Publications by authors named "Shutai Jiang"
Hemostatic materials play a crucial role in wound healing by promoting blood concentration or releasing procoagulant factors. While hydrophilic hemostatic materials are effective, they may cause excessive blood loss and difficulty removing from the wound. Conversely, hydrophobic hemostatic materials avoid these issues but may hinder blood concentration and the release of procoagulant factors due to their water-repellent nature.
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- Chinese cordyceps, or Dong-Chong-Xia-Cao, is a prized herb in traditional Chinese medicine, known for supporting the immune system and enhancing lung and kidney functions, along with having anti-tumor and anti-diabetic properties.
- Despite its rarity, many of its active chemical components overlap with those found in other resources, leaving numerous compounds still unidentified.
- A new compound called cordythiazole A was discovered in cordyceps, marking the first thiazole alkaloid identified in this herb, showing promising anti-diabetes effects similar to acarbose.
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- Two new compounds, hostaflavanone A and -1-phenylpropane-1,2-diol-2-β-d-glucopyranoside, were discovered along with six known compounds from a flower, with their structures identified using advanced techniques like NMR and mass spectroscopy.
- The study evaluated the inhibitory effects of these compounds on cyclooxygenases (COX-1 and COX-2), finding moderate inhibition, and only one compound displayed noticeable antioxidant activity.
- This research marks the first identification of these two new compounds from the Liliaceae family and also discusses their potential significance in plant classification.
Dihydrochalcomycin (1) and chalcomycin, (2), two known chalcomycins, and chalcomycin E (3), a new compound, were isolated from marine-derived Streptomyces sp. HK-2006-1. Their structures were elucidated by detailed spectroscopic and X-ray crystallographic analysis.
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- Six new macrolides (aldgamycins J-O) with a unique branched sugar unit were discovered from a Streptomyces strain, alongside two known compounds.
- The structures of these compounds were investigated using advanced spectroscopic and X-ray techniques, revealing that branched sugars like aldgarose are uncommon in natural products.
- All isolated compounds were tested for antimicrobial effects, showing that most were effective against the bacteria Staphylococcus aureus and providing insights into their structure-activity relationships.
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- Researchers synthesized two derivatives of bufalin, bufadienolactam (1) and secobufalinamide (2), using ammonium acetate, and confirmed their structures through various spectroscopic methods and X-ray diffraction.
- Both derivatives showed effective inhibition against androgen-dependent prostate cancer cells at low concentrations while demonstrating only weak inhibition on Na(+), K(+)-ATPase, suggesting they could be safer alternatives for treating prostate cancer.