Targets and mechanisms of Miquel fruits in treating neurodegenerative dementia.

The dried and ripe fruits of and ripe fruits of Miquel (AO) have the effects of tonifying kidney-essence and nourishing intelligence and thus have been widely used in treating dementia. Alzheimer's disease (AD) is a typical form of neurodegenerative dementia with kidney-essence deficiency in Traditional Chinese Medicine (TCM). So far, there is a lack of systematic studies on the biological basis of tonifying kidney-essence and nourishing intelligence and the corresponding phytochemicals.

A Tau Pathogenesis-Based Network Pharmacology Approach for Exploring the Protections of in Alzheimer's Disease.

Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia and one of the top medical concerns worldwide. Currently, the approved drugs to treat AD are effective only in treating the symptoms, but do not cure or prevent AD. Although the exact causes of AD are not understood, it is recognized that tau aggregation in neurons plays a key role.

Therapeutic Mechanism and Key Alkaloids of in Alzheimer's Disease From the Perspective of Pathophysiological Processes.

Presently, there is a lack of effective disease-modifying drugs for the treatment of Alzheimer's disease (AD). (UR) and its predominant active phytochemicals alkaloids have been studied to treat AD. This study used a novel network pharmacology strategy to identify UR alkaloids against AD from the perspective of AD pathophysiological processes and identified the key alkaloids for specific pathological process.