Publications by authors named "Shuting Yao"

Article Synopsis
  • - Mitochondria are essential for how macrophages (a type of immune cell) respond to bacterial infections, and the protein Spns2, which regulates S1P secretion, influences mitochondrial functions in these cells.
  • - Researchers isolated peritoneal macrophages from both normal and Spns2-deficient rats to explore how Spns2/S1P signaling affects mitochondrial functions and inflammation, using techniques like metabolomics, RNA sequencing, and various assays.
  • - The study identifies prostaglandin E (PGE) as a key factor in the communication between Spns2/S1P signaling and mitochondria; a lack of Spns2 leads to high PGE levels that disrupt mitochondrial respiration and cause inflammation-related
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Article Synopsis
  • * The study developed and optimized dendritic polypeptide nanoparticles (DP-AD) for better efficiency and safety in delivering antisense drugs, finding that a lower N/P ratio reduces toxicity without compromising effectiveness.
  • * The optimal formulation identified was DP-AD7 with 10 positive charges, which demonstrated greater antibacterial activity against drug-resistant strains compared to alternatives, thus offering a potential new strategy for treatment.
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In this study, we sequenced and assembled the complete chloroplast genome of Collett ex Hemsl. 1890. The total length of the complete chloroplast sequence was found to be 158,002 bp.

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The combination of phototherapy and chemotherapy has received extensive attention in the field of cancer therapy. Hence, graphene organic framework (GOF) with a large d-spacing was prepared by solvothermal method, and a novel nanocomposite based on bovine serum albumin (BSA) and the anticancer drug doxorubicin (DOX) was developed, which effectively achieved a photothermal-chemotherapy synergistic treatment. When the feeding ratio was 1:1.

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Laser Tweezers Raman Spectroscopy (LTRS) is a combination of laser tweezers and Raman spectroscopy. It is a physical tool based on the mechanical effects of the laser, which can be used to study single living cells in suspension in a fast and non-destructive way. Our work aims to establish a methodology system based on LTRS to rapidly and non-destructively detect the resistance of acute lymphoblastic leukemia (ALL) cells and to provide a new idea for the evaluation of the resistance of ALL cells.

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Marital quality may decrease during the early years of marriage. Establishing models predicting individualized marital quality may help develop timely and effective interventions to maintain or improve marital quality. Given that marital interactions have an important impact on marital well-being cross-sectionally and prospectively, neural responses during marital interactions may provide insight into neural bases underlying marital well-being.

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Recently, nanomaterials have been well-studied in cancer therapy, but some of them often experience difficulties with degradation , which could cause severe damage to the human body. Among numerous biodegradable nanomaterials, antimonene nanosheets (AMNSs) are versatile, and possess photothermal and photodynamic properties and photoacoustic imaging (PAI) and drug loading ability. Herein, we employed a clearable multifunctional system.

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Social-information processing is important for successful romantic relationships and protecting against depression, and depends on functional connectivity (FC) within and between large-scale networks. Functional architecture evident at rest is adaptively reconfigured during task and there were two possible associations between brain reconfiguration and behavioral performance during neurocognitive tasks (efficiency effect and distraction-based effect). This study examined relationships between brain reconfiguration during social-information processing and relationship-specific and more general social outcomes in marriage.

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Multidrug resistance is highly associated with poor prognosis of chronic myeloid leukemia. This work aims to explore whether the laser tweezers Raman spectroscopy (LTRS) could be practical in separating adriamycin-resistant chronic myeloid leukemia cells K562/adriamycin from its parental cells K562, and to explore the potential mechanisms. Detection of LTRS initially reflected the spectral differences caused by chemoresistance including bands assigned to carbohydrates, amino acid, protein, lipids, and nucleic acid.

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The multiple diagnosis and treatment mechanisms of chemotherapy combined with photothermal/photodynamic therapy have very large application prospects in the field of cancer treatment. Therefore, in order to achieve effective and safe antitumour treatment, it is necessary to design an intelligent responsive polymer nanoplatform as a drug delivery system. Herein, the thermosensitive poly-N-isopropylacrylamide (PNIPAM) nanogel particles were prepared by soap-free emulsion polymerization and loaded with a large amount of photosensitizer indocyanine green (ICG) and anticarcinogen 5-fluorouracil (5-Fu), which effectively to realize the cooperative chemotherapy and photothermal/photodynamic therapy for tumours.

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A versatile platform for nanodrug delivery and synergetic therapy is a promising therapeutic pattern for antitumor treatment in clinical biology. Here, we innovatively encapsulated graphene quantum dots (GQDs) or methylene blue (MB) together with doxorubicin (DOX) into the cores of poly lactic-co-glycolic acid (PLGA) nanoparticles coated with bovine serum albumin (BSA) based on the emulsion method to synthesize core-shell structure nanoparticles (GQDs@DOX/PB and MB@DOX/PB NPs). The GQDs@DOX/PB NPs exhibited excellent photothermal properties and stability under 808 nm laser irradiation.

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The antioxidant synergistic effects of Osmanthus fragrans flowers with green tea were evaluated, and their major antioxidant compounds contributed to the total amount of synergy were determined. The antioxidant compounds in O. fragrans flowers with green tea were identified by LC-MS and quantified by UPLC-PDA.

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