Spatiotemporal changes of urban heat island effect relative to land surface temperature: a case study of Jinan City, China.

The urban heat island (UHI) effect has become increasingly prevalent and significant with the accelerated pace of urbanization, posing challenges for urban planners and policymakers. To reveal the spatiotemporal variations of the urban heat island effect in Jinan City, this study utilized Landsat satellite images from 2009, 2014, and 2019, employing the classic Mono-Window algorithm to extract land surface temperature (LST). Additionally, Geodetector was introduced to conduct a detailed analysis of the relationship between LST in Jinan City and land cover types (vegetation, water bodies, and buildings).

Contamination and source apportionment of metals in urban road dust (Jinan, China) integrating the enrichment factor, receptor models (FA-NNC and PMF), local Moran's index, Pb isotopes and source-oriented health risk.

Contamination and source identifications of metals in urban road dust are critical for remediation and health protection. Receptor models are commonly used for metal source identification, whereas the results are usually subjective and not verified by other indicators. Here we present and discuss a comprehensive approach to study metal contamination and sources in urban road dust (Jinan) in spring and winter by integrating the enrichment factor (EF), receptor models (positive matrix factorization (PMF) and factor analysis with nonnegative constraints (FA-NNC)), local Moran's index, traffic factors and Pb isotopes.

Spatial and Temporal Changes of Sand Mining in the Yangtze River Basin since the Establishment of the Three Gorges Dam.

The global demand for sand and gravel is at 50 billion tons per year, far exceeding global resource capacities. It reached 7.6 billion tons in 2021 in the Yangtze River Basin (YRB), China.

Cultivated Land Input Behavior of Different Types of Rural Households and Its Impact on Cultivated Land-Use Efficiency: A Case Study of the Yimeng Mountain Area, China.

Analyzing cultivated land input behavior (CLIB) at the scale of rural households links with cultivated land-use efficiency (CLUE), this study examined the Yimeng Mountain area in northern China, supported by field survey data from 737 rural households. This research systematically analyzed the characteristics of CLIB of different types of rural households, measured the CLUE of different types of rural households by using a data envelopment analysis (DEA) model, and explored the influence of CLIB on CLUE based on the Tobit regression model. The results show (1) significant differences in the characteristics of the CLIB of different types of rural households in the Yimeng Mountain area.

Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway.

Mesenchymal stromal cells (MSCs) have been considered a promising alternative for treatment of acute respiratory distress syndrome (ARDS). However, there is significant heterogeneity in their therapeutic efficacy, largely owing to the incomplete understanding of the mechanisms underlying the therapeutic activities of MSCs. Here, we hypothesize that the cholinergic anti-inflammatory pathway (CAP), which is recognized as a neuroimmunological pathway, may be involved in the therapeutic mechanisms by which MSCs mitigate ARDS.

Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates.

Premature ovarian insufficiency (POI) is defined as the loss of ovarian activity under the age of 40. Theca cells (TCs) play a vital role during folliculogenesis and TCs dysfunction participate in the pathogenesis of POI. Therefore, transplantation of thecal stem cells (TSCs), which are capable of self-renewal and differentiation into mature TCs, may provide a new strategy for treating POI.

Mesenchymal Stromal Cells Rapidly Suppress TCR Signaling-Mediated Cytokine Transcription in Activated T Cells Through the ICAM-1/CD43 Interaction.

Cell-cell contact participates in the process of mesenchymal stromal cell (MSC)-mediated T cell modulation and thus contributes to MSC-based therapies for various inflammatory diseases, especially T cell-mediated diseases. However, the mechanisms underlying the adhesion interactions between MSCs and T cells are still poorly understood. In this study, we explored the interaction between MSCs and T cells and found that activated T cells could rapidly adhere to MSCs, leading to significant reduction of TNF-α and IFN-γ mRNA expression.

Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice.

Pericytes play essential roles in blood-brain barrier (BBB) integrity and dysfunction or degeneration of pericytes is implicated in a set of neurological disorders although the underlying mechanism remains largely unknown. However, the scarcity of material sources hinders the application of BBB models in vitro for pathophysiological studies. Additionally, whether pericytes can be used to treat neurological disorders remains to be elucidated.

Impact of formulary interventions on the minimum inhibitory concentration of methicillin-resistant Staphylococcus aureus to mupirocin, chlorhexidine, and octenidine in a Singapore tertiary institution.

