Publications by authors named "Shusuke Yamaoka"
Article Synopsis
- - A new group of inhibitors designed to target the mitotic motor protein CENP-E was developed using a chemical method that combines 1,3-diketones with different hydrazines under gentle conditions.
- - The research successfully explored how the structure of the pyrazole photoswitch affects the activity of these CENP-E inhibitors in lab tests (in vitro) and living cells.
- - This study enhances our understanding of how these inhibitors work and their potential applications in biological systems.
An arylazopyrazole-based covalent inhibitor targeting the mitotic motor protein of centromere-associated protein E (CENP-E) was developed. Using this photoswitchable inhibitor, a photoswitchable CENP-E was chemically constructed in cells, which enabled to local control of mitotic cell division with light illumination.
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