IL-1β stimulates ADAMTS9 expression and contributes to preterm prelabor rupture of membranes.

Background: Preterm prelabor rupture of membranes (pPROM) is a leading cause of neonatal morbidity and mortality. While intra-amniotic infection is a well-established driver of pPROM, the role of sterile intra-amniotic inflammation remains unclear. Recent evidence suggests that interleukin-1 beta (IL-1β) promotes extracellular matrix (ECM) remodeling via downstream effectors, a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motif 9 (ADAMTS9), while protein O-fucosyltransferase 2 (POFUT2) facilitates its O-fucosylation and secretion, amplifying ECM degradation.

The rising proportion of Plasmodium ovale spp. in imported malaria in Anhui Province, China: A retrospective propensity score-matched case-control study.

No autochthonous malaria cases have been reported in Anhui Province, China, since 2014. However, imported malaria remains a significant public health concern. Moreover, the proportion of reported imported malaria cases attributed to Plasmodium ovale spp.

RIPK1 is required for ZBP1-driven necroptosis in human cells.

Necroptosis initiated by the host sensor Z-NA binding protein 1 (ZBP1) is essential for host defense against a growing number of viruses, including herpes simplex virus 1 (HSV-1). Studies with HSV-1 and other necroptogenic stimuli in murine settings have suggested that ZBP1 triggers necroptosis by directly complexing with the kinase RIPK3. Whether this is also the case in human cells, or whether additional co-factors are needed for ZBP1-mediated necroptosis, is unclear.

Home blood pressure during night-time sleep - a feasible treatment target for patients with hypertension: a proof-of-concept randomised controlled trial.

Background: This trial assessed the feasibility of titrating evening dosing of anti-hypertensive medications based on nighttime home blood pressure measurement (HBPM) readings in primary care for hypertensive (HT) patients.

Methods: 78 patients with nocturnal HT and stage I daytime HT were randomly assigned in a 1:1 ratio to either nighttime HBPM measurements (intervention group) or daytime HBPM measurements (control group). Nighttime blood pressure (BP) was measured 3x per night for at least two nights over 1 week using an automatic and validated HBPM device.

Inflammatory Response and Anti-Inflammatory Treatment in Persistent Inflammation-Immunosuppression-Catabolism Syndrome (PICS).

Many patients now survive their initial critical events but subsequently develop chronic critical illness (CCI). CCI is characterized by prolonged hospital stays, poor outcomes, and significant long-term mortality. The incidence of chronic critical illness (CCI) is estimated to be 34.

A Natural Antioxidant Organic Material Modifying the Buried Interface To Regulate the Photovoltaic Performance and Stability of Pure Tin-Based Perovskite Solar Cells.

Despite showing great potential in lead-free green energy, tin-based perovskite materials still face challenges such as inherent material instability and energy level misalignment with the hole transport layer (HTL), which limits the advancement of tin-based perovskite solar cells (Sn-PSCs). In this work, a natural antioxidant organic small molecule, thiolactic acid (TA), is used to modify the interface between PEDOT:PSS and the tin-based perovskite film. The TA molecule can cross-link to form a network polymer and regulate the microstructure and photoelectrical characteristics of PEDOT:PSS.

Analysis of dynamic flavor changes of volatile and non-volatile fractions analysis of black qingke (Hordeum vulgare L. var. nudum Hook. f.) during steaming process.

Qingke (Hordeum vulgare L. var. nudum Hook.

PdNi Trimer Sites Drive Efficient and Durable Hydrogen Oxidation in Alkaline Media.

Anion-exchange membrane fuel cell (AEMFC) is a cost-effective hydrogen-to-electricity conversion technology under a zero-emission scenario. However, the sluggish kinetics of the anodic hydrogen oxidation reaction (HOR) impedes the commercial implementation of AEMFCs. Here, we develop a Pd single-atom-embedded NiN catalyst (Pd/NiN) with unconventional PdNi trimer sites to drive efficient and durable HOR in alkaline media.

Experience-dependent reorganization of inhibitory neuron synaptic connectivity.

