Publications by authors named "Shupeng Song"
Article Synopsis
- Fever of unknown origin can be difficult to diagnose and manage, primarily due to the challenges in identifying the specific infectious disease causing it.
- A case report describes a patient with fever, nausea, and anorexia who underwent various imaging tests but initially did not get a clear diagnosis; surgical exploration ultimately confirmed appendicitis.
- The findings highlight how atypical symptoms and negative tests can lead to underdiagnosis, emphasizing the need for better management strategies for both appendicitis and unexplained fevers.
Article Synopsis
- - Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common liver disease with no approved medications, and this study investigates the potential link between dietary antioxidants (measured by the composite dietary antioxidant index or CDAI) and MASLD.
- - A large analysis using data from over 12,000 participants showed that higher CDAI values were often linked to non-MASLD statuses, with various statistical models suggesting a negative correlation between CDAI and liver stiffness or fat accumulation.
- - Interestingly, while the relationship was linear for females, it was non-linear for males, indicating that gender may influence how dietary antioxidants impact liver health in regard to MASLD, with specific CDAI points highlighting this division.
In the process of a solid-phase immunoassay, the stability and binding orientation between the antibody and the solid matrix can substantially influence the results. ZZ protein is a modified peptide of the B domain of Staphylococcus aureus protein A, which can bind to the Fc fragment of an antibody. It is often used for oriented immobilization of antibodies during solid-phase immunoassay.
View Article and Find Full Text PDFBackground: Chronic alcohol consumption is more frequently associated with advanced, aggressive hepatocellular carcinoma (HCC) tumors. Alcohol adversely impacts ER/Golgi membrane trafficking and Golgi protein N-glycosylation in hepatocytes; these effects have been attributed (in part) to dysregulated adenosine diphosphate-ribosylation factor (ARF) GTPase signaling. Here, we investigated the role of the ARF GTPase guanine exchange factor PSD4 in HCC progression.
View Article and Find Full Text PDFCurrent polymeric transfer methods of 2D materials often bring about the presence of wrinkles, cracks, and polymer residue, limiting the quality of the transferred materials and performance of devices. Herein, we report a transfer approach combining pretreatment by liquid nitrogen and lithium ion intercalation with polymer composite of small molecules and polystyrene to achieve high-fidelity transfer of 2D transition metal dichalcogenides (TMDs) grown by chemical vapor deposition. In this method, the as-grown samples were pretreated by liquid nitrogen and lithium ion intercalation to weaken the bonding between the TMD and the substrate.
View Article and Find Full Text PDFAlthough the existence of cancer stem cells (CSCs) has been suggested in diffuse large B cell lymphoma (DLBCL), there is still no definitive marker. CD45CD19 has been regarded as a potential marker of CSCs in mantle cell lymphoma (MCL). So, we explored the role of CD45CD19 in DLBCL.
View Article and Find Full Text PDFHepatitis B core antigen (HBcAg) possesses unusual immunologic features. However, the biological roles and mechanisms of HBcAg in dendritic cell proliferation and apoptosis remain to be elucidated. In the present study, DC2.
View Article and Find Full Text PDFBACKGROUND Hepatitis B virus (HBV) is a hepatotropic virus that can infect extrahepatic tissue. Whether hematopoietic stem cells (HSCs) can be infected by HBV and serve as a potential virus reservoir is still unknown. In this study, the susceptibility of CD34+ HSCs to HBV was investigated.
View Article and Find Full Text PDFIncreasing evidence indicates that the hepatitis B virus (HBV) replicates in peripheral blood mononuclear cells (PBMCs), but at a low level. The present study aimed to establish a reliable and sensitive method that effectively detects HBV viral products for monitoring antiviral therapy, organ transplantation screening, and diagnosing occult HBV infection. In the present study, PBMCs (obtained from six healthy volunteers) were inoculated with HBV, and cultured with phytohemagglutinin (PHA) and interleukin‑2 (IL‑2) to stimulate cell proliferation.
View Article and Find Full Text PDFBackground: The mechanisms leading to virus-specific CD8+ T cell dysfuction in chronic hepatitis B virus (HBV) infection remain to be elucidated. Our study focused on the role of transcription factor T-bet in HBV infection because it is a crucial regulator of T cell immunity.
Methods: We assessed the expression of T-bet along with PD-1, IFN-γ and perforin, in HBV-specific CD8+ T cells from resolved acute hepatitis B (rAHB) patients, chronic hepatitis B (CHB) patients, as well as asymptomatic HBV carriers (ASCs).