[Identification of potential hazards and analysis of critical control points in cultured meat production].

The development of food technologies at the present stage is aimed at expanding the range of food raw materials, including alternative food sources. One of such sources is meat derived from in vitro stem cells or cultured meat. The stages of in vitro meat production could be divided into four blocks: preparation of raw materials, cultivation of cells in a nutrient medium, forming the final product and preparing meat for sale to the consumer.

[Comparative characteristics of the amino acid composition of protein from traditional sources and entomoprotein: calculated data].

The growth of the world population leads to an increase in demand for food consumption. Along with the projected reduction in demand for meat products, a search is underway for a new type of food ("novel food"), one of the promising options for which are insects. In 2023 the European Commission has registered flour made from house cricket (Acheta domesticus) as a "novel food" for human consumption.

[Health risk assessment associated with priority potentially hazardous chemical compounds detected in canned meat and meat-and-vegetable food for infants].

Assessment of public health safety associated with chemical contaminants consumed with food is an important component for solving the tasks of ensuring the sanitary and epidemiological well-being of the population. For these purposes, it is necessary to establish priority potentially dangerous compounds among the identified undeclared and unintended chemical contaminants for further consumers risk assessment. In conditions of unacceptable levels of health risk, it is necessary to decide whether it is advisable to develop new or change existing hygiene standards for these substances.

[The modification of methodological approaches for potential hazard identification of inadvertent chemicals in food].

The existing methodological approaches for hazard identification and selection of priority hazard contaminants in foodstuff for further health risk assessment and legislation (in case of need) do not represent the reasons of inclusion inadvertent chemical substances in a number of priority for health risk assessment. The absence both of complex assessment and potential hazard categories of contaminants do not allow to assess the urgency of health risk assessment. Thus, it's advisable to expand the existing methodological approaches with the criteria of selection of hazard inadvertent chemical substances in food.

[New potential of MTHFR gene variations application as an individual sensitivity marker in evaluation of occupational risk of arterial hypertension under exposure to nose].

The article deals with results of assessing risk of occupationally related hypertension among workers of sylvinitedressing works, with individual sensitivity consideration. Epidemiologic study proved correlation between occupational exposure to noise over 83 dB and hypertension and its predictors - increased activity of serum lipoprotein and homocystein. The studies determined an indicator of the workers' increased sensitivity to arterial hypertension development and to changes in parameters of disordered vascular tone regulation (increased activity of serum lipoprotein and homocystein) under exposure to noise - CT genotype of MTHFR gene.

Evaluation of health risk for workers engaged into processing of titanium-containing and rare-earth materials.

The authors defined occupational risk level and relations of health disorders in workers engaged into processing of titanium-containing and rare-elements materials with forecasting risk changes in accordance with length of service and its realization evaluation. Work conditions are characterized by exposure to chemicals (sulphur dioxide, nitrogen oxide, chlorine and hydrochloride, vanadium compounds), noise, general vibration, heating, work hardiness - and are evaluated as hazardous, jeopardy degree 3 and 4. Results of a priori assessment of occupational risk define it as high.

[Occupational risk of cardiovascular diseases in workers engaged into underground mining].

The article presents results of evaluation of a priori and a posteriori occupational risks for workers engaged into underground mining. Evidence is that work conditions of major occupational groups of workers engaged into underground mining, according to workplace certification, correspond to 3 class 3 jeopardy degree. A priori risk of diseases development corresponds to high (unbearable).

[METHODS AND TECHNOLOGIES OF HEALTH RISK ANALYSIS IN THE SYSTEM OF THE STATE MANAGEMENT UNDER ASSURANCE OF THE SANITATION AND EPIDEMIOLOGICAL WELFARE OF POPULATION].

The methodology of the analysis of health risk at the present stage of development of Russian society is in-demand at all levels of government management. In conjunction with the methods of mathematical modeling, spatial-temporal analysis and economic tools the risk assessment in the analysis of the situation makes it possible to determine the level of safety of the population, workers and consumers, to select prior resources, and threat factors as a point for exertion efforts. At the planning stage risk assessment is a basis for the establishment of most effective measures for the minimization of hazard and dangers.

[OCCUPATIONAL HEALTH RISK ASSESSMENT AND MANAGEMENT IN WORKERS IN IMPROVEMENT OF NATIONAL POLICY IN OCCUPATIONAL HYGIENE AND SAFETY].

In accordance with the international documents in the field of occupational safety and hygiene, the assessment and minimization of occupational risks is a key instrument for the health maintenance of workers. One of the main ways to achieve it is the minimization of occupational risks. Correspondingly, the instrument for the implementation of this method is the methodology of analysis of occupational risks.

[Methodological approaches to the substantiation of a harmonized mean year maximum permissible nickel concentration in ambient air].

In the article there are presented the results of the substantiation of a harmonized mean year maximum permissible nickel concentrations (MPNC) in ambient air according to the results of epidemiological studies and mathematical modeling of the evolution of risk Data of the analysis of hygienic standards of the nickel content in the air used both in Russia and abroad, as well as the results of the own research allow us to recommend as a harmonized mean year MPNC-0.00005 mg/m3, and as critical effects--disorders of the respiratory organs.

[Experience of justification of hygienic standards of food safety with the use of criteria for the risk population health].

