[Organ-preserving treatment in oncogynecology].

The paper discussed the results of organ-saving treatment carried out in 388 cases of cancer of the cervix uteri (Ca in situ), early endometrial carcinoma and stage IIa tumors of the ovary. The choice of the procedure should be made on reliable evidence on tumor extension and morphology. Favorable end results and preservation of reproductive function justify the use of said treatment and opens up new vistas in research.

[Clinical aspects of a synchronous cancerous lesion of the corpus uteri and the ovaries].

The results of a clinical study of 42 cases of synchronous endometrial and ovarian tumors are discussed. Clinical manifestations of synchronous cancer were found to be similar to those of endometrial carcinoma. Postmenopausal patients showed a favorable course of tumor process, thus suggesting its primary multiple origin, slightly more frequently than reproductive or climacteric females.

[The role of hormone therapy in the treatment of cancer of the endometrium].

Application of 17-oxyprogesterone-capronate as a component of complex treatment of 188 patients with stage I-III carcinoma of corpus uteri improved the long-term results at all stages of the process. Hormonotherapy should be recommended as a method of choice in the postoperative treatment of patients suffering from stage I-II endometrial carcinoma with superficial infiltration of the muscular layer or as an independent method of treatment in elderly patients in case of contraindications for surgery and radiation procedures. The method offers good advantages in young patients at the initial stages only.

[Hemosorption as a method of 5-fluorouracil elimination].

Procedures for removal of 5-fluorouracil from biological fluids by means of ADB-13 ty uncoated activated carbon were studied in vivo and in vitro. Dynamic stand trials showed a high sorptive capacity of carbon which appeared to depend on the rate and duration of perfusion. A 40 min passage through a carbon column at the perfusion rate of 100 ml/min was followed by a 584-fold decrease of the drug concentration.

[Humoral immunity to herpes simplex virus type 2 in cervical cancer].

The analysis of the results of serological studies revealed differences between the number of positively reacting sera from patients with cervical carcinoma and from normal women. The activity of complement-fixing and virus-neutralizing antibodies in the patients' sera and the frequency of their detection were higher than in the sera from normal subjects. These results in combination with other methods of laboratory examinations may be used for early detection of cervical carcinoma as well as for determination of high risk groups with regard to oncological diseases.

[Clinico-morphological changes during treatment of endometrial cancer with progestins].

The results of the complex clinico-morphological study of the effect of 17-a-hydroxyprogesterone-caproate are reported in 71 patients aged from 37 to 75. Stage I was noted in 17 patients, stage II--in 51, stage III--in 3. A total dosage was 5,0; 10,0; 20,0 and 30,0 for the course of treatment.

[Combined and surgical treatment of cervical cancer].

The many-year experience with the treatment of cervical cancer in the gynecological clinic of the P. A. Herzen Research Institute of Oncology has indicated that a combined method in case of the appropriate indications provides for high and persistant late results.