Publications by authors named "Shuwen Xue"

Polaritons in van der Waals (vdWs) materials enable light-matter interactions at the nanoscale. Polaritonic manipulation is of significance in fundamental physics and various promising nanophotonic applications. Here we study the asymmetric steering of phonon polaritons (PhPs) in hexagonal boron nitride (hBN) based on numerical simulations.

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  • - The study identifies plumbagin as a new inhibitor of TRPV2, a calcium channel important in immune response and neuroinflammation, through various scientific methods such as fluorescence assays and molecular docking.
  • - Plumbagin demonstrates strong selectivity and potency as a TRPV2 inhibitor, reducing the channel's activity without altering its conductance, and effectively mitigating inflammation in microglia and brain injury in mice models.
  • - This research positions TRPV2 as a promising target for treatments focusing on neuroinflammation and conditions like ischemic stroke, with plumbagin serving as a key tool for further exploration in this field.
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Purpose: The high morbidity and mortality associated with type 2 diabetes mellitus (T2DM) pose a significant global health challenge, necessitating the development of more efficient anti-diabetic drugs with fewer side effects. This study investigated the intervention of vitamin D3 combined with glibenclamide in rats with T2DM to elucidate its effects on pancreatic β-cells through the NF-κB pathway.

Methods: Twenty-four healthy male Sprague-Dawley (SD) rats were randomly assigned to four groups: the control group (CG), the model group (MG), the glibenclamide group (GG), and the glibenclamide + vitamin D3 group (GDG).

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  • The study assessed the effectiveness of cell-free DNA (cfDNA) testing for detecting chromosomal abnormalities in multiple pregnancies, specifically twins, triplets, and cases of vanishing twins.
  • Data from 292 pregnancies showed that cfDNA testing was particularly effective for trisomy 21, with a 100% confirmation rate and a 0% false positive rate in twin pregnancies.
  • The research concluded that while cfDNA testing is reliable for assessing trisomy 21 in twin pregnancies, its ability to detect other chromosomal abnormalities is limited due to the small number of cases.
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Biomass combustion for power generation stands as a pivotal method in energy utilization, offering a promising approach for renewable energy utilization. However, the substantial volume of slag produced by biomass burning plants poses environmental challenges, impeding sustainable energy practices. This article systematically studies the characteristics of ash generated from typical biomass direct combustion power plant ash and analyzes the chemical composition, trace element content characteristics, leaching characteristics, and chemical forms of biomass bottom ash.

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  • Scientists are studying how heat treatment (hyperthermia) can help fight nasopharyngeal cancer (NPC) and why some cancer cells resist the heat.
  • They found that using heat with a drug called oridonin makes cancer cells easier to kill, especially the tough ones that don't respond well to regular treatments.
  • The study also discovered that a protein called Cirbp helps cancer cells survive heat, and reducing Cirbp improves the effectiveness of heat treatment against these cancer cells.
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Understanding heavy metal environmental behavior with humic acid (HA) is critical. There is currently a lack of information on the control of its structure organization on its reactivity to metals. The difference in HA structures under non-homogeneous conditions is critical for revealing its micro-interaction with heavy metals.

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  • A recent study investigated whether multiple-site low-pass genome sequencing could enhance the detection of genetic abnormalities in first-trimester miscarriages, particularly focusing on mosaicism.
  • The results showed a significant increase in the diagnostic yield (77.0%) for genetic abnormalities, with 17.0% attributed to mosaicism, especially highlighting the underrecognition of heterogeneously distributed mosaicisms.
  • The study, conducted on 174 patients over three years, used various sampling techniques to analyze genetic compositions, revealing insights into the complexities of genetic causes of early pregnancy loss.
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Ca doping is an effective method for improving the adsorption capacity of HA-Fe aggregates and regulating their structures. Understanding the structural characteristics of Ca-HA-Fe aggregates can help explore their microscopic adsorption effect on heavy metals. However, the heterogeneity of HA results in an incomplete understanding of the structural characteristics of the ternary system of Ca-HA-Fe aggregates and adsorption of the quaternary system of Ca-HA-Fe-Pb/Cu/Cd.

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  • Natural hyperbolic crystals (like α-MoO) and monoclinic crystals (like β-GaO) have gained attention in research but are often studied separately.
  • This study examines the relationship between these materials through transformation optics, offering insights into hyperbolic shear polaritons.
  • The work combines theoretical analysis and numerical simulations, paving the way for future exploration of natural materials.
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The coexistence of organic and inorganic pollutants in industrial wastewater has emerged as a concerning environmental issue worldwide due to the critical levels of biological toxicity of these pollutants. In this context, the present study proposes a sandwich structure of fulvic acid and PMIDA-modified LDHs (FA/PMIDA-LDHs) for the simultaneous removal of Cu and aniline from wastewater. The specific structure was synthesized using a combination of coprecipitation and impregnation methods.

