with a complaint of continuous bleeding from the ileal conduit. The conduit was constructed by a total pelvic resection for sigmoid colon cancer that invaded the urinary bladder 24 years ago. Swollen cutaneous mucosa was seen around the ileal conduit, but no obvious bleeding spot was observed.

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Purpose: To investigate whether seminal plasma (SP)/serum ratios of multiple trace elements (TEs) can classify patients with male subfertility.

Methods: SP/serum ratios of 20 TEs (lithium, sodium, magnesium, phosphorus, sulfur, potassium, calcium, manganese, iron, cobalt, copper, zinc, arsenic, selenium, rubidium, strontium, molybdenum, cesium, barium, and thallium) were calculated for healthy volunteers ( = 4) and those consulting for male subfertility ( = 245). Volunteer semen samples were collected by split ejaculation into early and subsequent fractions, and SP/serum ratio data were compared between fractions.

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  • This study compared the effectiveness of two second-line treatments, cabozantinib and axitinib, for patients with metastatic clear cell renal cell carcinoma (ccRCC) who previously received nivolumab-ipilimumab therapy.
  • A total of 48 patients were treated with cabozantinib and 60 with axitinib, revealing a median progression-free survival (PFS) of 11.0 months for cabozantinib and 9.5 months for axitinib, with overall response rates being quite similar (37.5% vs. 38.3%).
  • Although both treatments had comparable safety profiles, cabozantinib showed improved efficacy in patients considered to have poor-risk characteristics, suggesting it
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Background/aim: While post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) benefits patients with teratoma or viable germ cell tumors (GCT), it becomes overtreatment if necrosis is detected in PC-RPLND specimens. Serum microRNA-371a-3p correctly predicts residual viable GCT with 100% sensitivity; however, prediction of residual teratoma in PC-RPLND specimens using current modalities remains difficult. Therefore, we developed a machine learning model using CT imaging and clinical variables to predict the presence of residual teratoma in PC-RPLND specimens.

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  • The study examines the diagnostic accuracy of cystoscopy, highlighting how it varies based on the experience of the physician conducting the procedure.
  • Researchers compared eye movement patterns of 24 medical students and 10 urologists while observing cystoscopic images, focusing on their ability to detect lesions, especially with the help of artificial intelligence (AI).
  • Results showed that urologists had a broader and more efficient gaze across images, indicating better lesion identification skills, while medical students were more focused on AI-detected lesions, suggesting differences in their observational strategies.
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Background: Identification of patient subclasses that correlate with the diagnostic performance of photodynamic diagnostic (PDD)-assisted transurethral resection of bladder tumors (TURBT) may improve outcomes.

Methods: Data were extracted from patients that underwent PDD-assisted TURBT at the University of Tsukuba Hospital between 2018 and 2023. Sensitivity and specificity were evaluated based on PDD findings (excluding WL findings) and pathology results.

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Bladder cancer is one of the most common cancers among men worldwide. Although multiple genomic mutations and epigenetic alterations have been identified, an efficacious molecularly targeted therapy has yet to be established. Therefore, a novel approach is anticipated.

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Objectives: We sought clinical characteristics, survival outcomes, and prognostic factors for overall survival of retroperitoneal sarcoma in Japan.

Methods: A Japanese hospital-based cancer registry database with a pivotal 10-year follow-up was used to identify and enroll patients, registered from 106 institutions, diagnosed with retroperitoneal sarcoma in 2008-2009. Treating hospitals were divided by hospital care volume; high-volume hospitals and low-volume hospitals were defined as ≥ 4 and < 4 cases/year, respectively.

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Background: Genitourinary sarcomas are rare in adults and few large-scale studies on adult genitourinary sarcoma are reported. We aimed to elucidate the clinical characteristics, survival outcomes, and prognostic factors for overall survival of adult genitourinary sarcoma in Japan.

Methods: A hospital-based cancer registry data in Japan was used to identify and enroll patients diagnosed with genitourinary sarcoma in 2013.

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Background: To identify the prognostic impact of treatment centralization in patients with testicular germ cell tumors (TGCT).

Methods: We used a hospital-based cancer registry data in Japan to extract seminoma and non-seminoma cases that were diagnosed in 2013, histologically confirmed, and received the first course of treatment. To compare the 5-years overall survival (OS) rates of patients stratified by institutional care volume, we performed a Cox proportional hazards regression analysis using inverse probability of treatment weighting (IPTW) method to adjust patient backgrounds.

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  • The study evaluated the outcomes for patients with metastatic renal cell carcinoma (mRCC) who received second-line targeted kinase inhibitors (TKIs) after first-line immunotherapy (IO), comparing different therapy groups.
  • A total of 243 mRCC patients were analyzed, revealing similar response rates and progression-free survival (PFS) periods between the two therapy groups, indicating no significant differences in outcomes.
  • Non-clear cell renal cell carcinoma (non-CCRCC), high C-reactive protein (CRP), and low albumin levels were identified as key independent prognostic factors for poor PFS and overall survival (OS), allowing for the development of a more accurate risk classification system for these patients.
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Objectives: To investigate the efficacy of pharmacotherapy for metastatic non-clear cell renal cell carcinoma (nccRCC) in Japanese population.

Methods: In this retrospective analysis, we compared the time to treatment failure (TTF) for molecular-targeted agents as first-line therapy, or nivolumab therapy as sequential therapy between ccRCC and nccRCC using the data of Japanese metastatic RCC patients registered in the Michinoku Japan Urological Cancer Study Group database.

Results: In total, 511 cases of ccRCC and 77 cases of nccRCC were treated with pharmacotherapy.

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Background: The Modified International Metastatic Renal Cell Carcinoma Dataset Consortium model (mIMDC) is a preoperative prognostic model for pT3cN0M0 renal cell carcinoma (RCC). This study aimed to validate the mIMDC and to construct a new model in a localized and locally advanced RCC (LLRCC).

Methods: A database was established (the Michinoku Japan Urological Cancer Study Group database) consisting of 79 patients who were clinically diagnosed with LLRCC (cT3b/c/4NanyM0) and underwent radical nephrectomy from December 2007 to May 2018.

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Prognoses for patients with metastatic urothelial carcinoma (mUC) have improved with pembrolizumab treatment, an immune checkpoint inhibitor, but clinical benefits are limited to a subset of patients. Therefore, a non-invasive biomarker to predict pembrolizumab response is required. The present study retrospectively examined genomic alterations in 25 plasma circulating tumor DNA (ctDNA) samples using targeted sequencing of 77 genes from 16 patients with mUC during pembrolizumab treatment.

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Enfortumab vedotin (EV) is an antibody-drug conjugate and a promising agent for metastatic urothelial carcinoma (mUC). However, evaluations in end-stage renal disease patients undergoing hemodialysis are unreported. Here, we report such a case.

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