The effects of COVID-19 lockdown and reopening on rest-activity rhythms in Singaporean working adults: A longitudinal age group comparison study.

Study Objectives: COVID-19 mobility restrictions disrupted daily rhythms worldwide, but how this rhythm disruption differs across age groups is unclear. We examined the course of age-related differences in trajectories of rest-activity rhythm during the COVID-19 pandemic lockdown and reopening in Singapore. We also evaluated the association of these patterns with mental well-being.

Brain activations elicited during task-switching generalize beyond the task: A partial least squares correlation approach to combine fMRI signals and cognition.

An underlying hypothesis for broad transfer from cognitive training is that the regional brain signals engaged during the training task are related to the transfer tasks. However, it is unclear whether the brain activations elicited from a specific cognitive task can generalize to performance of other tasks, esp. in normal aging where cognitive training holds much promise.

The Emerging Importance of Sleep Regularity on Cardiovascular Health and Cognitive Impairment in Older Adults: A Review of the Literature.

The regularity of sleep/wake patterns across multiple days is emerging as an important determinant of health. However, the association between sleep regularity and health outcomes in the aging population is not well understood. The current systematic review identified 22 publications that examined the relationship between sleep regularity and selected health outcomes: cardiovascular risk, cognitive impairment, and mortality.

The Effects of Computerized Cognitive Training in Older Adults' Cognitive Performance and Biomarkers of Structural Brain Aging.

Objectives: Cognitive training (CT) has been investigated as a means of delaying age-related cognitive decline in older adults. However, its impact on biomarkers of age-related structural brain atrophy has rarely been investigated, leading to a gap in our understanding of the linkage between improvements in cognition and brain plasticity. This study aimed to explore the impact of CT on cognitive performance and brain structure in older adults.

A three-dimensional network structure of metal-based nanozymes for the construction of colorimetric sensors for the detection of antioxidants.

Although many excellent nanozymes have been developed, designing and synthesizing highly active nanozymes is still challenging. Here, we developed a metal-based nanozyme (metal = Co, Fe, Cu, Zn) with a three-dimensional network structure. It possesses excellent peroxidase activity and catalyzes the reaction between HO and TMB to produce blue oxTMB, while antioxidants have different reducing power on the oxidation product of TMB (oxTMB), which leads to different absorbance and color changes.

Flower-like 3D MoS microsphere/2D CN nanosheet composite for highly sensitive electrochemical sensing of nitrite.

Nitrite pollution poses a serious threat to human health and the environment. In this study, a reliable and selective electrochemical (EC) sensor was developed for the quantitative determination of nitrite by combining flower-like three-dimensional (3D) MoS microspheres with two-dimensional (2D) CN nanosheets. Benefiting from the synergistic effects of MoS and CN, the 3D MoS/2D CN nanocomposite displayed numerous active sites, a 3D mesoporous structure, high conductivity and excellent catalytic activity.

An efficient single shot detector with weight-based feature fusion for small object detection.

Object detection has been widely applied in various fields with the rapid development of deep learning in recent years. However, detecting small objects is still a challenging task because of the limited information in features and the complex background. To further enhance the detection accuracy of small objects, this paper proposes an efficient single-shot detector with weight-based feature fusion (WFFA-SSD).

Colorimetric identification of multiple terpenoids based on bimetallic FeCu/NPCs nanozymes.

Nanozymes have been relatively well explored, and bimetal-doped nanozymes have attracted much exploration due to their superior catalytic activity. We developed bimetallic FeCu/NPCs and Cu/NPCs nanozymes, which have good catalytic properties due to the coordination of Fe and Cu with N and P. The nanozymes acted as sensing elements in a cascade reaction system to effectively recognize seven terpenoids, including menthol (Men), paeoniflorin (Pae), camphor (Cam), paclitaxel (Pac), andrographolide (Andro), ginkgolide A (Gin A), and piperone (Pip).

Co-exposure to particulate matter and humidity increases blood pressure in hypertensive mice via the TRPV4-cPLA-COX2 pathway.

Epidemiological studies have demonstrated that particulate matter (PM) can induce or exacerbate hypertension. High relative humidity has been associated with elevated blood pressure in certain regions. However, the coupling effect of humidity and PM on elevated blood pressure and the underlying mechanisms remain unknown.

Cognitive and structural predictors of novel task learning, and contextual predictors of time series of daily task performance during the learning period.

Investigation into methods of addressing cognitive loss exhibited later in life is of paramount importance to the field of cognitive aging. The field continues to make significant strides in designing efficacious cognitive interventions to mitigate cognitive decline, and the very act of learning a demanding task has been implicated as a potential mechanism of augmenting cognition in both the field of cognitive intervention and studies of cognitive reserve. The present study examines individual-level predictors of complex skill learning and day-to-day performance on a gamified working memory updating task, the BirdWatch Game, intended for use as a cognitive intervention tool in older adults.