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  • Researchers are exploring the concept of invisibility using transformation optics and artificial metamaterials, but practical applications face challenges due to material requirements and losses.
  • The authors suggest new designs for isotropic and hyperbolic invisibility devices using realistic materials like microwaves and van der Waals materials, addressing material loss in the process.
  • Their method shows promising results through simulations and calculations, potentially allowing for low-cost and practical invisible devices, moving beyond the current limitations in the field.
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Currently, routine genetic investigation for male infertility includes karyotyping analysis and PCR for Y chromosomal microdeletions to provide prognostic information such as sperm retrieval success rate. However, over 85% of male infertility remain idiopathic. We assessed 101 male patients with primary infertility in a retrospective cohort analysis who have previously received negative results from standard-of-care tests.

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  • The study evaluated how genome-wide cfDNA testing for chromosomal abnormalities performed differently when additional findings were reported versus when they were not, using data from pregnant women between 2015-2019.
  • It included 3981 women and found that while the concordance rates for trisomy 21 and 18 were both 100%, there were significant discrepancies in other categories, such as trisomy 13 and sex chromosome aneuploidy.
  • The results showed that not reporting extra findings led to a lower false-positive rate (0.17%) compared to reporting them (0.93%), although there was no change in the no-result rates between the two periods.
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Heavy metals pose a serious threat and damage to ecological health when released into the environment. n-HFP is usually used to remediate soils contaminated with heavy metals, but its ability to solidify heavy metals is limited. FA has good ability to trap heavy metals due to its abundant oxygen-containing functional groups.

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In this Letter, we explore the Cherenkov radiation properties of α-phase molybdenum trioxide (α-MoO). We demonstrate that the asymmetric, forward, and reverse Cherenkov radiation can simultaneously exist by rotating the α-MoO slab at the same working frequency and structure. In addition, thanks to the tunable functionalities of graphene, the conversion of forward and reverse Cherenkov radiation can be actualized by altering the Fermi level of graphene.

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Structural variations (SVs) are various types of the genomic rearrangements encompassing at least 50 nucleotides. These include unbalanced gains or losses of DNA segments (copy number changes, CNVs), balanced rearrangements (such as inversion or translocations), and complex combinations of several distinct rearrangements. SVs are known to play a significant role in contributing to human genomic disorders by disrupting the protein-coding genes or the interaction(s) with cis-regulatory elements.

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  • The paper examines how species populations change due to climate change, using a reaction-diffusion equation to model their evolution in a shifting climate environment.
  • It identifies a key criterion for species persistence based on the approximate top Lyapunov exponent, demonstrating that larger fluctuations in climate shift negatively affect species survival, potentially leading to extinction.
  • The research concludes that while species can withstand mild fluctuations, significant changes in climate speed can make them vulnerable, with only minor fluctuations being harmless if they stay within certain thresholds.
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  • - Antimony (Sb) is a significant pollutant causing major environmental issues, and using sulfate-reducing bacteria (SRB) for bioremediation is seen as a safe and cost-effective way to address it.
  • - A study enriched an Sb-tolerant microbial community from municipal sludge, identifying dominant bacteria and isolating a highly active strain named SRB49 that effectively removes Sb(V) from wastewater.
  • - SRB49 showed the capability to remove 95% of Sb(V) in 48 hours under specific conditions, illustrating the potential for using pure cultures of SRB in environmental cleanup efforts for antimony.
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Itch, a common clinical symptom of many skin diseases, severely impairs the life quality of patients. Nav1.7, a subtype of voltage-gated sodium channels mainly expressed in primary sensory neurons, is responsible for the amplification of threshold currents that trigger action potential (AP) generation.

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Pseudomonas aeruginosa DN1 can efficiently utilize fluoranthene as its sole carbon source, and the initial reaction in the biodegradation process is catalyzed by a ring-hydroxylating dioxygenase (RHD). To clarify the binding interaction of RHD with fluoranthene in the strain DN1, the genes encoding alpha subunit (RS30940) and beta subunit (RS05115) of RHD were functionally characterized through multi-technique combination such as gene knockout and homology modeling as well as molecular docking analysis. The results showed that the mutants lacking the characteristic alpha subunit and/or beta subunit failed to degrade fluoranthene effectively.

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  • Researchers created Ca-modified FeO nanoparticles encapsulated in humic acid (HA-Ca/FeO) using a co-precipitation method, and tested how well they adsorb heavy metals like Pb, Cu, and Cd from wastewater.
  • The study found that HA-Ca/FeO exhibited high adsorption capacities, effectively removing up to 99% of Pb and around 91% of Cu and Cd, while also analyzing the mechanisms involved in the adsorption process.
  • The nanoparticles maintained their effectiveness over multiple cycles of adsorption and desorption, highlighting their potential for practical wastewater treatment applications.
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The research on moisture transfer characteristics and surface crack development of a single lignite particle (SLP) driven by humidity difference is helpful to achieve a better understanding of the fragmentation characteristics of lignite during the moisture transfer process. This is of great significance to the safe operation of a drying system. The characteristics of moisture transfer within SLP driven by humidity difference were studied in different stages.

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Strain sw-1, isolated from 7619-m seawater of the Mariana Trench, was identified as by 16S rRNA gene and whole-genome sequencing. sw-1 was able to efficiently utilize long-chain -alkanes (C-C), but not short- and medium-chain -alkanes (C-C). The degradation rate of C was 91.

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