Publications by Shutaro Nagano

Publications by authors named "Shutaro Nagano"

Arch Toxicol

December 2024

Thallium (Tl) is a highly toxic heavy metal linked to accidental poisoning and can cause severe health issues including kidney failure.
In a study on rats, intraperitoneal administration of Tl led to significant kidney dysfunction, characterized by high calcium deposits and mitochondrial issues in a specific kidney region called the medullary thick ascending limb (mTAL).
The research found that inhibiting a specific kidney transporter helped reduce Tl accumulation and its damaging effects, which could lead to new treatment strategies for Tl poisoning and improve diagnostic methods for related kidney damage.

Leg Med (Tokyo)

July 2024

* The study found that ATO decreases CAT expression in both rat livers and human liver cancer cells by downregulating key positive regulators like PPARγ and PGC-1α.
* The antioxidant N-acetylcysteine (NAC) can counteract the effects of ATO by helping to restore CAT expression and alleviating liver toxicity, highlighting its potential in treatment and forensic diagnosis.

J Forensic Leg Med

May 2024

- The text discusses a rare case of a woman in her 30s who experienced severe complications, including a cervical hematoma and airway obstruction, following facial liposuction, highlighting the potential risks associated with the procedure.
- Despite liposuction being performed worldwide, this case is unique as it is one of the first reports of fatal complications related to facial liposuction specifically, underscoring the risks involved in cosmetic surgeries.
- After developing symptoms post-surgery, the patient went into cardiopulmonary arrest and ultimately passed away, with an autopsy revealing significant swelling, a hematoma, and a damaged artery that contributed to airway obstruction.

Front Neurol

September 2023

Intracranial vertebral artery dissection (IVAD) is a rare and serious condition that can lead to fatal subarachnoid hemorrhage or ischemic stroke, particularly in cases of unruptured traumatic IVAD.
This case study discusses a patient who suffered a fatal ischemic stroke after being assaulted, with symptoms worsening over 15 days due to unrecognized IVAD leading to multiple brain infarctions.
Pathological examinations revealed a specific tear in the artery's layers, providing insight into the condition's development and highlighting the need for better understanding of ischemic IVAD.