Methicillin-resistant Staphylococcus aureus (MRSA) decolonization is an effective measure to prevent clinical infection but resistance is a concern. We aim to evaluate the impact of mupirocin (MUP) ointment formulary removal, plateauing use of chlorhexidine gluconate (CHG), and hospital-wide introduction of octenidine (OCT)-based products on the minimum inhibitory concentration (MIC) of MRSA to MUP, CHG, and OCT in our hospital. A prevalence study was conducted at three time points (TP) on consecutive MRSA screening isolates to evaluate for their MICs to MUP, CHG, and OCT using broth microdilution sensititre plates and detection of the ileS-2 gene encoding high-level MUP resistance in 2013 (pre-intervention TP1; n = 160), 2016 (early post-intervention TP2; n = 99) and 2017 (late post-intervention TP3; n = 76).

An unusual case of fulminant leptospiral myocarditis: a case report.

Background: Fulminant myocarditis secondary to leptospirosis is rare and associated with poor outcomes.

Case Summary: We describe a 60-year-old gentleman with fulminant leptospiral myocarditis and profound cardiogenic shock requiring veno-arterial extracorporeal membrane oxygenator (VA-ECMO) support. He was given high-dose pulse steroids early on post-VA-ECMO implantation and achieved full recovery.

Invasive Pneumococcal Disease Associated with Fanconi-Like Syndrome.

Unlabelled: Acquired causes of Fanconi syndrome in adults are usually due to drugs, toxins or paraproteinaemias. Infectious causes are rarely described. We report a case of invasive pneumococcal disease in a patient who developed a Fanconi-like syndrome during the course of her illness.

A rare case of CMV pneumonia in HIV-infection.

Cytomegalovirus (CMV) pneumonia is a rare opportunistic infection in the setting of HIV (Human Immunodeficiency Virus)-infection. Establishing accurate diagnosis of CMV pneumonia in HIV-infection can be challenging. Co-infections by multiple opportunistic pathogens are common and a high degree of clinical vigilance to evaluate for multiple infections, including CMV pneumonia, should be maintained.

Human Mesenchymal Stem Cell-Treated Regulatory CD23CD43 B Cells Alleviate Intestinal Inflammation.

Mesenchymal stem cells (MSCs) have been demonstrated to ameliorate inflammatory bowel disease by their actions on multiple immune cells, especially on regulatory B cells (Breg cells). However, the phenotypes and functions of human MSCs (hMSCs)-treated Breg cell subsets are not yet clear. Purified B cells were cocultured with MSCs and the phenotypes and immunomodulatory functions of the B cells were analyzed by FACS and proliferation assays .

Klebsiella Pneumoniae Visceral Organ Abscesses - Clinical Characteristics.

Introduction: In recent years, () has emerged as the predominant cause of pyogenic liver abscess in Asia. - as the causative microorganism in other visceral organ abscesses-is less described. In this study, we seeked to describe the clinical characteristics of visceral organ abscesses in our institution and evaluated the prescription practices of physicians with regard to antibiotic therapy.

An Unusual Case of Mycotic Popliteal Aneurysm Presenting as Recurrent Bacteraemia.

Unlabelled: We describe a patient with a mycotic aneurysm. A 91-year-old man presented with recurrent episodes of bacteraemia 2 months apart. During the second presentation, he underwent magnetic resonance imaging of the left lower limb that revealed rupture of the popliteal artery with a popliteal fossa collection.

Quadruple valve infective endocarditis presenting with suspected Austrian syndrome: a case report and a case series of quadruple valve infective endocarditis.

Objectives: Austrian syndrome comprises the triad of pneumonia, meningitis, and endocarditis secondary to Streptococcus pneumonia. We present what we believe to be the first reported case of Austrian syndrome with quadruple heart valve involvement and review the literature detailing cases of quadruple valve infective endocarditis.

Case Presentation And Results: A case is presented of a patient with radiographic evidence of a left lower lobe pneumonia.

Case Report: Diagnosis of Cryptosporidiosis in Renal Transplantation in a Low-Prevalence Setting.

In high prevalence settings, cryptosporidiosis is commonly implicated as a cause of a gastroenteritis syndrome in the organ transplant population. Stool microscopy is predominant diagnostic modality. Therapeutic options in this group of patients are limited, making their management exceptionally challenging.

The paradoxical evolution in an unusual case of disseminated tuberculosis: Spontaneous resolution with disease progression.

Mycobacterium tuberculosis can cause a myriad of clinical manifestations. We describe a case of a patient with end-stage renal failure, who presented with disseminated tuberculosis over the course of five months, manifesting with a self-resolving mediastinal mass, progressive lymphadenopathy, genitourinary, and musculoskeletal tuberculosis.

Riverbed erosion of the final 565 kilometers of the Yangtze River (Changjiang) following construction of the Three Gorges Dam.

The world's largest hydropower dam, the Three Gorges Dam (TGD), spans the upper Yangtze River in China, creating a 660-km long and 1.1-km wide reservoir upstream. Several recent studies reported a considerable decline in sediment load of the Lowermost Yangtze River (LmYR) and a rapid erosion in the subaqueous delta of the river mouth after the closure of the TGD in 2003.