Publications by authors named "Shushanik A Sargsyan"
J Biomol Struct Dyn
February 2008
Article Synopsis
- Cisplatin Binding
- : The antitumor drug cisplatin distorts DNA's double helix, initially reducing its melting temperature (Tm), but this destabilization is countered by a decrease in DNA charge density, which can increase Tm, especially at low sodium ion concentrations.
- Influence of pH
- : The impact of cisplatin on DNA stability is also affected by pH levels; at alkaline pH (10.5-10.8), the decrease in Tm is significantly heightened due to changes in base pair protonation and charge density, while at neutral pH, this effect is minimal.
- Interstrand Crosslinking
- : Although cisplatin