In the article there is presented the experience of justification of hygienic standards of food safety with the use of criteria for the risk for population health. Health risk assessment under the impact of tetracyclines with food showed that the content of residual amounts of these antibiotics at the level of 10 mg/kg (permissible residual tetracycline accepted in Customs Union Member Countries (CUMC) will not increase the risk to public health, including the most sensitive groups of the population. The assessment ofthe health risk associated with the receipt of ractopamine with food, showed that eating foods containing ractopamine at ADI level (0-1 mg/kg body weight), and even at the limit of quantification levels in meat products, is inadmissible because of unacceptable risk of functional disorders and diseases of the cardiovascular system.

[Development of lipids and carbohydrates metabolism disorders caused by drinkable water with high content of chlorine organic compounds].

Evaluation of effects caused by environmental peroral exposure to chlorine organic compounds revealed that individuals with AG variation of HTR2A gene are a community with increased sensitivity to chloroform and a risk group for lipid and carbohydrates metabolism disorders. Individual risk of endocrine disorders (ICD: E67.8 excessive nutrition and E66.

[Forming a community at risk for circulatory system diseases among workers engaged into underground mining].

Forming a community at risk for circulatory system diseases will increase efficiency of medical and prophylactic measures on managing risk of arterial hypertension. Epidemiologic analysis helped to reveal reliable connection between arterial hypertension predictors and work conditions of mining machine operators and supported actualization of high occupational risk suggested in a priori evaluation. Mathematic modelling helped to forecast increase in the disease probability: with noise level of 94 dB after 10 years of work, 17.

[Prospects of occupational risk evaluation via modelling methods].

The article represents methodic approaches that enable quantitative evaluation of worker's health risk, forecast of changes in health state. Models application proved that integral risk of health disorders in workers exposed to occupational factors becomes unacceptable by the age of 45 years, without exposure to the factors - by 54 years. At work under existing levels of exposure to occupational factors, cardiovascular risk increases with length of service, and by 5 years of service, number of additional occupational cases in a studied group of workers approaches 11 per year.

[Improvement of legislation basis for occupational risk analysis in occupational hygiene and work safety].

One among priority trendsin health care in Russian Federation and abroad is minimization of occupational risks. The authors present evaluation of legislation basis for occupational risk analysis. The most promising trend in improvement of national legislation is its development on basis of internationally accepted documents, that-provides legislation basis for analysis of workers' health risk.

[Identification of social risk factors for health of preschool children residing in areas with high anthropogenic load].

In the article there is substantiated the need to include social factors (particularly lifestyle factors) in the risk assessment procedure of the health of children residing in conditions of anthropogenic impact on the environment. The purpose and algorithm for identification of social risk factors are disclosed. There are reported results of testing of author's approaches as exemplified of the Perm region (sample size--642 people).

[About the human health safety estimation of ractopamine intake together with the food].

The analysis of scientific data including American and European scientific communities concerning use of ractopamine as a growth factor in food animal production and the argumentation of the maximum permitted levels of ractopamine and levels of ractopamine in meat and byproducts (offal) is carried out. The position of the Russian side stated at the Codex Alimentarius commission 35th session that acceptable ractopamine daily intake is insufficiently validated and cannot be used for the determination of maximum permitted levels of ractopamine in meat and byproducts (offal) is confirmed. It is represented that residual ractopamine intake together with food on the levels which are recommended by the Codex Alimentarius commission and by taking into account the levels of animal products consumption in Russian Federation will lead to unacceptable human health risk level that will promote increasing heart diseases and life expectancy reduction.

[Hygienic features of work conditions and their influence on health of workers engaged in ferrovanadium production].

The authors present complex hygienic characteristics of work conditions for workers engaged into metallurgic process of ferrovanadium production. Chemical factors were shown as having complex influences. Occupational risk for the workers' health was estimated.

[Concomitant influence of occupational and social risk factors on health of workers engaged into powder metallurgy].

Results of health risk evaluation in workers engaged into powder metallurgy, using complex of hygienic, medical, epidemiologic and sociologic studies, enable to define priority occupational and social risk factors, to assess degree of their influence on the workers' health and to identify occupationally induced diseases.

[Qualitative assessment of a noncarcinogenic risk to human health].

The existing methodic approaches to analyzing a noncarcinogenic risk fail to fully solve the tasks set within the basic lines of the activities of the Russian Agency for Consumer Surveillance since there are limited capacities of the quantitative assessment of a noncarcinogenic risk to human health. An algorithm is proposed for basing the indicators assessing a noncarcinogenic risk to human health, which assumes to determine exposure or an exposure marker for a cohort to be examined, to define a response to human health exposure, to construct mathematical "exposure (an exposure marker)-response" models, to determine the ineffective levels exposure for each type of a response, to make the piecewise-linear approximation of a model, and to calculate a slope factor for each linearized interval of an exposure-response model. Application of the proposed methodic approaches makes it possible, provided that the estimation of the cost of risk units, to assess the economic loss risk associated with the pollution of environmental objects, including a preventable risk, and to calculate the indicators of the effectiveness and efficiency of the activities of the bodies and organizations of the Russian Agency for Consumer Surveillance in reducing the risk to the population's health.

[Effect of monohydric aliphatic alcohols on children's health].

To form the evidence base of the "environmental determination" of disease is a topical line in human ecology and environmental hygiene. The widespread use of monohydric aliphatic alcohols in industry has determined the necessity of making an in-depth study of their toxic effects on man, by taking into account their actual concentrations forming in the blood. The results of the studies have led to the conclusion that the real risk of toxic exposure of an organism to monohydric alcohols forms when the blood concentrations of butyl alcohols, propyl alcohols, and methyl alcohol are over 0.