A novel limonin derivate modulates inflammatory response by suppressing the TLR4/NF-κB signalling pathway.

In our previous studies, we have demonstrated that a novel water-soluble derivative of limonin, (12S,12aS,Z)-8-((2-(diethylamino)ethoxy)imino)-12-(furan-3-yl)-6,6,8a,12a-tetramethyldodecahydro-1H,3H-oxireno[2,3-d]pyrano[4',3':3,3a]isobenzofuro[5,4-f]isochromene-3,10(9aH)-dione (V-A-4), exhibited strong anti-inflammatory activity both in vitro and in vivo. The purpose of this study was to further explore the underlying mechanisms of such activity demonstrated by V-A-4. The protective effect of V-A-4 on the alleviation of xylene-induced ear swelling and carrageenan-induced subcutaneous air pouch model was detected in vivo.

Gene selection approach based on improved swarm intelligent optimisation algorithm for tumour classification.

A number of different gene selection approaches based on gene expression profiles (GEP) have been developed for tumour classification. A gene selection approach selects the most informative genes from the whole gene space, which is an important process for tumour classification using GEP. This study presents an improved swarm intelligent optimisation algorithm to select genes for maintaining the diversity of the population.

Critical Velocity and Dissipation of an Ultracold Bose-Fermi Counterflow.

We study the dynamics of counterflowing bosonic and fermionic lithium atoms. First, by tuning the interaction strength we measure the critical velocity v(c) of the system in the BEC-BCS crossover in the low temperature regime and we compare it to the recent prediction of Castin et al., C.