Exploration of new therapeutic targets for viral hepatic fibrosis, alcoholic hepatic fibrosis, and non-alcoholic hepatic fibrosis.

Background: Hepatic fibrosis is a widespread disease worldwide. Millions of people lose their lives due to hepatic fibrosis every year. The main causes of hepatic fibrosis include viral infection, alcoholism, and obesity.

Targeted delivery via albumin corona nanocomplex to renal tubules to alleviate acute kidney injury.

Renal tubular epithelial cell (RTEC) is a critical target cell for the treatment of acute kidney injury (AKI). Despite various RTEC targeting strategies using ligand modified nanoparticles (NPs) following systemic administration, the nonspecific interaction between NPs and plasma proteins greatly weakens the targeting efficiency as well as the stability of NPs. Herein, celastrol (CLT) was entrapped in D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) forming a CLT-loaded nanocomplex core (CT) with a high loading capacity of ~50%.

The prognostic value of preoperative peripheral blood inflammatory indicators for squamous cell carcinoma of tongue.

Objectives: A study was conducted to investigate the value of preoperative peripheral blood inflammatory indicators in the prediction of tongue squamous cell carcinoma (TSCC) prognosis.

Methods: This retrospective analysis included 210 patients who underwent radical resection for TSCC in the Department of Oral and Maxillofacial Surgery of The First Affiliated Hospital of Zhengzhou University from January 2010 to December 2017. Receiver operating characteristic curve was conducted to determine the best cut-off values of platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR).

Fitness and arterial stiffness in healthy aging: Modifiable cardiovascular risk factors contribute to altered default mode network patterns during executive function.

Increases in cardiovascular risks such as high blood pressure and low physical fitness have been independently associated with altered default mode network (DMN) activation patterns in healthy aging. However, cardiovascular risk is a multidimensional health problem. Therefore, we need to investigate multiple cardiovascular risk factors and their contributions to cognition and DMN activations in older adults, which has not yet been done.

Mobility in China, 2020: a tale of four phases.

2020 was an unprecedented year, with rapid and drastic changes in human mobility due to the COVID-19 pandemic. To understand the variation in commuting patterns among the Chinese population across stable and unstable periods, we used nationwide mobility data from 318 million mobile phone users in China to examine the extreme fluctuations of population movements in 2020, ranging from the Lunar New Year travel season (), to the exceptional calm of COVID-19 lockdown, and then to the recovery period. We observed that cross-city movements, which increased substantially in and then dropped sharply during the lockdown, are primarily dependent on travel distance and the socio-economic development of cities.

Mobile Phone-Based Population Flow Data for the COVID-19 Outbreak in Mainland China.

Background: Human migration is one of the driving forces for amplifying localized infectious disease outbreaks into widespread epidemics. During the outbreak of COVID-19 in China, the travels of the population from Wuhan have furthered the spread of the virus as the period coincided with the world's largest population movement to celebrate the Chinese New Year.

Methods: We have collected and made public an anonymous and aggregated mobility dataset extracted from mobile phones at the national level, describing the outflows of population travel from Wuhan.

Comparing the Effects of Two Cardiovascular Health Factors on Working Memory Capacity in Healthy Aging: Separate and Combined Effects of Arterial Elasticity and Physical Fitness.

Objectives: Arterial elasticity and physical fitness are 2 important cardiovascular health factors that influence cognition in older adults. Working memory capacity (WMC), a core component underlying cognitive aging across many cognitive domains, may be affected by individual differences in cardiovascular health in older adults. This study aims to identify in older adults: (a) separate and combined effects of these 2 cardiovascular health factors on WMC and (b) which of the 2 factors is more critical in influencing WMC.

[Clinical value of oral repair membrane and β-tricalcium phosphate in the treatment of the postoperative bone defect of jaw cyst].

Objective: This study aims to evaluate the clinical effect of oral repair membrane and β-tricalcium phosphate (β-TCP) on the treatment of jaw cyst.

Methods: A retrospective analysis was performed on 81 cases of jaw cysts, and clinical data were collected for the comparison of traditional surgical curettage (group A, 27 cases), biofilm covering bone wounds after curettage (group B, 27 cases), and β-TCP filling combined with biofilm covering.

Results: No recurrence occurred in 81 patients, and no significant difference in preoperative CT value among the three groups (P<0.

Depressive Emotion Detection and Behavior Analysis of Men Who Have Sex With Men Social Media.

Background: A large amount of evidence has indicated an association between depression and HIV risk among men who have sex with men (MSM), but traditional questionnaire-based methods are limited in timely monitoring depressive emotions with large sample sizes. With the development of social media and machine learning techniques, MSM depression can be well monitored in an online and easy-to-use manner. Thereby, we adopt a machine learning algorithm for MSM depressive emotion detection and behavior analysis with online social networking data.