Withering and Fermentation Affect the Transformation and Accumulation of Key Metabolites in Rougui () for the Formation of Special Taste Characteristics.

During the production of Wuyi rock tea, withering and fermentation play a crucial role in the primary processing of the tea, greatly influencing the development of its distinct taste characteristics. In this study, Rougui () was selected as the research object to investigate the effects of withering and fermentation on metabolites and taste characteristics in tea leaves. The findings revealed that a total of 1249 metabolites were detected in Rougui leaves at various processing stages, of which only 40 key metabolites were significantly altered.

A scalable and durable polydimethylsiloxane-coated nanoporous polyethylene textile for daytime radiative cooling.

Radiative cooling technology with zero-energy consumption and zero-carbon emission has drawn enormous attention. However, the high-cost manufacture, limited scalability, and narrow application scopes remain major impediments to radiative cooling commercialization. Here, we present a bilayer PDMS/nanoPE fabricated by an automatic film applicator for high-performance passive daytime radiative cooling.

Characterizing metabolomic and transcriptomic changes, and investigating the therapeutic mechanism of linn. In the treatment of kidney-yang deficiency syndrome in rats.

Kidney-yang deficiency syndrome (KYDS) is characterized by a metabolic disorder stemming from neuroendocrine dysregulation, often associated with hepatic dysfunction. In traditional Chinese medicine, Linn. (BGZ) is commonly utilized for treating KYDS.

Disparities in Access to, Use of, and Quality of Rehabilitation After Stroke in the United States: A Scoping Review.

Objectives: To summarize current reports in the literature on disparities in rehabilitation after stroke; identify gaps in our understanding of rehabilitation disparities; and make recommendations for future research.

Data Sources: A health sciences librarian developed a search string based on an a priori protocol and searched Medline (Ovid) Embase (Elsevier), and the Cumulative Index to Nursing and Allied Health Literature (CINAHL and EBSCO).

Study Selection: A 2-step screening process of titles and abstracts followed by full-text review was conducted.

Effective Prediction of Drug Transport in a Partially Liquefied Vitreous Humor: Physics-informed Neural Network Modeling for Irregular Liquefaction Geometry.

As the medium for intravitreal drug delivery, the vitreous body can significantly influence drug delivery because of various possible liquefaction geometries. This work innovatively proposes a varying-porosity approach that is capable of solving the pressure and velocity fields in the heterogeneous vitreous with randomly-shaped liquefaction geometry, validated with a finite difference model. Doing so enables patient-specific treatment for intravitreal drug delivery and can significantly improve treatment efficacy.

Universal Protection of Allogeneic T-Cell Therapies from Natural Killer Cells via CD300a Agonism.

Immunogenicity limits the persistence of off-the-shelf, allogeneic cell therapies and transplants. While ablation of human leukocyte antigen (HLA) removes most T cell and humoral alloreactivity, no solution has enabled universal protection against the resulting natural killer (NK) cell response. Here, we engineered Trans Antigen Signaling Receptors (TASR) as a new class of NK inhibitory ligands and discovered CD300a, a previously inaccessible receptor, as a functional target.

Analysis of rhizosphere soil microbial diversity and its functions between Dahongpao mother tree and cutting Dahongpao.

Dahongpao mother tree ( (L.) O. Ktze) is a representative of Wuyi rock tea.

A computational mechanistic study on the formation of aryl sulfonyl fluorides via Bi(III) redox-neutral catalysis and further rational design.

Sulfonyl fluorides hold significant importance as highly valued intermediates in chemical biology due to their optimal balance of biocompatibility with both aqueous stability and protein reactivity. The Cornella group introduced a one-pot strategy for synthesizing aryl sulfonyl fluorides via Bi(III) redox-neutral catalysis, which facilitates the transmetallation and direct insertion of SO into the BiC(sp) bond giving the aryl sulfonyl fluorides. We report herein a comprehensive computational investigation of the redox-neutral Bi(III) catalytic mechanism, disclose the critical role of the Bi(III) catalyst and base (i.

The Ability of Different Tea Tree Germplasm Resources in South China to Aggregate Rhizosphere Soil Characteristic Fungi Affects Tea Quality.

It is generally recognized that the quality differences in plant germplasm resources are genetically determined, and that only a good "pedigree" can have good quality. Ecological memory of plants and rhizosphere soil fungi provides a new perspective to understand this phenomenon. Here, we selected 45 tea tree germplasm resources and analyzed the rhizosphere soil fungi, nutrient content and tea quality.

Multistrategy Engineering of an Inulosucrase to Enhance the Activity and Thermostability for Efficient Production of Microbial Inulin.

Inulin has found commercial applications in the pharmaceutical, nutraceutical, and food industries due to its beneficial health effects. The enzymatic biosynthesis of microbial inulin has garnered increasing attention. In this study, molecular modification was applied to UMB7800 inulosucrase, an enzyme that specifically produces high-molecular weight inulin, to enhance its catalytic activity and thermostability.

