Publications by authors named "Shuran Yu"
Article Synopsis
- Some lactic acid bacteria (LAB) have health benefits essential for the conservation of endangered animals, specifically giant pandas, but their diversity in pandas' gut microbiota is largely unexplored.
- The researchers created a culture pipeline to isolate and study LAB strains from giant pandas using various growth conditions, resulting in a significant collection of bacterial strains.
- The study revealed that the cultured bacteria were more diverse than those found in culture-independent methods, laying groundwork for future research on LAB's potential health benefits and probiotic applications in conservation efforts.
Article Synopsis
- The study investigates the protective effects of probiotics derived from giant pandas against colitis induced by dextran sodium sulfate (DSS) in mice.
- B14, one of the probiotics tested, showed a stronger ability to prevent colitis symptoms compared to another strain (B13), by reducing inflammatory markers and improving intestinal health.
- The research indicates that B14 enhances the intestinal barrier and regulates immune responses, leading to a better balance of beneficial gut bacteria, ultimately preventing colitis in the mice.
Purpose: The purpose of this study was to establish a protein binding model of unbound valproic acid (VPA) based on Chinese pediatric patients with epilepsy and provide a reference for clinical medication.
Methods: A total of 313 patients were included and both their total and unbound VPA concentrations (375 pairs of concentrations) were measured. NONMEM software was used for population pharmacokinetic modeling.
Aim: In order to monitor the free concentration of VPA in plasma, a simple and rapid method needs to be developed.
Methods: The free fraction of VPA in plasma was obtained by centrifugal ultrafiltration (CF-UF) devices. Cyclohexanecarboxylic acid was used as internal standard.
Long noncoding RNA H19 promotes chemotherapy resistance in choriocarcinoma cells.
J Cell Biochem
September 2019
Choriocarcinoma (CC) is a trophoblast tumor prone to early distant organ metastases. At present, the main treatment for CC is chemotherapy, but chemotherapy resistance readily occurs and leads to treatment failure. H19 is a long noncoding RNA, and its abnormal expression has been found in various tumors, including CC.
View Article and Find Full Text PDFChoriocarcinoma is sensitive to chemotherapy. However, drug resistance has become one of the major problems in recent years. Previous studies have shown that many tumors contained a small fraction of cells that exhibited enhanced tumor initiating potential and stem cell-like properties.
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