Publications by authors named "Shuqi Shen"

Article Synopsis
  • Hyperlipidemic acute pancreatitis (HAP) is an inflammatory condition linked to lipid metabolism disorders, and reducing blood triglycerides can help treat it.
  • A new mesoporous silica nanoparticle was created, modified with IL-6 aptamer and lipase, to capture the inflammatory factor IL-6 and decompose triglycerides more effectively in patients with HAP.
  • The nanoparticles demonstrated significant efficiency, capturing IL-6 at about 9.67 pg/mL and decomposing triglycerides at around 3.88 mg/mL within 2 hours, and were used to design an absorption device for improved treatment of HAP using plasma exchange technology.
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Background: Lung cancer is the leading prevalent form of human cancer and has the highest mortality rate among all cancer types. The role and potential mechanism of the lung microbiome in lung cancer is still unknown. This study aims to investigate the microbiomes of lung cancer patients possessing different levels of infiltrated CD8 T cells and programmed cell death-1 (PD-1) receptors, and further assess the correlation between specific microbes and the immune environment of lung tumor.

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The current wound healing process faces numerous challenges such as bacterial infection, inflammation and oxidative stress. However, wound dressings used to promote wound healing, are not well suited to meet the clinical needs. Hyaluronic acid (HA) not only has excellent water absorption and good biocompatibility but facilitates cell function and tissue regeneration.

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Article Synopsis
  • Multidrug resistance (MDR) in cancer treatment is primarily caused by the over-expression of breast cancer resistance protein (BCRP), which makes tumors resistant to chemotherapy.
  • A new high-throughput screening (HTS) system was developed using styrene maleic acid (SMA) to stabilize membrane proteins and a surface plasmon resonance (SPR) biosensor, allowing for effective identification of BCRP inhibitors.
  • The study successfully screened 26 natural products and identified three compounds (xanthotoxin, bergapten, and naringenin) that improved the effectiveness of the chemotherapy drug mitoxantrone in cells with BCRP, highlighting the system's rapid and specific screening capabilities.
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Acute pancreatitis (AP) is a common and serious acute inflammatory disease with high severity rate and mortality. Inflammation and oxidative stress play an extremely important role in the development of AP disease. Polyvinylpyrrolidone-modified iridium nanoparticles (IrNP-PVP) have multienzyme mimetic activity, and the aim of this article is to discuss the therapeutic alleviative effects of the ultrasmall nanozymes IrNP-PVP on AP through their antioxidant and anti-inflammatory effects.

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To tackle the aggravating electromagnetic wave (EMW) pollution issues, high-efficiency EMW absorption materials are being urgently explored. The FeSiCr soft magnetic alloy is one of the more widely used and well-received iron-based soft magnetic alloy materials with high permeability; however, the development of high-performance FeSiCr alloy wave-absorbing materials is still a major challenge. In this study, double core-shell-structured composites of MIL-88(Fe)@FeO@FeSiCr were successfully prepared by the oxidative heat treatment of the flaky FeSiCr obtained after ball milling and then composited with MIL-88(Fe).

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A series of symmetrical truxene-centered and 3-ethylrhodanine end-capped electron acceptors with high absorption coefficient, namely Tr(Hex)-3RD, Tr(Dec)-3RD, and Tr(Hex)-6RD, were prepared and constructed for non-fullerene solar cells. To satisfy solution-processability, multiple energy levels, and suitable morphology, these three acceptors were comparatively studied through alkyl chain (hexyl/decyl) and branched-arm engineering (three/six branched arms). The six-bladed propeller acceptor of Tr(Hex)-6RD recorded the power conversion efficiency (PCE) of 1.

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