Another inner truth of shaking: Water migration and transformation-advanced physicochemical alterations in tea leaves.

Shaking, essential in oolong tea production, is becoming an innovative method to impart floral fragrance. Research on shaking primarily concentrates on biological underpinnings, including modifications in gene expression and stress-triggered enzymatic catalysis, and consequent physicochemical properties. Water phase and distribution, reshaped by shaking and affected the biological and physicochemical alterations of tea leaves, is always ignored.

Predicting Agents That Can Overcome 5-FU Resistance in Colorectal Cancers via Pharmacogenomic Analysis.

5-Fluorouracil (5-FU) is one of several chemotherapeutic agents in clinical use as a standard of care to treat colorectal cancers (CRCs). As an antimetabolite, 5-FU inhibits thymidylate synthase to disrupt the synthesis and repair of DNA and RNA. However, only a small proportion of patients benefit from 5-FU treatment due to the development of drug resistance.

Overexpression of miR-194 Reverses HMGA2-driven Signatures in Colorectal Cancer.

Unlabelled: Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide with increasing incidence and mortality in developed countries. Oncogenes and microRNAs regulate key signaling pathways in CRC and are known to be deregulated. Oncogenic transcriptional regulator high-mobility group AT-hook 2 (HMGA2) participates in the transformation of several cancers including CRC and exhibits strong correlation with poor prognosis and distal metastasis.

Neural activity in monkey dorsal and ventral cingulate motor areas: comparison with the supplementary motor area.

The cingulate motor areas are a recently discovered group of discrete cortical regions located in the cingulate sulcus with direct connections to the primary motor cortex and spinal cord. Although much is known about their anatomical relationship with other motor areas, relatively little is known about their functional neurophysiology. We investigated neural mechanisms of motor processing in the dorsal and ventral cingulate motor areas (CMAd and CMAv) during two-dimensional visually guided arm movements.