Prognostic Implications of the Number of Lymph Node Metastases in Oral Tongue Squamous Cell Carcinoma: A Population Study of the SEER Database and an Institutional Registry.

Background: To investigate the impact of the number of positive lymph nodes (PLNs) on long-term survival and pathological nodal stage in patients with oral tongue squamous cell carcinoma (OTSCC).

Materials And Methods: Newly diagnosed and nonmetastatic adult patients with OTSCC who underwent curative resection were identified between January 2010 and December 2020. External validation was performed via the SEER registry.

Retinoic Acid-Related Orphan Receptor Alpha May Regulate the State of Hair Follicle Stem Cells by Upregulating the Expression of BNIP3.

The hair, an exclusive keratinized dermal appendage in mammals, stands as a quintessential outcome of adaptive evolution, conferring resilience against adverse environmental conditions. The ontogenesis of the coat displays a pronounced rhythmic pattern, with hair follicle stem cells (HFSCs) emerging as pivotal facilitators of hair follicle reconstitution. The retinoic acid-related orphan receptor alpha, a nuclear receptor with extensive involvement in the regulation of cellular physiological states, exerts its functions predominantly through the modulation of downstream target gene transcription.

Dissociative triple ionization of argon dimers in elliptically polarized two-color laser fields.

Using ion-ion coincidence measurements, we experimentally investigate the dissociative triple ionization of argon dimers in relative phase controlled elliptically polarized two-color femtosecond laser fields. By examining the kinetic energy release-dependent momentum angular distribution of the ejected ionic fragments, two distinct pathways, each associated with different intermediates, are identified. Control over the emission directions of the ionic fragments is achieved by varying the relative phase of the elliptical two-color laser fields.

X-ray induced in-situ ferroptosis through the Fenton reaction of iron supplements for the cancer therapy.

The potential of iron-based therapeutic agents in enhancing radiotherapy efficacy through catalyzing the Fenton reaction has garnered widespread interest. The inherent instability of ferrous ions requires the use of complex ligands for the ligand-dependent reduction from Fe to Fe, thereby boosting ferroptosis through inducing the Fenton reaction. However, the reliance on complex redox systems and potential long-term toxicity have seriously limited the clinical application in cancer treatment.

Nickel-catalyzed stereospecific reductive cross-coupling of vinyl chlorosilanes with axially chiral biaryl electrophiles.

Enantioenriched organosilanes are important chiral molecules in materials science and organic synthesis. The synthesis of axially chiral organosilanes is particularly significant in terms of applications. Herein, we report a Ni-catalyzed reductive cross-electrophile coupling of vinyl chlorosilanes with sterically hindered chiral biaryl electrophiles for the synthesis of atropisomeric biaryl organosilanes.

Delayed fragmentation of weakly bound Kr2.

We report the experimental observation of the delayed fragmentation of the weakly bound dimer Kr2+ produced through the single ionization of Kr2 by a femtosecond laser field. The observed time delay between ionization and fragmentation, which reflects the survival time of the resulting Kr2+, is measured on the microsecond timescale. A detailed analysis of the kinetic energy releases of the ejected fragments and photoelectrons suggests that this delayed fragmentation arises from the radiative decay of the long-lived Kr2+, transitioning from the bound state II(1/2u) to the repulsive state I(1/2g).

Multiplexed Target Profiling with Integrated Chemical Genomics and Chemical Proteomics.

Target identification is crucial for elucidating the mechanisms of bioactive molecules in drug discovery. However, traditional methods assess compounds individually, making it challenging to efficiently examine multiple compounds in parallel, especially for structurally diverse compounds. This study reports a novel strategy called chemical genomics-facilitated chemical proteomics (CGCP) for multiplexing the target identification of bioactive small molecules.

Longitudinal changes of serum metabolomic profile after laparoscopic sleeve gastrectomy in obesity.

Background: Bariatric surgery induces significant weight loss, increases insulin sensitivity, and improves dyslipidemia. As one of the most widely performed bariatric surgeries, laparoscopic sleeve gastrectomy (LSG) is thought to improve the metabolic profile along with weight loss. The objective of this study was to evaluate longitudinal changes in the serum metabolite levels after LSG and elucidate the underlying mechanisms of metabolic improvement.

The relationship between risk perceptions and negative emotions in the COVID-19: a meta-analysis.

Background: COVID-19, as a significant public health issue, has had a major impact on the mental health of people worldwide. Research shows a significant positive correlation between individuals' risk perception levels and negative emotions during the outbreak of COVID-19. However, some studies also suggest that the relationship between the two is not significant.

Impact of particle size separation on the stabilisation efficiency of heavy-metal-contaminated soil: a meta-analysis.

The separation of heavy-metal-contaminated soil by particle size is crucial for minimising the volume of contaminated soil because of the pronounced variability in the heavy-metal distribution among different soil particle sizes. However, relevant analyses on the effect of soil particle size sorting on stabilisation are limited. Therefore, we screened 2766 peer-reviewed papers published from January 2010 to April 2022 in the Web of Science database, of which 117 met the screening requirements, and conducted a meta-analysis to explore how soil particle size sorting and the interaction between sorting particle size and soil properties affect the stabilisation of heavy metals.

Too much of a good thing? A multilevel examination of listening to music at work.

