Nano-confined Si@C composites with excellent lithium-ion storage performance derived from a POSS-based covalent framework and low-temperature reduction method.

Silicon-based anode materials experience significant volume changes and low conductivity during the lithiation process, which severely hinders their successful application in lithium-ion batteries. Reducing the size of silicon particles and effectively combining them with carbon-based materials are considered the main strategies to enhance the lithium-ion storage performance of silicon-based anodes. In this study, we employed a "bottom-up" strategy to synthesize Si@C anode materials by cross-linking octa-aminopropyl polyhedral oligomeric silsesquioxane (NH-POSS) with terephthalaldehyde and subsequent high-temperature treatment and low-temperature liquid reduction.

Single-pixel transmission matrix recovery via two-photon fluorescence.

Imaging at depth in opaque materials has long been a challenge. Recently, wavefront shaping has enabled notable advance for deep imaging. Nevertheless, most noninvasive wavefront-shaping methods require cameras, lack the sensitivity for deep imaging under weak optical signals, or can only focus on a single "guidestar.

Reliability and validity of a semi-quantitative food frequency questionnaire: dietary intake assessment among multi-ethnic populations in Northwest China.

Background: Few multi-ethnic dietary culture-sensitive food frequency questionnaires (FFQ) have been developed due to the complexity and diversity of cooking methods and styles. This study aimed to develop and validate a specific FFQ among multi-ethnic groups in Northwest China.

Methods: In the reliability study, 139 participants aged 20-65 completed two identical FFQs separated by 3 months.

Coordination-Modulated Metal Tetrathiafulvalene Octacarboxylate Frameworks for High-Performance Lithium-Ion Battery Anodes.

Modulation of the ligands and coordination environment of metal-organic frameworks (MOFs) has been an effective and relatively unexplored avenue for improving the anode performance of lithium-ion batteries (LIBs). In this study, three MOFs are synthesized, namely, M (o-TTFOB)(bpm) (H O) (where M is Mn, Zn, and Cd; o-H TTFOB is ortho-tetrathiafulvalene octabenzoate; and bpm is 2,2'-bipyrimidine), based on a new ligand o-H TTFOB with two adjacent carboxylates on one phenyl, which allows us to establish the impact of metal coordination on the performance of these MOFs as anode materials in LIBs. Mn-o-TTFOB and Zn-o-TTFOB, with two more uncoordinated oxygen atoms from o-TTFOB , show higher reversible specific capacities of 1249 mAh g and 1288 mAh g under 200 mA g after full activation.

Multi-target object scattering imaging with intensity correlation of structured illumination.

Imaging through scattering layers based on the optical memory effect (OME) concept has been widely investigated in recent years. Among many scattering scenarios, it is very important to recover hidden targets with proper spatial distribution in the scene where multiple targets out of the OME range exist. In this Letter, we put forward a method for multi-target object scattering imaging.

Serum-derived piR-hsa-164586 of extracellular vesicles as a novel biomarker for early diagnosis of non-small cell lung cancer.

Non-small cell lung cancer (NSCLC) is a major cause of death in those with malignant tumors. To achieve the early diagnosis of NSCLC, we investigated serum-derived Piwi-interacting RNA (piRNA) of extracellular vesicles to filter diagnostic biomarkers for NSCLC. High-throughput sequencing from cancerous tissues and adjacent noncancerous tissues in patients with NSCLC was first applied to recognize candidate piRNAs as diagnostic biomarkers.

Generation of Non-Rayleigh Nondiffracting Speckles.

Optical speckle fields with both non-Rayleigh statistics and nondiffracting characteristics in propagation are an important light source for many applications. However, tailoring either non-Rayleigh statistical speckles or nondiffracting speckles are only investigated independently in previous studies. Here, we report the first observation of optical speckles that remain diffraction-free over a long axial distance while keeping non-Rayleigh statistics simultaneously.

Measuring the complex spectrum of orbital angular momentum and radial index with a single-pixel detector.

Typical methods to decode a complex orbital-angular-momentum (OAM) spectrum suffer from issues such as a narrow OAM range, unstable interferometer, and long measuring time. In this Letter, we use a single-beam interferometer to measure the complex OAM spectrum with a single-pixel detector. The complex OAM spectrum ranging from -10 to 10 can be measured in 11 ms with the fidelity approach of 97.

[Overexpression of miR-382-5p Mediated Downregulation of PTEN on Malignant Biological Behavior of Human Glioma U251 Cells].

