Ultrasensitive detection of methylene blue by surface-enhanced Raman scattering (SERS) with Ag nanoparticle-decorated magnetic CoNi layered double hydroxides.

The unreasonable use of organic dye leads to excessive residues in environmental water, which seriously threatens human health and the natural environment. In this paper, a spherical flower-like magnetic FeO@CoNi layered double hydroxide@silver nanoparticle (FeO@CoNi LDH@Ag NPs) SERS substrate was successfully fabricated electrostatic self-assembly and applied for the sensitive detection of methylene blue (MB) in environmental water. The rapid concentration and separation of the SERS substrate from the water sample could be achieved using an external magnet.

A core-shell structured AuNPs@ZnCo-MOF SERS substrate for sensitive and selective detection of thiram.

Surface-enhanced Raman scattering (SERS) enables pesticide residue monitoring to become facile and efficient. In this study, a core-shell structured gold nanoparticles@ZnCo metal-organic framework (AuNPs@ZnCo-MOF) SERS substrate was designed and successfully synthesized for efficient and selective detection of thiram. The bimetallic ZnCo-MOF shell can not only enrich the targeted molecules in the electromagnetic field because of its excellent absorptive capacity, but also act as a stabilized matrix for protecting the AuNPs from aggregation.

Efficient extraction based on a polydimethylsiloxane/bimetallic ZnCo-MOF carbonization sponge coupled with GC-MS for the rapid analysis of volatile compounds in cumin.

A novel porous polydimethylsiloxane/bimetallic ZnCo-MOF carbonization (PDMS/ZnCo-MOF@C) sponge was successfully fabricated, followed by its utilization in GC-MS for the high efficiency extraction and determination of volatile compounds in cumin. The PDMS/ZnCo-MOF@C sponge exhibits outstanding properties with a considerable adsorption capacity, high surface area, and large pore volume and has shown potential as an ideal adsorbent for the separation and preconcentration of trace volatile compounds. The effect of different parameters on the extraction efficiency were investigated.

Fabrication of pH/HO-responsive polyhedral oligomeric silsesquioxane self-assembled fluorescent vesicles for enhanced anti-tumor efficacy.

The rational design of a fluorescence imaging-guided, highly efficient multiresponsive delivery system is important for improving drug delivery efficiency. Herein, pH/HO-responsive polyhedral oligomeric silsesquioxane (POSS) molecule functionalized 4-(phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl)amino)benzaldehyde (OTB) copolymer (PEG-POSS-OTB) was synthesized to encapsulate doxorubicin (DOX) for precise drug delivery. The self-assembly fluorescent vesicles exhibited excellent pH/HO-responsive drug release properties under physiological conditions and efficient drug-targeting ability.

MicroRNA-195 reverses the resistance to temozolomide through targeting cyclin E1 in glioma cells.

Glioma is the most common malignant tumor of the central nervous system with poor survival. Temozolomide (TMZ) is the first-line chemotherapy drug for initial and recurrent glioma treatment with a relatively good efficacy, which exerts its antitumor effects mainly through cell death induced by DNA double-strand breaks in the G1 and S phases. However, endogenous or acquired resistance to TMZ limits glioma patients' clinical outcome and is also an important cause of glioma replase.