Publications by authors named "Shusaku Matsuda"
Article Synopsis
- Joint contracture is a permanent mobility disorder caused by factors like trauma and aging, primarily due to joint capsule fibrosis, but the exact molecular reasons are still unclear.
- A mouse model study revealed that increased levels of the protein periostin (POSTN) in joint capsules are linked to irreversible contractures, with significant fibrosis observed.
- Treatment with POSTN-neutralizing antibodies showed promise in reducing contracture severity, highlighting POSTN as a potential target for future therapies to address joint contracture.
Background: Spontaneous osteonecrosis (SON) of the lateral femoral condyle of the knee joint is very rare and there have been only a few articles about this condition.
Materials: We reviewed data for 11 patients (7 men, 4 women) with unusual SON of the lateral femoral condyle of the knee. The average age of patients at onset was 61.
One of the major bottlenecks in malaria research has been the difficulty in recombinant protein expression. Here, we report the application of the wheat germ cell-free system for the successful production of malaria proteins. For proof of principle, the Pfs25, PfCSP, and PfAMA1 proteins were chosen.
View Article and Find Full Text PDFThis study aimed to examine the peritoneal penetration and pharmacodynamic exposure of intravenous cefozopran. Cefozopran 1 g was administered to 10 patients before abdominal surgery. Venous blood and peritoneal fluid (PF) samples were obtained at the end of the 0.
View Article and Find Full Text PDFThis study reports the results for 10 patients with recurrent hemarthrosis after knee joint arthroplasty. The average interval between arthroplasty and the first instance of hemarthrosis was at 26 months, and the average number of hemarthroses per patient was 3.8.
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