Publications by authors named "Shuojiao Li"
Objective: Endoplasmic reticulum stress (ERS) plays an important role in the development of Alcoholic liver injury (ALI), but the exact mechanism needs further exploration. This study aims to investigate the role of ERS-XBP1s in ALI, and providing new target for the treatment of liver injury.
Method: The ALI model was constructed using the NIAAA method and was validated by several methods.
Macrophages show high plasticity and play a vital role in the progression of metabolic dysfunction-associated steatohepatitis (MASH). X-box binding protein 1 (XBP1), a key sensor of the unfolded protein response, can modulate macrophage-mediated pro-inflammatory responses in the pathogenesis of MASH. However, how XBP1 influences macrophage plasticity and promotes MASH progression remains unclear.
View Article and Find Full Text PDFObjective: The aim of this study was to establish a simple and sensitive high-performance liquid chromatography method for therapeutic drug monitoring of venetoclax (VEN) and optimize regimens.
Methods: The analysis required the extraction of a 50 μl plasma sample and the precipitation of proteins using acetonitrile extraction. The chromatographic method employed a mobile phase of acetonitrile: 0.
Article Synopsis
- The gut microbiota is important in developing a liver disease called non-alcoholic steatohepatitis (NASH), but how it all works isn't clear yet.
- A study used mice on a special diet to create a model for NASH and found that certain gut bacteria changed their levels during the disease stages.
- A treatment called FT@XBP1 helped improve the gut bacteria balance and protected the intestinal barrier, which in turn may help reduce the effects of NASH.