Relationship between social support and depressive symptoms among internal migrant workers and the mediating role of healthy lifestyle: a cross-sectional study in China.

Objectives: To investigate the association between social support and depressive symptoms among internal migrant workers with a focus on the mediating role of a healthy lifestyle.

Design: Cross-sectional study.

Setting: The research was conducted among internal migrant workers in Henan Province, China, in August 2023.

The crop mined phosphorus nutrition via modifying root traits and rhizosphere micro-food web to meet the increased growth demand under elevated CO.

Elevated CO (eCO) stimulates productivity and nutrient demand of crops. Thus, comprehensively understanding the crop phosphorus (P) acquisition strategy is critical for sustaining agriculture to combat climate changes. Here, wheat ( L) was planted in field in the eCO (550 µmol mol) and ambient CO (aCO, 415 µmol mol) environments.

Integrative study of lung cancer adeno-to-squamous transition in EGFR TKI resistance identifies RAPGEF3 as a therapeutic target.

Although adeno-to-squamous transition (AST) has been observed in association with resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) in clinic, its causality, molecular mechanism and overcoming strategies remain largely unclear. We here demonstrate that squamous transition occurs concomitantly with TKI resistance in PC9-derived xenograft tumors. Perturbation of squamous transition via DNp63 overexpression or knockdown leads to significant changes in TKI responses, indicative of a direct causal link between squamous transition and TKI resistance.

Isobicyclogermacrenal ameliorates hippocampal ferroptosis involvement in neurochemical disruptions and neuroinflammation induced by sleep deprivation in rats.

Background: Sleep deprivation (SLD) is a widespread condition that disrupts physiological functions and may increase mortality risk. Valeriana officinalis, a traditional medicinal herb known for its sedative and hypnotic properties, contains isobicyclogermacrenal (IG), a newly isolated active compound. However, research on the therapeutic potential of IG for treating SLD remains limited.

Discovery and characterization of potent broadly neutralizing antibodies from human survivors of severe fever with thrombocytopenia syndrome.

Background: Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne phlebovirus that causes viral hemorrhagic fever. Pandemic concerns have arisen due to the increased human-to-human transmission and high mortality rate, highlighting the urgent need for specific therapeutics.

Methods: Our observational study characterized the memory B cell response to natural SFTSV infection in four survivors.

Multi-hop interpretable meta learning for few-shot temporal knowledge graph completion.

Multi-hop path completion is a key part of temporal knowledge graph completion, which aims to infer complex relationships and obtain interpretable completion results. However, the traditional multi-hop path completion models mainly focus on the static knowledge graph with sufficient relationship instances, and does not consider the impact of timestamp information on the completion path, and is not suitable for few-shot relations. These limitations make the performance of these models not good when dealing with few-shot relationships in temporal knowledge graphs.

Structural insights into endogenous ligand selectivity and activation mechanisms of FFAR1 and FFAR2.

Free fatty acid receptors (FFARs) play critical roles in metabolic regulation and are potential therapeutic targets for metabolic and inflammatory diseases. A comprehensive understanding of the activation mechanisms and endogenous ligand selectivity of FFARs is essential for drug discovery. Here, we report two cryoelectron microscopy structures of the human FFAR1 bound to the endogenous ligand docosahexaenoic acid (DHA) and G protein as well as FFAR2 in complex with butyrate and G at 3.

Host specific sphingomyelin is critical for replication of diverse RNA viruses.

Lipids and lipid metabolism play an important role in RNA virus replication, which typically occurs on host cell endomembrane structures in the cytoplasm through mechanisms that are not yet fully identified. We conducted genome-scale CRISPR screening and identified sphingomyelin synthase 1 (SMS1; encoded by SGMS1) as a critical host factor for infection by severe fever with thrombocytopenia syndrome virus (SFTSV). SGMS1 knockout reduced sphingomyelin (SM) (d18:1/16:1) levels, inhibiting SFTSV replication.

Comprehensive analysis of Capsicum annuum CaLhcs uncovered the roles of CaLhca5.1 and CaLhcb1.7 in photosynthesis and stress tolerance.

The light-harvesting chlorophyll a/b-binding proteins (Lhcs) are integral to plants' capture and transfer of light energy during photosynthesis. However, the Lhc gene family remains unexplored in pepper. In this study, 37 CaLhcs (Capsicum annuum Lhc) were identified from the reference genome and classified into five subfamilies (Lhca, Lhcb, CP24, CP26, and CP29) based on phylogenetic relationships and conserved domains, with members of each subfamily displaying similar conserved motifs and gene structures.

Physics-informed Score-based Diffusion Model for Limited-angle Reconstruction of Cardiac Computed Tomography.

Cardiac computed tomography (CT) has emerged as a major imaging modality for the diagnosis and monitoring of cardiovascular diseases. High temporal resolution is essential to ensure diagnostic accuracy. Limited-angle data acquisition can reduce scan time and improve temporal resolution, but typically leads to severe image degradation and motivates for improved reconstruction techniques.

High-Quality Image Compression Algorithm Design Based on Unsupervised Learning.

Increasingly massive image data is restricted by conditions such as information transmission and reconstruction, and it is increasingly difficult to meet the requirements of speed and integrity in the information age. To solve the urgent problems faced by massive image data in information transmission, this paper proposes a high-quality image compression algorithm based on unsupervised learning. Among them, a content-weighted autoencoder network is proposed to achieve image compression coding on the basis of a smaller bit rate to solve the entropy rate optimization problem.

