An optimization model for monthly time-step drilling schedule under planned field production.

The field production profile over the yearly horizon is planned for a balance between economy, security, and sustainability of energy. An optimal drilling schedule is required to achieve the planned production profile with minimized drilling frequency and summation. In this study, we treat each possible production process of each well as a dependent time series and the basic unit.

A retrospective study on the management of massive hemoptysis by bronchial artery embolization: risk factors associated with recurrence of hemoptysis.

Background: Massive hemoptysis is a life-threatening condition that requires immediate treatment. This study aimed to retrospectively analyze the outcome of bronchial artery embolization (BAE) for massive hemoptysis, as well as potential factors that may contribute to the recurrence of hemoptysis after BAE.

Methods: A total of 105 patients with massive hemoptysis treated with BAE were analyzed.

Lonicera rupicola Hook.f.et Thoms flavonoids ameliorated dysregulated inflammatory responses, intestinal barrier, and gut microbiome in ulcerative colitis via PI3K/AKT pathway.

Background: Lonicera rupicola Hook.f.et Thoms (LRH) is used as a customary medicinal herb in Tibetans.

Regulating the Interfacial Electron Density of LaSrMnCoO/RuO for Efficient and Low-Cost Bifunctional Oxygen Electrocatalysts and Rechargeable Zn-Air Batteries.

LaSrMnCoO (LSMC) perovskite anchored with RuO (LSMC-Ru) is fabricated as a new bifunctional electrocatalyst, with low dosage (2.43 wt %) and high utilization of noble metal Ru. The LSMC-Ru exhibits outstanding bifunctional activity with a low potential gap of 0.

Cyclodextrin metal-organic framework as vaccine adjuvants enhances immune responses.

It is urgently needed to develop novel adjuvants for improving the safety and efficacy of vaccines. Metal-organic frameworks (MOFs), with high surface area, play an important role in drug delivery. With perfect biocompatibility and green preparation process, the γ-cyclodextrin metal-organic framework (γ-CD-MOF) fabricated with cyclodextrin and potassium suitable for antigen delivery.

Exploration of the Wound Healing Potential of Thermoplastic Polyurethane Electrospun Membrane Incorporated with Phenolic Acids in Spenceria ramalana Trimen.

Wound healing process is usually accompanied by infection and the wound dressing loaded with antibiotics is usually used to treat skin wound. However, the intensive use of antibiotics may lead to development of resistance and the antibiotic resistance has become a major global problem. Finding new wound dressing with sustained antibacterial property to overcome the problem of resistance is one of clinical challenge.

Electrospun Fibrous Membrane Containing a Cyclodextrin Covalent Organic Framework with Antibacterial Properties for Accelerating Wound Healing.

Skin wounds are usually accompanied by bacterial infections and inflammations, leading to delayed wound healing, which remain a great challenge in clinical treatment. Therefore, it is of great significance to develop wound dressings that inhibit bacterial infections to accelerate wound healing. Herein, we reported the fabrication of inclusion complex (a β-cyclodextrin covalent organic framework loaded with enrofloxacin and flunixin meglumine)-incorporated electrospun thermoplastic polyurethane fibers (named ENR-FM-COF-TPU) via electrospinning.

Reliability, Validity, and Measurement Invariance of the General Anxiety Disorder Scale Among Chinese Medical University Students.

Medical students are affected by high levels of general anxiety disorder. However, few studies have specifically focused on the applicability of universal anxiety screening tools in this sample. This study was aimed to evaluate the psychometric property of the 7-item Generalized Anxiety Disorder Scale (GAD-7) among Chinese medical university students.

Dual Energy Computed Tomography of Internal Carotid Artery: A Modified Dual-Energy Algorithm for Calcified Plaque Removal, Compared With Digital Subtraction Angiography.

Atherosclerotic disease of the internal carotid artery (ICA) is a common reason for ischemic stroke. Computed tomography angiography (CTA) is a common tool for evaluation of internal carotid artery (ICA) stenosis. However, blooming artifacts caused by calcified plaques might lead to overestimation of the stenosis grade.

Enrofloxacin/florfenicol loaded cyclodextrin metal-organic-framework for drug delivery and controlled release.

We presented an antibiotic-loaded γ-cyclodextrin metal-organic framework that delivered antibiotics suitable for the treatment of bacterial infections. The γ-cyclodextrin metal-organic framework was developed using γ-cyclodextrin and potassium ion via the ultrasonic method. The antibiotic (florfenicol and enrofloxacin) was primarily encapsulated into the pore structures of γ-CD-MOF, which allowed the sustained release of antibiotics over an extended period of time and .

Chinese medicine GeGen-DanShen extract protects from myocardial ischemic injury through promoting angiogenesis via up-regulation of VEGF/VEGFR2 signaling pathway.

Headings Ethnopharmacological Relevance: Coronary heart disease (CHD) usually refers to myocardial ischemia or myocardial necrosis caused by coronary artery stenosis. GeGen and DanShen (GD) are popular Chinese herbs for the treatment of angina pectoris and myocardial infarction (MI). This sentence needs to be a separate paragraph.

Anti-migraine effect of wine-processed Radix scutellariae: Pharmacodynamic verification in nitroglycerin-induced rats and correlation study between compounds dissolution and the fractal dimension.

Ethnopharmacological Relevance: Wine-processed Radix scutellariae (RS) is the processed product of RS, which is the dried root of Scutellaria baicalensis Georgi. It is recorded in Chinese traditional formula that wine-processed RS has the effect of anti-migraine, while the effect has not been confirmed and the possible mechanism remains unclear.

Aim Of The Study: To verify the anti-migraine effect of wine-processed RS in nitroglycerin (NTG)-induced rats and explore the correlation between compounds dissolution and the pore structure based on fractal theory.

Effect of liquiritin on neuroendocrine-immune network in menopausal rat model.

Purpose: The aim of the study was to investigate the effect of liquiritin on neuroendocrine-immune network in menopausal rat model.

Methods: Liquiritin groups were respectively given liquiritin suspension at the dose of 80, 40, and 20 mg/kg, once a day for continuous 30 days after the removal of bilateral ovaries to induce the menopausal rat model. Behavioral experiments were conducted and the organs were weighed for the viscera index.

Anti-rheumatoid arthritis effects of flavonoids from Daphne genkwa.

Objective: This study aims to select the most effective anti-Rheumatoid Arthritis (RA) component of flavonoids from Daphne genkwa Sieb. et Zucc. by anti-inflammatory and immunomodulatory effects in vitro, and to elucidate the mechanism.

In Vitro Anti-hepatitis B Virus Activity of 2',3'-Dideoxyguanosine.

2',3'-dideoxyguanosine (DoG) has been demonstrated to inhibit duck hepatitis B virus (DHBV) replication in vivo in a duck model of HBV infection. In the current study, the in vitro antiviral effects of DoG on human and animal hepadnaviruses were investigated. Our results showed that DoG effectively inhibited HBV, DHBV, and woodchuck hepatitis virus (WHV) replication in hepatocyte-derived cells in a dose-dependent manner, with 50% effective concentrations (EC) of 0.

Transport of curcumin derivatives in Caco-2 cell monolayers.

Curcumin (Cur) is a strong natural antioxidant, who can prevent multiple diseases such as anti-cancer, anti-inflammatory, have a resistance to alzheimer's disease and various malignant diseases. But it has poor oral bioavailability due to its poor aqueous solubility, as well as instability. While its novel derivatives (CB and FE), showed better anti-tumor activity, better anti-oxidant activity and better stability than the original drug (Cur).