Deciphering the molecular nexus between Omicron infection and acute kidney injury: a bioinformatics approach.

Background: The ongoing global health crisis of COVID-19, and particularly the challenges posed by recurrent infections of the Omicron variant, have significantly strained healthcare systems worldwide. There is a growing body of evidence indicating an increased susceptibility to Omicron infection in patients suffering from Acute Kidney Injury (AKI). However, the intricate molecular interplay between AKI and Omicron variant of COVID-19 remains largely enigmatic.

Integrative analysis of potential diagnostic markers and therapeutic targets for glomerulus-associated diabetic nephropathy based on cellular senescence.

Introduction: Diabetic nephropathy (DN), distinguished by detrimental changes in the renal glomeruli, is regarded as the leading cause of death from end-stage renal disease among diabetics. Cellular senescence plays a paramount role, profoundly affecting the onset and progression of chronic kidney disease (CKD) and acute kidney injuries. This study was designed to delve deeply into the pathological mechanisms between glomerulus-associated DN and cellular senescence.

Histone methyltransferase SUV39H2 regulates apoptosis and chemosensitivity in prostate cancer through AKT/FOXO signaling pathway.

Prostate cancer (PCa) is one of the most common malignant tumors that exhibit both chemoresistance and recurrence. SUV39H2 is highly expressed in many types of human tumors, but its role in the development and progression of PCa has never been clarified. The aim of this study is to elucidate the role of SUV39H2 in the development and progression of PCa, its association with the AKT/FOXO signaling pathway, and its potential implications for PCa diagnosis and treatment.

HBeAg-negative Patients with Chronic Hepatitis B Virus Infection and Normal Alanine Aminotransferase: Wait or Treat?

Alanine aminotransferase (ALT) is a common clinical indicator of liver inflammation. The current Chinese guidelines for the management of chronic hepatitis B (CHB) recommend antiviral treatment for patients with detectable hepatitis B virus (HBV) DNA and persistent ALT levels (ALTs) exceeding the upper limit of normal. However, it has been recently reported that patients with chronic HBV infection, especially HBeAg-negative patients with persistently normal ALTs, may have liver biopsy findings of significant inflammation and fibrosis.

One-pot synthesis of porous N-doped hydrochar for atrazine removal from aqueous phase: Co-activation and adsorption mechanisms.

KOH-activated N-doped hydrochar (KHCN) was synthesized via co-activation method to eliminate atrazine (AT) in water efficiently. Compared to primitive HC, KHCN had advantages of splendid specific surface area (1205.82 m/g) and developed microsphere structures on the surface.

Periventricular white matter hyperintensities are associated with gait and balance in patients with minor stroke.

Objective: Cerebral small vessel disease (CSVD) is associated with gait and balance deficits in older adults. However, the effect of CSVD-related brain injury on post-stroke mobility is unknown. This study aimed to investigate the association of CSVD with gait and balance impairment after a minor stroke.

Association of Cerebral Small Vessel Disease With Gait and Balance Disorders.

Cerebral small vessel disease (CSVD) is a common cerebrovascular disease and an important cause of gait and balance disorders. Gait and balance disorders can further lead to an increased risk of falls and a decreased quality of life. CSVD can damage gait and balance function by affecting cognitive function or directly disrupting motor pathways, and different CSVD imaging features have different characteristics of gait and balance impairment.

Ball milling potassium ferrate activated biochar for efficient chromium and tetracycline decontamination: Insights into activation and adsorption mechanisms.

Herein, novel Fe-biochar composites (MBC and MBC) were synthesized through KFeO co-pyrolysis and ball milling, and were used to eliminate Cr(VI)/TC from water. Characterization results revealed that higher temperature promoted formation of zero-valent iron and FeC on MBC through carbothermal reduction between KFeO and biochar. The higher specific surface area and smaller particle size of MBC stemmed from the corrosive functions of K and the ball milling process.

Effective lead passivation in soil by bone char/CMC-stabilized FeS composite loading with phosphate-solubilizing bacteria.

Bioremediation by phosphate-solubilizing bacteria (PSB) has attracted extensive attentions due to its economical and eco-friendly properties for lead (Pb) passivation in soil. Herein, bone char (BC) supported biochemical composite (CFB-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC) was designed and applied to Pb passivation. The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.

Bimodal regulation of the PRC2 complex by USP7 underlies tumorigenesis.

Although overexpression of EZH2, a catalytic subunit of the polycomb repressive complex 2 (PRC2), is an eminent feature of various cancers, the regulation of its abundance and function remains insufficiently understood. We report here that the PRC2 complex is physically associated with ubiquitin-specific protease USP7 in cancer cells where USP7 acts to deubiquitinate and stabilize EZH2. Interestingly, we found that USP7-catalyzed H2BK120ub1 deubiquitination is a prerequisite for chromatin loading of PRC2 thus H3K27 trimethylation, and this process is not affected by H2AK119 ubiquitination catalyzed by PRC1.

Microwave-assisted one pot synthesis of β-cyclodextrin modified biochar for concurrent removal of Pb(II) and bisphenol a in water.

Herein, β-cyclodextrin (β-CD) functionalized rice husk-derived biochar (BC) was conveniently and fast synthesized via microwave (MW)-assisted one pot process, and employed for simultaneous elimination of bisphenol A (BPA) and plumbum (Pb). Profiting by microwave irradiation, the surface modification was implemented in 15 min and the prepared BC-β-CD presented an excellent adsorption performance with a heterogeneous adsorption capacity of 209.20 mg/g for BPA and a theoretical monolayer uptake of 240.