Targeting RBM39 through indisulam induced mis-splicing of mRNA to exert anti-cancer effects in T-cell acute lymphoblastic leukemia.

Background: Despite the use of targeted therapeutic approaches, T-cell acute lymphoblastic leukemia (T-ALL) is still associated with a high incidence of complications and a poor prognosis. Indisulam (also known as E7070), a newly identified molecular glue compound, has demonstrated increased therapeutic efficacy in several types of cancer through the rapid degradation of RBM39. This study aimed to evaluate the therapeutic potential of indisulam in T-ALL, elucidate its underlying mechanisms and explore the role of the RBM39 gene.

Tracking and managing the water-food-environment-ecosystem (WFEE) nexus in groundwater irrigation districts using system dynamics modelling.

Groundwater irrigation districts, which play a crucial role in the Earth's critical zone, are confronted with numerous challenges, including water scarcity, pollution, and ecological degradation. These issues come from multiple systems and are linked to a groundwater-dominated water-food-environment-ecosystem nexus problem related to agricultural activities (WFEE). There is a pressing need for the scientific characterization and evaluation of the WFEE nexus in groundwater irrigation districts to assure high-quality, sustainable development.

Dual-Task Effect on Center of Pressure Oscillations and Prefrontal Cortex Activation Between Young and Older Adults.

: This study aimed to investigate the dual-task effect on conventional center of pressure (CoP) outcomes, CoP oscillations, and prefrontal cortex (PFC) activation between young and older adults. : Fourteen healthy older adults (age: 66.25 ± 3.

Finite element analysis of a three-dimensional cervical spine model with muscles based on CT scan data.

Background: The incidence of cervical spondylosis is increasing, gradually affecting people's normal lives. Establishing a finite element model of the cervical spine is one of the methods for studying cervical spondylosis. MRI (Magnetic Resonance Imaging) still has certain difficulties in transitioning from human imaging to establishing muscle models suitable for finite element analysis.

The Scar-Hidden Surgery on Gynecomastia: Experiences from a Single-Institutional Large Case Series.

Background: To summarize the experiences on the mastoscopic subcutaneous mastectomy for gynecomastia by "nine-step method" based on the "5S" goal and standardize this operation.

Patients And Methods: Between January 1, 2002, and October 31, 2021, a total of 2035 breasts of 1082 male patients with gynecomastia, of which 129 patients with one side, were underwent mastoscopic subcutaneous mastectomy. The follow-up endpoint was 3 months after surgery.

Long-neglected contribution of nitrification to NO emissions in the Yellow River.

Rivers play a significant role in the global nitrous oxide (NO) budget. However, the microbial sources and sinks of NO in river systems are not well understood or quantified, resulting in the prolonged neglect of nitrification. This study investigated the isotopic signatures of NO, thereby quantifying the microbial source of NO production and the degree of NO reduction in the Yellow River.

Triple semicircular canal occlusion with endolymphatic sac decompression for intractable Meniere's disease.

Background: Meniere's disease (MD) is characterized by idiopathic endolymphatic hydrops (ELH). Frequent vertigo attacks is the most disabling symptom of MD.

Objective: This study evaluated the efficacy of triple semicircular canal occlusion combined with endolymphatic sac decompression in the treatment of frequent vertigo in patients with MD.

Trust over the transition to parenthood: Links to attachment, perception of partner's caregiving, and parenting.

We examined couples' dyadic trust profiles over the transition to parenthood and their associations with couples' attachment representations, perceptions of partner's caregiving, and parenting quality. We followed 125 couples from pregnancy to 24 months postpartum and applied the latent profile analysis (LPA) to examine whether distinct dyadic patterns of trust would emerge among couples. We then examined couples' attachment representations and perceptions of partner's caregiving as factors that might explain their trust profiles.

Peroxidase-like activity and mechanism of gold nanoparticle-modified TiC MXenes for the construction of HO and ampicillin colorimetric sensors.

Transition metal carbides modified by Au nanoparticles (Au/TiC) were synthesized and developed as a colorimetric sensor for the determination of HO and ampicillin. The surface electrical properties of TiC were changed, and Au nanoparticles (AuNPs) and gold growth solution were synthesized simultaneously. Au/TiC was obtained by seed growth method with AuNPs modified on the surface of transition metal carbides, nitrides or carbon-nitrides (TiC MXenes).

The Impact of Sleep Quality on Cognitive Function in Patients with Chronic Subjective Tinnitus.

Background: The aim of this study was to explore the impact of sleep quality on cognitive function in patients with chronic subjective tinnitus.

Methods: The Pittsburgh Sleep Quality Index (PSQI) and the Montreal Cognitive Assessment Scale (MoCA) were used to assess sleep quality and cognitive function in patients with chronic subjective tinnitus, sleep disorder patients (SD), and normal controls (NC). The tinnitus evaluation questionnaire (TEQ) and tinnitus loudness were used to assess the severity in patients with chronic subjective tinnitus.