Integrating Two Photochromics into One Three-Dimensional Covalent Organic Framework for Synergistically Enhancing Multiple Photocatalytic Oxidations.

While photocatalytic oxidations are a category of important reactions in wide chemical synthesis, the fabrication of effective photocatalysts for broad oxidation reactions is still of a great challenge. Herein, by rationally integrating two photochromics, porphyrin and triphenylamine, a three-dimensional photoactive covalent organic framework (COF) is successfully constructed for photocatalytic oxidations. Characterization studies not only show the formation of a crystalline and three-dimensional porous framework, but also reveal its effective photochemical semiconductor properties derived from the porphyrin and triphenylamine moieties.

Elevated Astrocytic NFAT5 of the hippocampus increases epilepsy susceptibility in hypoxic-ischemic mice.

Objective: Hypoxic-ischemic brain damage (HIBD) is a leading cause of neonatal mortality, resulting in brain injury and persistent seizures that can last into the late neonatal period and beyond. Effective treatments and interventions for infants affected by hypoxia-ischemia remain lacking. Clinical investigations have indicated an elevation of nuclear factor of activated T cells 5 (NFAT5) in whole blood from umbilical cords of severely affected HIBD infants with epilepsy.

Cost-effective gaze tracking system based on polymer fiber specklegrams.

Gaze tracking technology has a wide range of applications in the fields of VR/AR glasses. In this paper, a plastic optical fiber (POF) is used as a light transmission waveguide to transmit the light reflected from the eye to the outside of the device for processing, thereby eliminating the need for in-device camera installations. By processing two fan-shaped surfaces on the POF at a 45° angle relative to the vertical direction, the POF gains the ability to couple light from the side.

Impact of Health Education in Combination with Nutrition Support Nursing on the Nutritional Status and Quality of Life in Patients with Pulmonary Tuberculosis.

This study aimed to ascertain the effects of health education combined with nutrition support nursing on the nutritional status and quality of life of patients with pulmonary tuberculosis. A clinical study was conducted. Sixty-four patients with tuberculosis were selected as the study participants and divided into control and observation groups ( = 32).

Judicial improvement, market integration, and export technical complexity-a quasi-natural experiments based on the creation of circuit courts.

Judicial improvement and trade structure optimization are important elements in achieving a high level of openness. This paper develops a theoretical framework on the impact of local protectionism on market integration and export technical complexity, and then empirically analyses the effect of judicial improvement on the technical complexity of urban product exports and its mechanism of action based on a quasi-natural experiment with the establishment of circuit courts. The study finds that the establishment of circuit courts significantly increases the technical complexity of product exports, and the findings remain valid after a series of robustness tests.

Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity.

Background: The astrocytes in the central nervous system (CNS) exhibit morphological and functional diversity in brain region-specific pattern. Functional alterations of reactive astrocytes are commonly present in human temporal lobe epilepsy (TLE) cases, meanwhile the neuroinflammation mediated by reactive astrocytes may advance the development of hippocampal epilepsy in animal models. Nuclear factor I-A (NFIA) may regulate astrocyte diversity in the adult brain.

Anchoring Polar Organic Molecules in Defective Ammonium Vanadate for High-Performance Flexible Aqueous Zinc-Ion Battery.

Ammonium vanadate (NVO) often has unsatisfactory electrochemical performance due to the irreversible removal of NH during the reaction. Herein, layered DMF-NVO nanoflake arrays (NFAs) grown on highly conductive carbon cloth (CC) are employed as the binder-free cathode (DMF-NVO NFAs/CC), which produces an enlarged interlayer spacing of 12.6 Å (against 9.

In Situ Construction of Heterostructured CoO/CoP Nanoflake Arrays on Carbon Cloth as Binder-Free Anode for High-Performance Lithium-Ion Batteries.

Cobalt oxide (CoO) is regarded as the anode material for lithium-ion batteries (LIBs) with great research value owing to its environmental friendliness and exceptional theoretical capacity. However, the low intrinsic conductivity, poor electrochemical kinetics, and unsatisfactory cycling performance severely limit its practical applications in LIBs. The construction of a self-standing electrode with heterostructure by introducing a highly conductive cobalt-based compound is an effective strategy to solve the above issues.

Transient Receptor Potential Vanilloid 4: a Double-Edged Sword in the Central Nervous System.

Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel that can be activated by diverse stimuli, such as heat, mechanical force, hypo-osmolarity, and arachidonic acid metabolites. TRPV4 is widely expressed in the central nervous system (CNS) and participates in many significant physiological processes. However, accumulative evidence has suggested that deficiency, abnormal expression or distribution, and overactivation of TRPV4 are involved in pathological processes of multiple neurological diseases.

Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) Mitigates Seizures.

Astrocytes are critical regulators of the immune/inflammatory response in several human central nervous system (CNS) diseases. Emerging evidence suggests that dysfunctional astrocytes are crucial players in seizures. The objective of this study was to investigate the role of transient receptor potential vanilloid 4 (TRPV4) in 4-aminopyridine (4-AP)-induced seizures and the underlying mechanism.

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1.

Epilepsy is a brain condition characterized by the recurrence of unprovoked seizures. Recent studies have shown that complement component 3 (C3) aggravate the neuronal injury in epilepsy. And our previous studies revealed that TRPV1 (transient receptor potential vanilloid type 1) is involved in epilepsy.

Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy.

Epilepsy is a common brain disorder, repeated seizures of epilepsy may lead to a series of brain pathological changes such as neuronal or glial damage. However, whether circular RNAs are involved in neuronal injury during epilepsy is not fully understood. Here, we screened circIgf1r in the status epilepticus model through circRNA sequencing, and found that it was upregulated after the status epilepticus model through QPCR analysis.

TRPV1 translocated to astrocytic membrane to promote migration and inflammatory infiltration thus promotes epilepsy after hypoxic ischemia in immature brain.

Background: Neonatal hypoxic-ischemic brain damage (HIBD), a leading cause of neonatal mortality, has intractable sequela such as epilepsy that seriously affected the life quality of HIBD survivors. We have previously shown that ion channel dysfunction in the central nervous system played an important role in the process of HIBD-induced epilepsy. Therefore, we continued to validate the underlying mechanisms of TRPV1 as a potential target for epilepsy.