Publications by authors named "Shuwen Ma"

As a crucial element of proteolysis targeting chimeras (PROTACs), the choice of E3 ubiquitin ligase significantly influences degradation efficacy and selectivity. However, the available arsenal of E3 ligases for PROTAC development remains underexplored, severely limiting the scope of targeted protein degradation. In this study, we identify a non-inhibitory aptamer targeting ZYG11B, a substrate receptor of the Cullin 2-RING ligase complex, as an E3 warhead for targeted protein degradation.

View Article and Find Full Text PDF

The development of advanced bifunctional oxygen electrocatalysts for the oxygen reduction reactions (ORR) and oxygen evolution reactions (OER) is crucial for the practical application of zinc-air batteries (ZABs). Herein, porous carbon nanosheets integrated with abundant graphene-wrapped CoO and CoNx (CoO/CoNx-C) were successfully fabricated through a simple one-step pyrolysis. With convenient porous channel and large accessible surface, abundant CoO/CoNx species and graphene wrapping structure, CoO/CoNx-C exhibited a half-wave potential of 0.

View Article and Find Full Text PDF

Freshwater ecosystem is a significant natural source of CH emission in the atmosphere. To fully understand the dynamics of methane emissions in reservoirs, it is essential to grasp the temporal and vertical distribution patterns, as well as the factors that influence the methanogenic bacterial communities within the sediments. This study investigates the methane dynamics, carbon isotope fractionation (δCH), and abundance of functional microorganisms along the geochemical gradient in the in situ sedimentary column of Hongfeng Reservoir (China).

View Article and Find Full Text PDF

The interception of rivers leads to the accumulation of substantial organic matter in reservoirs, exerting a significant influence on greenhouse gas emissions. The diverse imported organic matter, coupled with sedimentary heterogeneity and intricate microbial processes, gives rise to seasonal variations in methane emissions from reservoirs. In this study, sediment cores were supplemented with terrestrial or autochthonous carbon to emulate reservoir carbon input across different seasons, thereby investigating methane emission potential and associated microbial mechanisms within the sediment cores.

View Article and Find Full Text PDF

Significant amounts of the greenhouse gas methane (CH) are released into the atmosphere worldwide via freshwater sources. The surface methane maximum (SMM), where methane is supersaturated in surface water, has been observed in aquatic systems and contributes significantly to emissions. However, little is known about the temporal and spatial variability of SMM or the mechanisms underlying its development in artificial reservoirs.

View Article and Find Full Text PDF

Mulberry is a traditional economic tree with various values in sericulture, ecology, food industry and medicine. Expansins (EXPs) are known as cell wall expansion related proteins and have been characterized to involve in plant development and responses to diverse stresses. In present study, twenty EXP and expansin-like (EXL) genes were identified in mulberry.

View Article and Find Full Text PDF

Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the prolonged and widespread epidemic of coronavirus disease 2019 (COVID-19). The inactivated BBIBP-CorV vaccine has shown safety, efficacy and immunogenicity against COVID-19 in in-vitro studies and clinical trials. However, the characteristics changes of the TCRβ repertoire in patients receiving BBIBP-CorV remain unclear.

View Article and Find Full Text PDF

Introduction: L. root has high nutritional and medicinal values and has been identified as a healthy food raw material by the Ministry of Health of the People's Republic of China.

Methods: In the present study, an aqueous two-phase system (ATPS) of polyethylene glycol (PEG)-(NH)SO was used to extract L.

View Article and Find Full Text PDF

Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and may therefore substitute blood in drug analysis. However, current ISF extraction techniques require bulky instruments and are both time-consuming and complicated, which has inspired the development of viable alternatives such as those relying on skin or tissue puncturing with microneedles. Currently, microneedles are widely employed for transdermal drug delivery and have been successfully used for ISF extraction by different mechanisms to facilitate subsequent analysis.

View Article and Find Full Text PDF

(1) Background: CD163, a specific macrophage receptor, affects the progression of malignant tumors. Unfortunately, the regulation and expression of CD163 are poorly understood. In this study, we determined the expressions of CD163 in TMA samples from CRC patients and combined them with patient data from several Swedish hospitals.

View Article and Find Full Text PDF

Living systems operate far from thermodynamic equilibrium, which usually manifests as broken detailed balance at the molecular scale. At larger scales with collective function of many molecules, the presence of non-equilibrium thermodynamics may not be evident. In bacterial motility, the switching dynamics of the flagellar rotary motor was recently discovered to be operating in non-equilibrium.

View Article and Find Full Text PDF

Background: More and more studies have shown that long non-coding RNA (LncRNA) as a competing endogenous RNA (ceRNA) plays an important role in lung cancer. Therefore, we analyzed the RNA expression profiles of 82 lung cancer patients which were all from Gene Expression Omnibus (GEO).

Methods: Firstly, we used BLASTN (evalue = 1e-10) to annotate the gene sets, performed in-group correction and batched normalization of the three data sets with R.

View Article and Find Full Text PDF

Surface layers (S-layers) are protective protein coats which form around all archaea and most bacterial cells. Clostridium difficile is a Gram-positive bacterium with an S-layer covering its peptidoglycan cell wall. The S-layer in C.

View Article and Find Full Text PDF

Purpose: The role of non-coding RNA, once thought to be dark matter, is increasingly prominent in cancer. Our article explores the effect of non-coding RNA in lung adenocarcinoma and lung squamous cell carcinoma by mining TCGA public database.

Methods: Download the data by applying the official TCGA software.

View Article and Find Full Text PDF

Most membrane proteins exist in complexes that carry out critical cellular functions and exhibit rich dynamics. The bacterial flagellar motor, a large membrane-spanning ion-driven rotary motor that propels the bacteria to swim, provides a canonical example. Rotation of the motor is driven by multiple torque-generating units (stators).

View Article and Find Full Text PDF

Community detection is a challenging task in attributed networks, due to the data inconsistency between network topological structure and node attributes. The problem of how to effectively and robustly fuse multi-source heterogeneous data plays an important role in community detection algorithms. Although some algorithms taking both topological structure and node attributes into account have been proposed in recent years, the fusion strategy is simple and usually adopts the linear combination method.

View Article and Find Full Text PDF

A series of complexes [EtN][Ln(NCS)(HO)] (Ln = Pr, Tb, Dy, Ho, Yb) have been structurally characterized, all showing the same structure, namely a distorted square antiprismatic coordination geometry, and the Ln-O and Ln-N bond lengths following the expected lanthanide contraction. When the counterion is Cs, a different structural motif is observed and the eight-coordinate complex Cs[Nd(NCS)] isolated. The thorium compounds [MeN][Th(NCS)(NO)] and [MeN][Th(NCS)(NO)] have been characterized, and high coordination numbers are also observed.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session86mbhtbj0huo8dg114g6cbpoip5fn98d): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once