Developing an advanced course of vaccinology in middle-income countries: The case of China.

•We provide the Chinese Vaccinology Course was the only national advanced vaccinology training course in China, in response to the global call to improve vaccine capacity and meet local needs.•To address the challenges for both the development of the country as well as world sustainability and to address the major needs of the country and for the lives and health of the people.•Science and technology has provided strong support in controlling infection, developing vaccines and promoting drug research and development (R& D), CNVAC provide model problems and solutions for the research community.

Adipose derived mesenchymal stem cell-seeded regenerated silk fibroin scaffolds reverse liver fibrosis in mice.

Liver fibrosis (LF) is an important process in the progression of chronic liver disease to cirrhosis. We have previously demonstrated that a regenerated silk fibroin scaffold loaded with adipose-derived stem cells (RSF + ADSCs) can repair acute liver injury. In this study, we established a chronic LF animal model using carbon tetrachloride (CCl) and a high-fat diet.

Atomic Engineering and Aggregation Effect to Regulate Synergistically Type I Reactive Oxygen Species of AIE-Active Deep Red/Near Infrared Red Photosensitizer.

"Molecular science" has long been regarded as the golden rule to guide the design of organic materials' performances in the past many years, but some interesting phenomena of conventional aggregation-caused fluorescence quenching and new aggregation-induced emission reflect that materials' properties would be changed from "molecule" to "aggregate". Therefore, "molecular science" theory faces certain limitations to guide regulating the performance of materials at aggregation. In this work, it is discovered that the photosensitizer's performances contain fluorescence and reactive oxygen species, which could be affected by changing molecular atoms and aggregation form.

Comparison of the Immune Enhancing Activity and Chemical Constituents Between Imitation Wild and Cultivated Astragali Radix.

Astragali Radix (AR), a traditional food and medicinal herb used for thousands of years, is widely recognized for its role in enhancing immunity, particularly when combined with adjuvant chemotherapy. The two primary types of AR available in the market are imitation wild AR (grown for seven years) and cultivated AR (grown for two years). However, whether differences exist in their immune-enhancing effects and chemical constituents remains unclear.

The aggressive driving performance caused by congestion based on behavior and EEG analysis.

Introduction: Traffic congestion is closely related to traffic accidents, as prolonged traffic congestion often results in frustration and aggressive behavior. Moreover, in daily commuting, drivers often have to pass through multiple congested road sections, and aggressive driving performance due to exiting or re-entering traffic jams has rarely been analyzed.

Method: To fill this research gap, we designed an intermittent traffic congestion scenario using a driving simulator and employed unsupervised learning algorithms to extract high-level driving patterns gathered with EEG data to investigate the continuous effects of traffic jams, particularly when drivers exit and re-enter traffic jam conditions.

Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology.

Infection with enterohemorrhagic E. coli (EHEC) causes severe changes in the brain leading to angiopathy, encephalopathy and microglial activation. In this study, we investigated the role of tumour necrosis factor alpha (TNF-α) for microglial activation and brain pathology using a preclinical mouse model of EHEC infection.

Negative association between 15 obesity- and lipid-related indices and testosterone in adult males: a population based cross-sectional study.

Background: An association exists between obesity and reduced testosterone levels in males. The propose of this research is to reveal the correlation between 15 indices linked to obesity and lipid levels with the concentration of serum testosterone, and incidence of testosterone deficiency (TD) among adult American men.

Methods: The study utilized information gathered from the National Health and Nutrition Examination Survey (NHANES) carried out from 2011 to 2016.

Comparative Efficacy of Esketamine vs Sufentanil with Propofol for Sedation in EUS: A Randomized, Controlled Study.

Purpose: This randomized, controlled trial aimed to assess the sedative effects of esketamine and sufentanil combined with propofol during EUS.

Patients And Methods: Three hundred and forty patients undergone EUS were randomly divided into two groups to receive esketamine 0.25 mg/kg combined with propofol (esketamine group) or sufentanil 0.

Metal-organic cage crosslinked nanocomposites with enhanced high-temperature capacitive energy storage performance.

Polymer dielectric materials are widely used in electrical and electronic systems, and there have been increasing demands on their dielectric properties at high temperatures. Incorporating inorganic nanoparticles into polymers is an effective approach to improving their dielectric properties. However, the agglomeration of inorganic nanoparticles and the destabilization of the organic-inorganic interface at high temperatures have limited the development of nanocomposites toward large-scale industrial production.

Increased antimicrobial resistance of isolates obtained from children in Beijing, China, in 2023.