Organisms continually tune their perceptual systems to the features they encounter in their environment. We have studied how ongoing experience reorganizes the synaptic connectivity of neurons in the olfactory (piriform) cortex of the mouse. We developed an approach to measure synaptic connectivity , training a deep convolutional network to reliably identify monosynaptic connections from the spike-time cross-correlograms of 4.

Thymoquinone as a potent antimicrobial agent against Yersinia enterocolitica: Mechanisms of action and potential food safety applications.

Yersinia enterocolitica (Y. enterocolitica) is a Gram-negative foodborne pathogen associated with potentially fatal diseases. Herein, the antibacterial activity and possible mechanism of thymoquinone (TQ) against Y.

An endoplasmic reticulum and lipid droplets dual-localized strategy to develop small molecular photosensitizers that induce ferroptosis during photodynamic therapy.

Organelle-localized photosensitizers have been well-developed to enhance the photodynamic therapy (PDT) efficacy through triggering given cell death. The endoplasmic reticulum (ER) and lipid droplets (LDs) are two key organelles mutually regulating ferroptosis. Thus, in this study, small molecular photosensitizer CAR PSs were developed through fragment integration strategy and the heavy-atom modification.

Isolation and Evaluation of Potential Use of Prebiotics-Utilizing Butyrate-Producing Bacteria in .

Butyrate-producing bacteria (BPB) benefit the health of aquatic animals. This current study aimed to isolate BPB from the intestines of and assess their probiotic potential. The results showed that nine isolates were obtained in vitro from the gut of , including six , two , and one .

lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke.

Cardiac myxoma (CM) is an important aetiology of stroke in young adults, and its diagnosis is difficult in patients having stroke because of the lack of diagnostic biomarkers. Tumour-derived exosomes play a crucial role in tumour growth, metastasis, immune regulation, and monitor disease development. Hence,we established an RNA-sequencing dataset for long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) in the plasma and tumour-derived exosomes from four patients with cardiac myxoma-related ischaemic stroke (CM-IS) and six patients with cardiac myxoma without ischaemic stroke (non-IS CM).

High-performance solid-state proton gating membranes based on two-dimensional hydrogen-bonded organic framework composites.

Biological ion channels exhibit strong gating effects due to their zero-current closed states. However, the gating capabilities of artificial nanochannels have typically fallen short of biological channels, primarily owing to the larger nanopores that fail to completely block ion transport in the off-states. Here, we demonstrate solid-state hydrogen-bonded organic frameworks-based membranes to achieve high-performance ambient humidity-controlled proton gating, accomplished by switching the proton transport pathway instead of relying on conventional ion blockage/activation effects.

Inhibition of TFAM-Mediated Mitophagy by Oroxylin A Restored Sorafenib Sensitivity Under Hypoxia Conditions in HepG2 Cells.

Liver cancer treatment encounters considerable therapeutic challenges, especially because hypoxic microenvironments markedly reduce sensitivity to chemotherapeutic agents. TFAM (mitochondrial transcription factor A) plays a crucial role in maintaining mitochondrial function. Oroxylin A (OA), a flavonoid with potential therapeutic properties, demonstrated prospects in cancer treatment.

Improving Corrosion Resistance of Rare Earth Zirconates to Calcium-Magnesium-Alumina-Silicate Molten Salt Through High-Entropy Strategy.

The erosion caused by high-temperature calcium-magnesium-alumina-silicate (CMAS) has emerged as a critical impediment to the advancement of thermal barrier coating (TBC). In this study, a series of high-entropy rare earth zirconates, (LaSmDyErGd)(ZrCe)O ( = 0, 0.2, 0.

Tumor microenvironment-responsive engineered hybrid nanomedicine for photodynamic-immunotherapy via multi-pronged amplification of reactive oxygen species.

Reactive oxygen species (ROS) is promising in cancer therapy by accelerating tumor cell death, whose therapeutic efficacy, however, is greatly limited by the hypoxia in the tumor microenvironment (TME) and the antioxidant defense. Amplification of oxidative stress has been successfully employed for tumor therapy, but the interactions between cancer cells and the other factors of TME usually lead to inadequate tumor treatments. To tackle this issue, we develop a pH/redox dual-responsive nanomedicine based on the remodeling of cancer-associated fibroblasts (CAFs) for multi-pronged amplification of ROS (ZnPP@FQOS).