Bee venom prompts the inhibition of gefitinib on proliferation, migration, and invasion of non-small cell lung cancer cells via EGFR-mediated autophagy.

It has been confirmed that bee venom (BV) can inhibit tumor metastasis of lung cancer cells induced by epidermal growth factor, suggesting the inhibitory role of BV on the regulation of epidermal growth factor receptor (EGFR), and may synergistically promote the anti-lung cancer effect of EGFR tyrosine kinase inhibitor gefitinib. This paper aims to ascertain the therapeutic potentials of BV combined with gefitinib against non-small cell lung cancer (NSCLC) in vitro. As results, the content of the main component melittin in air-dried BV was determined by HPLC.

DyGraphformer: Transformer combining dynamic spatio-temporal graph network for multivariate time series forecasting.

Transformer-based models demonstrate tremendous potential for Multivariate Time Series (MTS) forecasting due to their ability to capture long-term temporal dependencies by using the self-attention mechanism. However, effectively modeling the spatial correlation cross series for MTS is a challenge for Transformer. Although Graph Neural Networks (GNN) are competent for modeling spatial dependencies across series, existing methods are based on the assumption of static relationships between variables, which do not align with the time-varying spatial dependencies in real-world series.

Microplastics colonized by Hafnia paralvei through biofilm formation regulated by c-di-GMP and cAMP promote its spread in water.

Microplastics (MPs) colonized by pathogens pose significant risks to the environment and health of animals and humans, however, the strategies for pathogens colonization in MPs and the effects of its colonization on spread of pathogens have not been fully characterized. Here, we investigated the biofilm formation mechanism regulated by c-di-GMP in Hafnia paralvei Z11, and determined the effect of MPs colonized by H. paralvei Z11 on the spread of strain Z11.

Mercaptopropionic acid-capped CdZnTe Quantum dots as Fluorescence Probe for Sensitive Detection of Cr(III) ions.

Although Cr(III) ions are essential for the human body, excessive amounts can lead to skin inflammation, allergic reactions, and genotoxicity. A highly sensitive fluorescence probe was developed using mercaptopropionic acid (MPA) capped CdZnTe quantum dots (QDs) synthesized via an aqueous solution heating method for precise detection of Cr(III) ions. The synthesized MPA-CdZnTe QDs had a size of 2.

The Pattern and Staging of Brain Atrophy in Spinocerebellar Ataxia Type 2 (SCA2): MRI Volumetrics from ENIGMA-Ataxia.

Objective: Spinocerebellar ataxia type 2 (SCA2) is a rare, inherited neurodegenerative disease characterised by progressive deterioration in both motor coordination and cognitive function. Atrophy of the cerebellum, brainstem, and spinal cord are core features of SCA2, however the evolution and pattern of whole-brain atrophy in SCA2 remain unclear. We undertook a multi-site, structural magnetic resonance imaging (MRI) study to comprehensively characterize the neurodegeneration profile of SCA2.

LoMAE: Simple Streamlined Low-Level Masked Autoencoders for Robust, Generalized, and Interpretable Low-Dose CT Denoising.

Low-dose computed tomography (LDCT) offers reduced X-ray radiation exposure but at the cost of compromised image quality, characterized by increased noise and artifacts. Recently, transformer models emerged as a promising avenue to enhance LDCT image quality. However, the success of such models relies on a large amount of paired noisy and clean images, which are often scarce in clinical settings.

Mapping subcellular RNA localization with proximity labeling.

The subcellular localization of RNA is critical to a variety of physiological and pathological processes. Dissecting the spatiotemporal regulation of the transcriptome is key to understanding cell function and fate. However, it remains challenging to effectively enrich and catalogue RNAs from various subcellular structures using traditional approaches.

Simultaneous Single-Position Oblique Lumbar Interbody Fusion and Percutaneous Pedicle Screw Fixation under O-Arm Navigation for Modified MISDEF Type II Adult Degenerative Scoliosis: Case Series and Surgical Technique.

Purpose: Oblique lumbar interbody fusion (OLIF) has become a popular technique for treating adult degenerative scoliosis (ADS), but traditional OLIF technology often requires repositioning for one-stage or staged posterior fixation. The objective of this pilot study was to describe the surgical technique of simultaneous single-position OLIF and percutaneous pedicle screw fixation (OLIF 360) under O-Arm navigation for modified MISDEF type II ADS.

Methods: Between June 2022 and December 2023, six patients classified as having modified MISDEF type II ADS underwent OLIF 360 assisted by O-Arm navigation at our institution.

Wheat lesion mimic homology gene TaCAT2 enhances plant resistance to biotic and abiotic stresses.

Lesion mimic mutants (LMMs) refer to the spontaneous formation of disease-like spots on leaves without any obvious pathogen infection. The LMM genes can regulate plant immunity, thus promoting the defense of crops against pathogens. However, there is a lack of systematic understanding of the regulatory mechanism of LMMs in wheat.

Metabolomic Applications in Gut Microbiota-Host Interactions in Human Diseases.

The human gut microbiota, consisting of trillions of microorganisms, encodes diverse metabolic pathways that impact numerous aspects of host physiology. One key way in which gut bacteria interact with the host is through the production of small metabolites. Several of these microbiota-dependent metabolites, such as short-chain fatty acids, have been shown to modulate host diseases.