Objective: To investigate the effect of overexpression of miR-382-5p overexpression on malignant biological behavior of human glioma U251 cells.

Methods: U251 cells were transfected with miR-382-5pmimic. Then miR-382-5p and mRNA levels were detected by reverse transcription-polymerase chain reaction (RT-PCR) after transfection.

Single-pixel foreground imaging without a priori background sensing.

The single-pixel imaging technique, which is significantly different from conventional multi-pixel imaging, utilizes the signal recorded by a single-pixel detector and a stream of structured illumination patterns to reconstruct an image. We design and experimentally demonstrate a real-time single-pixel foreground imaging system with fewer samples and without a priori sensing of the background by performing incremental principal component analysis on online compressed sampling data. A fast ℓ compressed sensing algorithm is adopted to realize real-time foreground imaging of 10 frames per second with an image size of 127 × 127 pixels and a compression ratio of 3%.

Primary breast diffuse large B-cell lymphoma in a patient with systemic lupus erythematosus: A case report and review of the literature.

Rationale: Pilot studies have reported that patients with systemic lupus erythematosus (SLE) appear more likely to develop into neoplasia, especially lymphatic hyperplasia diseases. To our knowledge, this is the first case report of the concomitant onset of SLE and primary breast diffuse large B-cell lymphoma (PB-DLBCL).

Patient Concerns: We reported an unusual case of the occurrence of primary breast diffuse large B-cell lymphoma in a 25-year-old female patient who had been diagnosed with SLE and treated with immunosuppressive drugs for about 4 years.

CREB1-induced miR-1204 promoted malignant phenotype of glioblastoma through targeting NR3C2.

Background: Glioblastoma (GBM) is a subclass of brain malignancy with unsatisfactory prognosis. MicroRNAs (miRNAs) are a group of non-coding RNAs (ncRNAs) that exert key function on tumorigenesis and tumor development.

Purposes: The purpose of this work was to unravel the biological behavior and mechanism of miR-1204 in GBM.

CBX3 promotes glioma U87 cell proliferation and predicts an unfavorable prognosis.

Background: Chromobox protein homolog 3 (CBX3) is one of the heterochromatin protein 1 (HP1) family members. Among multiple cancers, it is usually overexpressed. However, the mechanism and function of CBX3 in glioma remain incompletely illustrated.

Fourier single-pixel reconstruction of a complex amplitude optical field.

Based on a Fourier single-pixel imaging (SPI) technique and interference between an unknown field and a reference beam, we implement amplitude and phase reconstruction of the unknown complex field. In this Letter, we use a chessboard pattern to divide the unknown field into the signal and reference parts. A high-speed digital micro-mirror device is used to modulate the relative phase between the reference and signal fields, and the SPI method is used to acquire the Fourier spectrum of the signal field.

[Nucleocytoplasmic translocation of ING5 protein in breast cancer and its correlation with poor clinicopathological characteristics of breast cancer].

Objective To investigate the nucleocytoplasmic translocation of inhibitor of growth family member 5 (ING5) gene in human breast cancer and the negative correlation between the nuclear high expression of ING5 protein and the clinicopathological characteristics of breast cancer. Methods We collected 260 cases of clinical primary breast cancer, 55 cases of metastatic cancer in lymph node, 61 cases of breast fibroadenoma, 110 cases of adenomatosis, and 91 cases of para-cancerous tissues. With the tissue microarrays, we detected ING5 expression in the nucleus and cytoplasm through immunohistochemistry, and statistically analyzed the correlations of nuclear and cytoplasmic ING5 expression with the clinicopathological characteristics of breast cancer.

The nucleocytoplasmic translocation and up-regulation of ING5 protein in breast cancer: a potential target for gene therapy.

Here, we found that ING5 overexpression resulted in a lower proliferation, reduced glucose metabolism, S arrest, decreased migration and invasion, apoptotic induction, fat accumulation, autophagy, senescence and mesenchymal-epithelial-transition of breast cancer cells. It also suppressed the tumor growth of breast cancer cells by inhibiting proliferation, inducing apoptosis and autophagy. ING5-mediated chemoresistance was positively linked to Akt and NF-κB activation, MRP1 and GST-π overexpression, and FBXW7 hypoexpression.

Nitrogen-doped hollow porous carbon nanospheres coated with MnO nanosheets as excellent sulfur hosts for Li-S batteries.

