Publications by authors named "Shuqi Tao"
Article Synopsis
- The study explored the toxicity and mechanisms of two synthetic cannabinoids, JWH-018 and JWH-019, in mice, zebrafish, and human kidney cells, despite the lack of information linking their chemical structures to toxicity.
- JWH-018 caused significant cannabinoid-like effects in mice and anxiogenic behaviors in zebrafish, which were blocked by a specific receptor antagonist, while JWH-019 did not produce similar effects.
- Molecular docking revealed key amino acids in the cannabinoid receptor (CB1R) that influence how these substances interact with the receptor, highlighting important differences in their binding and activation mechanisms.
NLRP3 Inflammasome: An Emerging Therapeutic Target for Alzheimer's Disease.
J Alzheimers Dis
December 2023
Alzheimer's disease (AD) is currently the most prevalent neurological disease, and no effective and practical treatments and therapies exist. The nucleotide-binding oligomerization domain-, leucine-rich repeat-, and pyrin domain- containing receptor 3 (NLRP3) inflammasome is vital in the human innate immune response. However, when the NLRP3 inflammasome is overactivated by persistent stimulation, several immune-related diseases, including AD, atherosclerosis, and obesity, result.
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- Exophytic papillary urothelial neoplasms (EPUN) have varied prognoses and can be hard to diagnose, highlighting the need for better diagnostic markers like PHH3, which reflects mitotic activity in tumors.
- This study assessed PHH3 expression in different types of EPUN (high-grade, low-grade, low malignant potential, and papilloma) and compared it with other proteins, Ki67 and P53, using a sample of 101 cases.
- Findings indicated that PHH3 correlates strongly with mitotic counts and Ki67 across various EPUN types, suggesting its potential role in diagnosing and predicting outcomes for these tumors.
The role of leucine-rich alpha-2-glycoprotein-1 in proliferation, migration, and invasion of tumors.
J Cancer Res Clin Oncol
February 2022
Background: Leucine-rich alpha-2-glycoprotein-1 (LRG1) is widely involved in proliferation, migration, and invasion of various tumor cells. Recent studies have evaluated the potential of LRG1 as both an early tumor and a prognostic biomarker.
Method: The relevant literature from PubMed is reviewed in this article.