An Ultrastable Integrated Anode with ∼95 wt.% SiO via In Situ Electrode-Scale Conformal Coating.

SiO-based anodes, considered the most promising candidate for high-energy density batteries, have long been bothered by mechanical integrity issues. Research efforts focus on particle modifications, often overlooking the enhancement of interparticle connections, which can reduce the active material content within the electrode. Herein, an integrated electrode with strong covalent bonding at the electrode scale is designed, achieving excellent mechanical stability with ∼95 wt.

Synergistic effects of butyrate-producing bacteria (Clostridium senegalense I5 or Paraclostridium benzoelyticum G5) and Gracilaria lemaneiformis-originated polysaccharides on the growth and immunity of rabbitfish.

This study evaluated the synergistic effects of dietary butyrate-producing bacteria (Clostridium senegalense I5 (I5) and Paraclostridium benzoelyticum G5 (G5) and Gracilaria lemaneiformis-derived polysaccharide (GLP) in rabbitfish (Siganus canaliculatus). Both bacterial strains demonstrated high susceptibility to most antibiotics, salt tolerance up to 6.5 %, pH tolerance ranging from 2 to 10, and strong auto-aggregation abilities.

Thermal Shielding GdTaO-Based Thermal Barrier Ceramic with Ultralow NIR Transmittance.

Most thermal barrier coating materials exhibit transparent/semi-transparent properties at higher temperatures, causing the surface heat flow to directly heat the substrate with infrared radiation, which significantly reduces the thermal barrier effectiveness. Herein, composite ceramic materials composed of GdFeO diffusely dispersed within the GdTaO are produced. Specifically, the 0.

Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy.

A long-standing debate in neuroscience concerns whether individual neurons are organized into functionally distinct populations that encode information differently ("categorical" representations [1-3]) and the implications for neural computation. Here, we systematically analyzed how cortical neurons encode cognitive, sensory, and movement variables across 43 cortical regions during a complex task (14,000+ units from the International Brain Laboratory public Brain-wide Map data set [4]) and studied how these properties change across the sensory-cognitive cortical hierarchy [5]. We found that the structure of the neural code was scale-dependent: on a whole-cortex scale, neural selectivity was categorical and organized across regions in a way that reflected their anatomical connectivity.

Protocol for the symmetry manipulation of gyroidal mesostructures through the binary self-assembly of block copolymer and cationic surfactant.

New symmetries of the gyroid (G) surfaces are the key to their intriguing properties. Here, we present a protocol to create a tetragonal gyroid substructure (shifted tG) outside the traditional cubic symmetry of G surfaces. We describe steps for employing a binary self-assembly system consisting of block copolymers and surfactants.

Association of cardiorespiratory fitness with dementia risk across different levels of genetic predisposition: a large community-based longitudinal study.

Objective: We aimed to investigate the association of cardiorespiratory fitness (CRF) with cognitive function and dementia risk, taking genetic predisposition for dementia into account.

Methods: Within the UK Biobank, 61 214 dementia-free participants aged 39-70 years were followed for up to 12 years. CRF score was estimated using a 6 min submaximal exercise test on a stationary bike and divided into tertiles (ie, low, moderate, and high; standardised by age and sex).

Unraveling the influence of boiling time on aroma generation in ( Maxim.) water during boiling through molecular sensory science.

water (HW) has a wide range of applications in the new food service industry. However, few process and flavor studies have been conducted on HW. The aim of this study was to investigate the effect of boiling process on HW flavor as well as the mechanisms by which important aroma compounds affect the flavor.

Transcriptomics reveal the involvement of reactive oxygen species production and sequestration during stigma development and pollination in .

Stigma development and successful pollination are essential for the continuous existence of flowering plants. However, the specific mechanisms regulating these important processes are not well understood. In this study, we investigated the development of the stigma in , dividing it into three stages: S1, S2, and S3.