Molecular and Cellular Functions of the Linker Histone H1.2.

Linker histone H1.2, which belongs to the linker histone family H1, plays a crucial role in the maintenance of the stable higher-order structures of chromatin and nucleosomes. As a critical part of chromatin structure, H1.

ZGRF1 promotes end resection of DNA homologous recombination via forming complex with BRCA1/EXO1.

To maintain genomic stability, the mammalian cells has evolved a coordinated response to DNA damage, including activation of DNA repair and cell cycle checkpoint processes. Exonuclease 1 (EXO1)-dependent excision of DNA ends is important for the initiation of homologous recombination (HR) repair of DNA breaks, which is thought to play a key role in activating the ATR-CHK1 pathway to induce G2/M cell cycle arrest. But the mechanism is still not fully understood.

Surface modified titania nanotubes containing anti-bacterial drugs for controlled delivery nanosystems with high bioactivity.

Surface functionalization of nanomaterials has been realized to be vital to fabricate drug delivery nanosystems that offer high drug loading and sustained release with remarkable in vivo biocompatibility and bioavailability. From these systems, nanomaterials such as titania nanotubes (TNTs) can be functionalized and designed as specific drug delivery nanosystems. Here, two kinds of novel drug delivery nanosystems, i.

TiO2 nanotubes as animal drug delivery system and in vitro controlled release.

The enrofloxacin hydrochloride (Enro), an anti-inflammatory drug for the animals, was loaded on the TNTs through physical absorption due to the high specific surface area and excellent surface activity of the TiO2 nanotubes. The samples were characterized by XRD, BET, TEM, TG and FTIR. The in vitro controlled release behavior at different temperatures was studied in detail.

Fabrication and photocatalytic activity of TiO2 derived nanotubes with Ag ions doping.

Ag/TiO2 nanotubes with uniform distribution were successfully prepared by a hydrothermal-dipping method. The synthesized samples were characterized by XRD, TEM and FTIR, respectively. The results exhibited that the morphological structure of the TiO2 nanotubes was improved by the doping of Ag ions.

Fabrication of TiO2 nanoparticles loaded on coal fly ash composite with enhanced photocatalytic activity.

By immobilized on the coal fly ashes, the TiO2 nanoparticles photocatalysts were obviously improved in removing organic compounds of the contaminated water. These composite catalysts were fabricated by three different methods involving hydrothermal method, physical blending and sol-gel method. The resulting materials have been characterized by XRD, SEM and FTIR.

Highlighting the possible secondary interactions in the role of balhimycin and its analogues for enantiorecognition in capillary electrophoresis.

It is believed that the enantiorecognition mechanism based on macrocyclic antibiotics involves multimodal interactions via hydrogen bonding, pi-pi interaction, steric hindrance, hydrophobic interaction and so on. A variety of enantiomeric N-benzoylated amino acids were separated using balhimycin (A) or its analogues bromobalhimycin (B) and dechlorobalhimycin (C) as chiral mobile phase additive using a CE method, which combined the partial filling technique with the dynamic coating technique and the co-EOF electrophoresis technique. The enantioresolution and the migration time were highly relevant to the structure of analytes, especially to the substitutions on the N-tagged benzoyl moiety of the amino acids.