Introduction: (), a common pathogen of community-acquired pneumonia in school-age children and adolescents, can cause epidemics worldwide. In late 2023, the incidence of infection among children reached a high level.

Methods: We investigated the antimicrobial susceptibility of 62 isolates obtained from children with pneumonia in Beijing between 2021 and 2023, and analyzed the correlation of antimicrobial susceptibility with molecular characteristics of isolates and clinical manifestations of patients.

Research and development of new intelligent foaming and discharging agent system.

The application of classic foaming agent faces several issues, including excessive use of defoaming agent, inadequate defoaming, pipeline blockage due to silicone oil precipitation, and high development cost of the foaming agent. To address the aforementioned issues, a novel intelligent foaming agent was created. This resulted in the development of a new intelligent foaming and discharging agent system.

The dynamic triage interplay of Hsp90 with its chaperone cycle and client binding.

Hsp90, a crucial molecular chaperone, regulates diverse client proteins, impacting both normal biology and disease. Central to its function is its conformational plasticity, driven by ATPase activity and client interactions. However, comprehensive insights into Hsp90's dynamic molecular transitions remain elusive.

The relationship between dyadic coping and post-traumatic growth in breast cancer patients and spouses: based on potential profile analysis.

Background: The disease impact of breast cancer is to view the couple as a whole, breast cancer is a disease shared by the couple. Cancer coping has evolved from an individual perspective to a dyadic coping perspective for couples. The purpose of this study was to identify and describe the dyadic coping categories of couples with breast cancer and to analyze the relationship between dyadic coping categories and post-traumatic growth (PTG) in couples with breast cancer.

The Potential of ESCO2 as a Prognostic and Immunotherapeutic Marker of Pan-Cancer and Its Role in Anti-PD-1 Treatment of Bladder Cancer.

Introduction: Establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), a member of the EFO2 family, is implicated in the pathogenesis and progression of various cancers. However, there has been limited comprehensive pan-cancer analysis conducted on ESCO2 thus far.

Methods: Publicly available databases, such as the UCSC Xena database, were utilized to examine differential expression patterns across various cancer types.

Efficient Near-Infrared to Blue Photon Upconversion by Ultrafast Spin Flip and Triplet Energy Transfer at Organic/2D Semiconductor Interface.

Solid state photon upconversion by triplet-triplet annihilation (TTA), particularly near-infrared (NIR)-to-blue upconversion, holds instant promise for enhancing optoelectronic and photochemical applications. Despite extensive studies, NIR-to-blue upconversion has remained particularly challenging and elusive due to inherent multiple energy-downhill processes in TTA upconversion. In this study, using atomically thin two dimensional (2D) monolayer semiconductor as a triplet sensitizer, we demonstrate an efficient and robust solid-state NIR-to-blue photon upconversion system.

Distributed Identity Authentication with Lenstra-Lenstra-Lovász Algorithm-Ciphertext Policy Attribute-Based Encryption from Lattices: An Efficient Approach Based on Ring Learning with Errors Problem.

In recent years, research on attribute-based encryption (ABE) has expanded into the quantum domain. Because a traditional single authority can cause the potential single point of failure, an improved lattice-based quantum-resistant identity authentication and policy attribute encryption scheme is proposed, in which the generation of random values is optimized by adjusting parameters in the Gaussian sampling algorithm to improve overall performance. Additionally, in the key generation phase, attributes are processed according to their shared nature, which reduces the computational overhead of the authorization authority.

Surface Electromyography-Based Recognition of Electronic Taste Sensations.

Taste sensation recognition is a core for taste-related queries. Most prior research has been devoted to recognizing the basic taste sensations using the Brain-Computer Interface (BCI), which includes EEG, MEG, EMG, and fMRI. This research aims to recognize electronic taste (E-Taste) sensations based on surface electromyography (sEMG).

Migraine versus tension-type headache in automatic emotional processing: A visual mismatch negativity study.

Objective: It is important to discriminate different headaches in clinical practice, and neurocognitive biomarkers may serve as objective tools. Several reports have suggested potential cognitive impairment for primary headaches, whereas cognitions within specific domains remain elusive, e.g.

3D-Printed Stents Loaded with Saponin for Promoting Re-endothelialization and Reducing Local Inflammation in the Carotid Artery of Rabbits.

Endovascular treatment (EVT) using stents has become the primary option for severe cerebrovascular stenosis. However, considerable challenges remain to be addressed, such as in-stent restenosis (ISR) and late thrombosis. Many modified stents have been developed to inhibit the hyperproliferation of vascular smooth muscle cells (SMCs) and protect vascular endothelial cells (VECs), thereby reducing such complications.