Publications by authors named "Shuxin Zhi"
Molecular mechanism governing RNA-binding property of mammalian TRIM71 protein.
Sci Bull (Beijing)
January 2024
Article Synopsis
- TRIM71 is an RNA-binding protein with functions in cell cycle regulation and stem cell self-renewal, and interacts with the long noncoding RNA Trincr1 to modulate the FGF/ERK signaling pathway in mouse embryonic stem cells.
- The study identifies a specific RNA motif recognized by mTRIM71 in Trincr1 and details the crystal structure of its NHL domain bound to this RNA, highlighting an essential adenosine in the interaction.
- Key amino acid residues in mTRIM71 are identified as crucial for RNA binding, and mutations can hinder its ability to attach to hairpin RNAs and mRNAs linked to cell cycle regulation, providing insights into TRIM71-related
Understanding the mechanism of asymmetric gene regulation determined by the VqmA of vibriophage.
Biochem Biophys Res Commun
June 2021
The quorum-sensing (QS) system between the phages and their hosts is important for the phage lysis-lysogeny decision. In Vibrio cholerae, the QS system consists of a LuxR-type receptor VqmA (VqmA) and an autoinducer molecule 3,5-dimethylpyrazin-2-ol (DPO). A VqmA homolog encoded by vibriophage VP882 (VqmA) can intervene the host QS system via binding to both the host-produced DPO and its cognate promoter (Pqtip) to induce the phage lysogeny-to-lysis transition, whereas VqmA cannot influence the VqmA-induced pathway, suggesting an asymmetry regulation.
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