Significance and implications of nanoparticle-biological corona fingerprints in diagnosis, prognosis, and therapeutics for diverse disorders.

Upon entering a biological environment, the surface of nanoparticles (NPs) is rapidly coated by various biomolecules (typically proteins), herein referred to as the biological corona fingerprint, representing a rich source of biological information that can guide the development of diagnosis, prognosis, and therapeutics for diverse disorders. Although the number of studies has been increasing and considerable technological success has been achieved over the past few years, the main obstacles in this field stem from the complexities and heterogeneity of disease biology due to an incomplete understanding of nano-bio interactions and the challenges regarding the chemistry, manufacturing, and controls required for clinical translation. This minireview highlights the progress, challenges, and opportunities in nano-biological corona fingerprinting for diagnosis, prognosis, and therapeutics, and offers suggestions for more effective nano-therapeutics by capitalizing on our growing understanding of tumor biology and nano-bio interactions.

Value of conventional ultrasound, ultrasound elasticity imaging, and acoustic radiation force impulse elastography for prediction of malignancy in breast lesions.

Objective: To evaluate the efficacies of conventional ultrasound (US), US elasticity imaging (EI), and acoustic radiation force impulse (ARFI) elastography in breast malignancy diagnosis.

Methods: We included 315 women (mean age, 44 years; range, 18-81 years) with 336 pathologically proven breast lesions in this retrospective study. All lesions underwent conventional US, EI, and ARFI (including virtual touch tissue imaging [VTI], virtual touch tissue quantification [VTQ], and virtual touch tissue imaging and quantification [VTIQ]) elastography.

Acoustic radiation force impulse elastography in evaluation of triple-negative breast cancer: A preliminary experience.

Purpose: To assess the elastographic features of triple-negative breast cancers and evaluate the diagnostic value of acoustic radiation force impulse imaging (ARFI) for the characterization of triple-negative breast cancers.

Materials And Methods: This study analyzed data from 234 women with breast cancer. Patients were categorized into three groups; 1) triple-negative breast cancers (n = 48); 2) ER-positive tumors (n = 128) and 3) HER2-positive tumors (n = 58).

Combination of conventional ultrasonography and virtual touch tissue imaging quantification for differential diagnosis of breast lesions smaller than 10 mm.

Objective: To determine the value of combining conventional ultrasonography with virtual touch tissue imaging quantification (VTIQ) for differential diagnosis of breast lesions smaller than 10 mm.

Methods: A total of 98 breast lesions smaller than 10 mm were examined by conventional ultrasound and VTIQ using a Siemens ACUSON S3000 ultrasound machine. Pathologic diagnosis was established after surgery or fine needle biopsy.