In this work, nitrogen-doped hollow porous carbon nanospheres coated with MnO nanosheets (NHPC@MnO) were prepared as a novel sulfur host for the cathode of lithium-sulfur battery. N-doping of carbon and deposition of the inherently polar MnO promote chemical binding of the host with sulfur and its reduction products, known as polysulfides. Meanwhile, proper N-doping can improve the electron conductivity of carbon, and the nanosheet structure may help to guarantee facile electron- and lithium-ion transport through MnO.

Rare RET Variant p.D707E in a Chinese Pedigree with Hereditary Medullary Thyroid Carcinoma.

Background: Hereditary medullary thyroid carcinoma (HMTC) is thought to be associated with germline mutations of the RET proto-oncogene.

Methods: We detected RET proto-oncogene germline mutations from a pedigree with HMTC in the east of China and investigated the characteristics of these mutations in this pedigree and their correlation with HMTC by direct sequencing of all 21 exons in the RET gene of all 46 subjects.

Results And Conclusion: (1) Thirteen types of RET gene variants were detected in this pedigree.

[The clinical characteristics and microsurgery treatment of patients with spinal cord glioblastoma].

Objective: The aim is to explore the clinical characteristics of spinal cord glioblastoma and the therapeutic effect of microsurgery.

Methods: The clinical data of 18 patients with spinal cord glioblastoma from January 2011 to December 2014 in Beijing Tiantan Hospital were retrospectively analyzed including the clinical characteristics, the microsurgery treatment and the postoperative radiochemotherapy.

Results: There were 12 cases for subtotal resection, 4 cases for partial resection and 2 cases for biopsy of the intraspinal tumors under microscope.

On the preparation of transferrin modified artesunate nanoliposomes and their glioma-targeting treatment in-vitro and in-vivo.

Objective: To prepare transferrin modified artesunate nanoliposomes (Tf-ART-LPs) and study their glioma U87 cells-targeting treatment in-vitro and in-vivo.

Methods: Ammonium sulfate transmembrane gradient method was used to prepare Tf-ART-LPs, whose size and stability was detected by a Nanosizer. Besides, the encapsulation efficiency and release rate of artesunate (ART) were tested by a ultraviolet spectrophotometer.

[Expression and clinical significance of ING4 and HIF-1 alpha in brain astrocytoma].

Objective: To study the mRNA expression level of growth inhibition factor 4 (ING4) and hypoxia inducing factor 1 alpha (HIF-1 alpha), and their relationship with tumor malignant degree or the pathology classification in human brain astrocytoma.

Methods: The mRNA expression levels of ING4 and HIF-1 alpha were detected by RT-PCR method in 45 cases of grade I-IV human brain astrocytoma and 11 cases of control brain tissues from January 2009 to June 2010 in the Second Affiliated Hospital of Zhengzhou University, and their correlation was also analyzed.

Results: In the non-tumor brain tissue, the expression level of ING4 mRNA was 1.

Inhibitory effect of DNA topoisomerase inhibitor isoliquiritigenin on the growth of glioma cells.

Objective: To investigate the effect of isoliquiritigenin on the activity of DNA topoisomerase (TOP I) and its inhibitory effect on the growth of U87 glioma cells.

Methods: This study investigated the inhibitory effect of isoliquiritigenin on the growth of U87 glioma cells and its cytotoxicity by MTT method and determined the effect of isoliquiritigenin on TOP I activity by agarose gel electrophoresis. On this basis, we studied the interaction between isoliquiritigenin and TOP I and DNA.

Probucol Protects Against Asymmetric Dimethylarginine-Induced Apoptosis in the Cultured Human Brain Microvascular Endothelial Cells.

Asymmetric dimethylarginine (ADMA) is emerging as a key contributor to endothelial dysfunction. The drug probucol was reported to have an anti-lipid peroxidation effect and improve endothelial dilation function. But little is known about the protective effect of probucol on ADMA-induced human brain microvascular endothelial cell (HBMEC) injury and its underlying mechanisms.

Expression of AKAP95, Cx43, CyclinE1 and CyclinD1 in esophageal cancer and their association with the clinical and pathological parameters.

Objective: To investigate correlations among A-kinase anchor protein95 (AKAP95), Connexin43 (Cx43), CyclinE1 and CyclinD1 in esophageal squamous cell cancer tissues, and their relationship with clinical and pathological parameters.

Methods: The protein levels of AKAP95, Cx43, CyclinE1 and CyclinD1 in 54 cases of esophageal squamous cell cancer tissues were determined by immunohistochemistry.

Results: The expression of AKAP95, CyclinE1 and CyclinD1 in esophageal squamous cell cancer tissues (53.