Publications by authors named "Shusuke Toda"
Background And Aim: We previously identified that ever-smoking and severe gastric atrophy in pepsinogen are risk factors for synchronous gastric cancers (SGCs). This study aimed to determine the association of alcohol drinking status or alcohol-related genetic polymorphism with SGCs and also stratify their risk.
Methods: This multi-center prospective cohort study included patients who underwent endoscopic submucosal dissection for the initial early gastric cancers at 22 institutions in Japan.
Article Synopsis
- The study investigates how alcohol consumption may contribute to the development of esophageal squamous cell carcinoma (ESCC) by examining the role of NRF2, a protective factor against cancer, in the esophageal mucosa.
- Researchers analyzed biopsy samples from 20 ESCC patients and 20 patients without ESCC to compare the effects of acetaldehyde and ethanol exposure on mRNA levels of NRF2 target genes and transepithelial electrical resistance (TEER).
- Results indicated that while TEER did not significantly change between groups, mRNA levels of NRF2 target genes decreased more in ESCC patients after alcohol exposure, particularly among those with certain genetic and clinical risk factors, suggesting a disruption in NRF2's protective role related to