Music listening has proliferated in the workplace, yet its effects have been overlooked, and classic investigations offer conflicting results. To advance our understanding, we draw from self-regulation and resource allocation theories to suggest that listening to music has curvilinear effects on attentional focus and performance on work tasks and that willpower belief is a key boundary condition. We test these hypotheses across three studies: a pilot study of 108 employees from a software company who took part in a 2-week experience-sampling methodology study and self-rated their music listening and performance, a laboratory study (Study 1) of 252 undergraduate students in which task attentional focus and objective performance on proofreading tasks were captured across repeated trials while listening to music, and a 3-week experience-sampling methodology study (Study 2) of 247 employees that included a within-person manipulation of music listening (little to no music vs.

Custom-printed microfluidic chips using simultaneous ratiometric fluorescence with "Green" carbon dots for detection of multiple antibiotic residues in pork and water samples.

In the evolving field of food safety, rapid and precise detection of antibiotic residues is crucial. This study aimed to tackle this challenge by integrating advanced inkjet printing technology with sophisticated microfluidic paper-based analytical devices (µPADs). The µPAD design utilized "green" quantum dots synthesized via an eco-friendly hydrothermal method using green white mulberry leaves as the carbon source, serving as the key fluorescent detection material.

A systematic review on botany, ethnopharmacology, phytochemistry and pharmacology of Potentilla anserina L.

Ethnopharmacological Relevance: Potentilla Anserina Linnaeus, a traditional Chinese herb with ethnic characteristics, is considered a superior material by the people of Qinghai and Tibet. Traditionally, it has been used to invigorate the spleen, quench thirst, tonify the blood, astringing to stop bleeding, and relieve diarrhea. This is the reason for its frequent usage in treating spleen deficiency, diarrhea, and various bleeding disorders.

Janus and Amphiphilic MoS 2D Sheets for Surface-Directed Orientational Assemblies toward Ex Vivo Dual Substrate Release.

The two-dimensional (2-D) Janus and amphiphilic molybdenum disulfide (MoS) nanosheet with opposite optical activities on each side (amphichiral) is synthesized by modifying sandwich-like bulk MoS with tannic acid and cholesterol through biphasic emulsion method. This new type of amphichiral Janus MoS nanosheet consists of a hydrophilic and positive optical activity tannic acid side as well as a hydrophobic and negative optical activity cholesterol side thereby characterized by circular dichroism. Surface-directed orientational differentiation assemblies are performed for the as-synthesized 2D material and are characterized by contact angle, infrared spectroscopy, X-ray photoelectron, and circular dichroism spectroscopies.

A novel fully automatic segmentation and counting system for metastatic lymph nodes on multimodal magnetic resonance imaging: Evaluation and prognostic implications in nasopharyngeal carcinoma.

Background: The number of metastatic lymph nodes (MLNs) is crucial for the survival of nasopharyngeal carcinoma (NPC), but manual counting is laborious. This study aims to explore the feasibility and prognostic value of automatic MLNs segmentation and counting.

Methods: We retrospectively enrolled 980 newly diagnosed patients in the primary cohort and 224 patients from two external cohorts.

Phase unwrapping algorithm based on phase diversity wavefront reconstruction and virtual Hartmann-Shack technology.

Phase unwrapping (PU) algorithms play a crucial role in various phase measurement techniques. Traditional algorithms cannot work well in strong noise environments, which makes it very difficult to obtain the accurate absolute phase from the noisy wrapped phase. In this Letter, we introduce a novel, to the best of our knowledge, phase unwrapping algorithm named PD-VHS.

Radiomics-based lymph nodes prognostic models from three MRI regions in nasopharyngeal carcinoma.

Accurate prediction of the prognosis of nasopharyngeal carcinoma (NPC) is important for treatment. Lymph nodes metastasis is an important predictor for distant failure and regional recurrence in patients with NPC. Traditionally, subjective radiological evaluation increases concerns regarding the accuracy and consistency of predictions.

High expression of SRSF1 facilitates osteosarcoma progression and unveils its potential mechanisms.

Background: SRSF1, a member of Serine/Arginine-Rich Splicing Factors (SRSFs), has been observed to significantly influence cancer progression. However, the precise role of SRSF1 in osteosarcoma (OS) remains unclear. This study aims to investigate the functions of SRSF1 and its underlying mechanism in OS.

Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer's disease mouse models.

The gut microbiota and microglia play critical roles in Alzheimer's disease (AD), and elevated Bacteroides is correlated with cerebrospinal fluid amyloid-β (Aβ) and tau levels in AD. We hypothesize that Bacteroides contributes to AD by modulating microglia. Here we show that administering Bacteroides fragilis to APP/PS1-21 mice increases Aβ plaques in females, modulates cortical amyloid processing gene expression, and down regulates phagocytosis and protein degradation microglial gene expression.

Constructing an Open-Structured J-Type ZnInS/In(OH) Heterojunction for Photocatalytical Hydrogen Generation.

Constructing heterojunctions to separate photogenerated carriers is an effective strategy for improving the efficiency of photocatalytic reactions. A J-type heterojunction is a recently reported efficient anisotropic heterojunction. Herein, taking anisotropic ZnInS (ZIS) nanosheets as an example of a type-II heterojunction, we report for the first time the concept of open and closed structures (O and C structure) of J-type heterojunctions.