Several kinds of UiO-66-NH with different aggregation morphologies were prepared to verify that the morphology of the photocatalyst could influence charge transfer. That showing poor aggregation exhibits superior CO photoreduction performance, attributed to the small particle size related to the poor aggregation and to the resulting high efficiency of separation of photogenerated electrons and holes.
View Article and Find Full Text PDFAcyl-CoA: cholesterol acyltransferase (ACAT), a pivotal enzyme in the absorption and metabolism of cholesterol, is primarily responsible for intracellular esterification. ACAT inhibition is expected to diminish plasma lipid levels by impeding intestinal cholesterol absorption, thereby preventing the progression of atherosclerotic lesions. A previous study shows that selective inhibition of ACAT2 significantly mitigated hypercholesterolaemia and atherosclerosis in mouse models.
View Article and Find Full Text PDFAcetyl-coenzyme A carboxylase (ACC) and diacylglycerol acyltransferase 2 (DGAT2) are recognized as potential therapeutic targets for nonalcoholic fatty liver disease (NAFLD). Inhibitors targeting ACC and DGAT2 have exhibited the capacity to reduce hepatic fat in individuals afflicted with NAFLD. However, there are no reports of dual inhibitors targeting ACC and DGAT2 for the treatment of NAFLD.
View Article and Find Full Text PDFdsRNA is a product related impurity produced during the mRNA manufacturing process. The established immuno-based detection methods lack the flexibility and speed required to be applied throughout the manufacturing process. The RP-HPLC method developed outperforms these in terms of precision, broader detection range, LOD and LOQ, as well as in output variance.
View Article and Find Full Text PDFCholesteryl ester transfer protein (CETP) is a promising therapeutic target for cardiovascular diseases. It effectively lowers the low-density lipoprotein cholesterol levels and increases the high-density lipoprotein cholesterol levels in the human plasma. This study identified novel and highly potent CETP inhibitors using virtual screening techniques.
View Article and Find Full Text PDF'Zaosu' pear fruit is prone to yellowing of the surface and softening of the flesh after harvest. This work was performed to assess the influences of L-glutamate treatment on the quality of 'Zaosu' pears and elucidate the underlying mechanisms involved. Results demonstrated that L-glutamate immersion reduced ethylene release, respiratory intensity, weight loss, brightness (L*), redness (a*), yellowness (b*), and total coloration difference (ΔE); enhanced ascorbic acid, soluble solids, and soluble sugar contents; maintained chlorophyll content and flesh firmness of pears.
View Article and Find Full Text PDFFree amino acids (FAAs) positively determine the tea quality, notably theanine (Thea), endowing umami taste of tea infusion, which is the profoundly prevalent research in albino tea genetic resources. Therefore, 339 tea accessions were collected to study FAAs level for deciphering its variation and accumulation mechanism. Interestingly, alanine (Ala) and Thea which had the highest diversity index () value among three varieties of (L.
View Article and Find Full Text PDFOur prophase studies have manifested that the sweet triterpenoid glycoside from the leaves of (CPST) effectively improved the disorders of glucolipid metabolism and in patients. The current purpose was to further detect its mechanisms involved. The results demonstrated that CPST could ameliorate high-fat diet (HFD)-induced insulin resistance (IR), which was linked to reducing HFD-induced mice's body weight, serum glucose (GLUO), triglyceride (TG), total cholesterol (T-CHO) and low-density lipoprotein cholesterol (LDL-C), lowering the area under the oral glucose tolerance curve and insulin tolerance, elevating the percentage of brown adipose, high-density lipoprotein cholesterol (HDL-C), reducing fat droplets of adipocytes in interscapular brown adipose tissue (iBAT) and cross-sectional area of adipocytes.
View Article and Find Full Text PDF(Batalin) Iljinskaja () is a single species of in Juglandaceae. It is a unique rare medicinal plant resource in China that is mainly distributed in the south of China. The leaves of , as a new food ingredient, are processed into tea products in daily life.
View Article and Find Full Text PDFThe study of aggregate formation and its controllable effect on luminescence behavior has a far-reaching influence in establishing a universal aggregation photophysical mechanism. In this paper, we obtained clusters with different extents of aggregation by heat-induced or light-triggered aggregation of a new polyurethane derivative (). The controllable regulation of multicolor fluorescence of a single (nondoped) polymeric material is realized.
View Article and Find Full Text PDFIn this study, a new cobalt-based metal-organic framework (), [Co(OH)(PBA)(AIP)]·3DMA·0.75HO (4-(pyridin-4-yl) benzoic acid (HPBA), 5-aminoisophthalic acid (HAIP) and ,-dimethylacetamide (DMA)), was fabricated using a solvothermal method. has 3D network architecture with 1D nanopore channels.
View Article and Find Full Text PDFCurrently, the preparation of high-performance electrode materials is urgently needed for supercapacitors. As a new kind of organic porous material, covalent organic frameworks (COFs) with an ordered pore structure, a high specific surface area and designability, have shown great potential application value as electrode materials for supercapacitors. However, their potential application in supercapacitors is limited by the poor conductivity of COFs.
