ChIP-Seq Analysis of AtfA Interactions in Reveals Its Involvement in Aflatoxin Metabolism and Virulence Under Oxidative Stress.

The risk of contamination is expanding with global warming. Targeting the pathogenicity of at its source and diminishing its colonization within the host may be a potential control strategy. Oxidative stress transcription factor AtfA plays a pivotal role in pathogenicity by combating reactive oxygen species (ROS) generated by host immune cells.

Thymol Induces Fenton-Reaction-Dependent Ferroptosis in .

Thymol has efficient bactericidal activity against a variety of pathogenic bacteria, but the bactericidal mechanism against () has rarely been reported. In the current study, we investigated the bactericidal mechanism of thymol against . The Results revealed that 150 μg/mL of thymol had 99.

Ferrous gluconate triggers ferroptosis in Escherichia coli: Implications of lipid peroxidation and DNA damage.

Microbial ferroptosis has been proved to combat drug-resistant pathogens, but whether this pattern can be applied to the prevention and control of Escherichia coli remains to be further explored. In this study, ferrous gluconate (FeGlu) showed remarkable efficacy in killing E. coli MG1655 with a mortality rate exceeding 99.

Ferrous sulphate triggers ferroptosis in Candida albicans and cures vulvovaginal candidiasis in a mouse model.

Candida albicans is the most leading cause of life-threatening fungal invasive infections, especially for vulvovaginal candidiasis (VVC). Resistance and tolerance to common fungicide has risen great demands on alternative strategies for treating C. albicans infections.

An "intelligent -responsive" bactericidal system based on OSA-starch Pickering emulsion.

Pickering emulsion based on OSA-starch was developed in this study as an intelligent delivery system for the application of thymol against foodborne pathogens. Morphology and microstructure characterization showed that the Pickering emulsion was an O/W type emulsion and stayed stable at starch concentration of 200 mg/mL and oil fraction at 30 % with particle size of 10 μm and absolute Zeta potential of -12.5 mV.

Fe protects postharvest pitaya ( from infection by directly binding its genomic DNA.

is a postharvest fungus, causing pitaya fruit decay and limiting pitaya value and shelf life. However, safer and more efficient methods for preventing contamination for pitaya fruit remain to be investigated. In this study, we successfully proved exogenous Fe could inhibit colonization in pitaya fruit and extend pitaya's shelf life after harvest.

Exogenous Iron Induces NADPH Oxidases-Dependent Ferroptosis in the Conidia of .

is saprophytic soil fungus that contaminates seed crops with the carcinogenic secondary metabolite aflatoxin, posing a significant threat to humans and animals. Ferrous sulfate is a common iron supplement that is used to the treatment of iron-deficiency anemia. Here, we identified an unexpected inhibitory role of ferrous sulfate on .

EGCG Alleviates Oxidative Stress and Inhibits Aflatoxin B Biosynthesis via MAPK Signaling Pathway.

Aflatoxin biosynthesis has established a connection with oxidative stress, suggesting a prevention strategy for aflatoxin contamination via reactive oxygen species (ROS) removal. Epigallocatechin gallate (EGCG) is one of the most active and the richest molecules in green tea with well-known antioxidant effects. Here, we found EGCG could inhibit aflatoxin B (AFB) biosynthesis without affecting mycelial growth in , and the arrest occurred before the synthesis of toxin intermediate metabolites.