View Article and Find Full Text PDFAs a rising class of crystallographic organic polymers, covalent-organic frameworks (COFs) have high specific surface areas, ordered pore structures, and designability, which exhibit broad application prospects in the energy storage sector. However, their low electrical conductivity hinders their potential use in supercapacitors. To improve the electrical conductivity, we introduced carboxylated multi-walled carbon nanotubes to obtain a series of carbon nanotube@COF composites by a facile one-pot method, in which 2D TFA-COFs are grown on the surface of carboxylated multi-walled carbon nanotubes.
View Article and Find Full Text PDFThe evolutionarily conserved () microRNAs (miRNAs) are well-known activators of proliferative quiescence and terminal differentiation. However, in the murine auditory organ, overexpression delays the differentiation of mechano-sensory hair cells (HCs). To address whether the role of in auditory-sensory differentiation is conserved among vertebrates, we manipulated levels within the chicken auditory organ: the basilar papilla.
View Article and Find Full Text PDFReductive soil disinfestation (RSD) is an effective agricultural practice to eliminate soil-borne pathogens that heavily relies on the organic substrate used. However, the influences of combined application of organic residues on disinfestation efficiency, soil microbiomes, and their associated functional characteristics are still not well-characterized. In this work, four treatments, i.
View Article and Find Full Text PDFPorous cationic covalent triazine-based frameworks (CTFs) with imidazolium salts as tectons were prepared via ionothermal synthesis. The high-PF -content CTF shows the CO adsorption of 44.7 cm g and I capture capacity of 312 wt %.
View Article and Find Full Text PDFThe mammalian auditory sensory epithelium has one of the most stereotyped cellular patterns known in vertebrates. Mechano-sensory hair cells are arranged in precise rows, with one row of inner and three rows of outer hair cells spanning the length of the spiral-shaped sensory epithelium. Aiding such precise cellular patterning, differentiation of the auditory sensory epithelium is precisely timed and follows a steep longitudinal gradient.
View Article and Find Full Text PDFIn this work, a multifunctional microporous metal-organic framework (MOF), [Cd(ABTC)(HO)(DMA)]·4DMA (JLNU-4; JLNU = Jilin Normal University; HABTC = 3,3',5,5'-azobenzenetetracarboxylic acid), has been synthesized based on the ligand HABTC under solvothermal conditions. JLNU-4 shows excellent uptake of iodine both in solution and in the vapor phase, owing to the existence of a microporous structure in JLNU-4. The adsorption kinetics during the process of iodine adsorption were analyzed a series of qualitative and quantitative analyses, such as the Langmuir and Freündlich adsorption isotherms.
View Article and Find Full Text PDFTwo novel isostructural polyoxometalate (POM)-based metal-organic frameworks (MOFs) with diamond topology, NENU-506 and NENU-507, were hydrothermally synthesized. They not only combine the advantages of both POMs and MOFs, but also show excellent chemical and thermal stability. Notably, NENU-507 exhibited a high reversible capacity of 640 mA h g after 100 cycles when applied as an anode material in lithium-ion batteries.
View Article and Find Full Text PDFParkinson's disease (PD) is a chronic progressive neurodegenerative disorder. Recent studies have implicated a role for peroxisome proliferator-activated receptor γ coactivator protein-1α (PGC-1α) in PD and in animal or cellular models of PD. The role of PGC-1α in the function and survival of substantia nigra pars compacta (SNpc) dopamine neurons is not clear.
View Article and Find Full Text PDFTwo novel polyoxometalate (POM)-based coordination polymers, namely, [Co(bpz)(Hbpz)][Co(SO4 )0.5 (H2 O)2 (bpz)]4 [PMo(VI) 8 Mo(V) 4 V(IV) 4 O42 ]⋅13 H2 O (NENU-530) and [Ni2 (bpz)(Hbpz)3 (H2 O)2 ][PMo(VI) 8 Mo(V) 4 V(IV) 4 O44 ]⋅8 H2 O (NENU-531) (H2 bpz=3,3',5,5'-tetramethyl-4,4'-bipyrazole), were isolated by hydrothermal methods, which represented 3D networks constructed by POM units, the protonated ligand and sulfate group. In contrast with most POM-based coordination polymers, these two compounds exhibit exceptional excellent chemical and thermal stability.
View Article and Find Full Text PDFA series of isoreticular metal-organic frameworks (MOFs; NENU-511-NENU-514), which all have high surface areas and strong adsorption capacities, have been successfully constructed by using mixed ligands. NENU-513 has the highest benzene capacity of 1687 mg g(-1) at 298 K, which ranks as the top MOF material among those reported up to now. This NENU series has been used for adsorptive desulfurization because of its permanent porosity.
View Article and Find Full Text PDFA stable porous carbazole-based luminescent metal-organic framework, NENU-522, was successfully constructed. It is extremely stable in air and acidic/basic aqueous solutions, which provides the strategy for luminescent material encapsulation of Ln(3+) ions with tunable luminescence for application in light emission. More importantly, Ln(3+)@NENU-522 can emit white light by encapsulating different molar ratios of Eu(3+) and Tb(3+) ions.
View Article and Find Full Text PDFIn this work, five novel 2D isostructural Cd(II)-lanthanide(III) heterometallic-organic frameworks [CdCl(L)Eu(x)Tb(y)(H2O)(DMA)](NO3)·3DMA (IFMC-36-Eu(x)Tb(y): x = 1, y = 0, IFMC-36-Eu; x = 0.6, y = 0.4, IFMC-36-Eu(0.
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