An all integer-based spiking neural network with dynamic threshold adaptation.

Spiking Neural Networks (SNNs) are typically regards as the third generation of neural networks due to their inherent event-driven computing capabilities and remarkable energy efficiency. However, training an SNN that possesses fast inference speed and comparable accuracy to modern artificial neural networks (ANNs) remains a considerable challenge. In this article, a sophisticated SNN modeling algorithm incorporating a novel dynamic threshold adaptation mechanism is proposed.

Morphological and clinical study of lateral malleolus fractures based on fracture mapping: a retrospective study.

Background: The traditional classification for lateral malleolus fracture has its limitations. In this study, we introduced a three-dimensional (3D) fracture mapping technique using computed tomography (CT) data to assess fracture line distributions and their impact on patient outcomes, offering a refined classification approach.

Methods: Retrospectively, we analysed 97 patients who underwent lateral malleolus fracture surgeries (2014-2019), using CT Digital Imaging and Communications in Medicine data to create 3D models and fracture maps.

Cross sectional associations of physical activity and sleep with mental health among Chinese university students.

Objective: This study aimed to examine the levels of physical activity (PA), sleep, and mental health (MH), specifically depression, anxiety, and stress, among Chinese university students. It also aimed to analyze the influencing factors of MH, providing a theoretical foundation for developing intervention programs to improve college students' mental health.

Methods: A stratified, clustered, and phased sampling method was employed.

Alleviating batch effects in cell type deconvolution with SCCAF-D.

Cell type deconvolution methods can impute cell proportions from bulk transcriptomics data, revealing changes in disease progression or organ development. But benchmarking studies often use simulated bulk data from the same source as the reference, which limits its application scenarios. This study examines batch effects in deconvolution and introduces SCCAF-D, a computational workflow that ensures a Pearson Correlation Coefficient above 0.

SOX2-induced IL1α-mediated immune suppression drives epithelial dysplasia malignant transformation.

Squamous cell carcinomas (SCC) are often preceded by potentially malignant precursor lesions, most of which remain benign. The terminal exhaustion phenotypes of effector T-cells and the accumulation of myeloid-derived suppressor cells (MDSC) have been thoroughly characterized in established SCC. However, it is unclear what precancerous lesions harbor a bona fide high risk for malignant transformation and how precancerous epithelial dysplasia drives the immune system to the point of no return.

The effect of micro-movement on prevention of intraoperative acquired pressure injury in overweight patients undergoing posterior lumbar surgery: a randomized controlled trial.

Background: In posterior lumbar surgery, overweight patients are more prone to intraoperative acquired pressure injury (IAPI) due to bleeding, longer operative time, and increased pressure. The current prevention strategies have limited effects.

Methods: This was a single-blind, prospective, randomized controlled trial conducted from April 2023 to September 2024.

Mapping and cloning of pepper fruit color-related genes based on BSA-seq technology.

Fruit color is an important qualitative trait that greatly influences the marketability of peppers. Fruit color can be divided into two categories. Green fruit color denotes commercial maturity, whereas ripe fruit indicates physiological maturity.

Fiber-based biomaterial scaffolds for cell support towards the production of cultivated meat.

The in vitro production of animal-derived foods via cellular agriculture is emerging as a key solution to global food security challenges. Here, the potential for fiber-based scaffolds, including silk and cotton, in the cultivation of muscle cells for tissue formation was pursued. Mechanical properties and cytocompatibility with the mouse myoblast cell line C2C12 and immortalized bovine muscle satellite cells (iBSCs) were assessed, as well as pre-digestion options for the materials due to their resilience within the human digestive track.

Prevalence, clinical characteristics and outcomes of seizures in neurofibromatosis type 1: A systematic review and single arm meta-analysis.

Background: Neurofibromatosis type 1 (NF1) is a common neurocutaneous syndrome that predisposes patients to seizures. We aimed to estimate the prevalence, clinical characteristics and outcomes of seizures in NF1 patients, and analyze prognostic factors of seizures.

Methods: Systematic searches were conducted in the PubMed, EMBASE, Web of Science, Scopus, Cochrane Library, and grey literature databases from inception to April 2024.

Cold Atmospheric Plasma: Possible Cure of Autoimmune Disorders and Cancer via Attenuating Inflammation.

Autoimmune diseases and cancers, two seemingly unrelated diseases, have been threatening human health, and many of them have no cure. By identifying pathological inflammation as the driving cause of uncontrolled cell proliferation in both classes of diseases, and differentiating autoimmune disorders and cancers by whether the cell death programs are under control, we propose the attenuation of prolonged inflammation via maintaining mitochondrial reduction-oxidation (redox) homeostasis being a possible cure of both diseases. Importantly, we propose the feasibility of applying cold atmospheric plasma (CAP) in treating autoimmune disorders and cancers given its redox-modulatory nature, which not only extends the medical utilities of CAP to autoimmune diseases and all other inflammation-driven disorders, but also positions the efficacy of CAP against cancer cells to its suppressive role on prolonged inflammation.

Experimental study on the compression and shear deformation evolution of coal pillar dam samples.

To understand the mechanical properties and deformation failure patterns of coal pillar dams in gently inclined coal seam mine underground reservoirs, compression-shear coupling tests with variable angles were conducted on coal pillar dam samples under different saturation states. The digital image correlation (DIC) technique was utilized to obtain the deformation patterns of the displacement field throughout the compression-shear failure process of the samples. Numerical simulations were used to perform a comparative analysis and validation of the experimental results.

Therapeutic potential of plasma-treated solutions in atopic dermatitis.

Atopic Dermatitis (AD) is a prevalent inflammatory skin disease that is currently incurable. Plasma-treated solutions (PTS) (e.g.

Integration of 3D printing and case-based learning in clinical practice for the treatment of developmental dysplasia of the hip.

Background: Case-based learning (CBL) utilizing three-dimensional (3D) printed hip joint models is a problem-solving teaching method that combines the tactile and visual advantages of 3D-printed models with CBL. This study aims to investigate the impact of integrating 3D printing with CBL on learning developmental dysplasia of the hip (DDH).

Methods: We conducted a prospective study from 2022 to 2023, including 120 fourth-year clinical medical students at Xuzhou Medical University.

Using Structural Equation Modelling to Explore the Relationship Between Patient-Centered Communication, Human Papilloma (HPV)-related Knowledge, and Perceived Effectiveness of the HPV Vaccine.

Background: Patient-centered communication has emerged as a potent strategy for increasing vaccine uptake. Drawing on evidence-based paths established from previous studies, our study examines the relationship between patient-centered communication, HPV knowledge and perceived HPV vaccine effectiveness. We also explored the sociodemographic factors impacting patient-centered communication, HPV knowledge and perceived HPV vaccine effectiveness.

Epicardial adipose tissue volume and density are associated with heart failure with improved ejection fraction.

Background: Heart failure (HF) with improved ejection fraction (EF, HFimpEF) is a distinct HF subtype, characterized by left ventricular (LV) reverse remodeling and myocardial functional recovery. Multiple cardiometabolic factors are implicated in this process. Epicardial adipose tissue (EAT), emerging as an endocrine and paracrine organ, contributes to the onset and progression of HF.

Hemagglutination Inhibition Antibody Titers as Mediators of Influenza Vaccine Efficacy Against Symptomatic Influenza A(H1N1), A(H3N2), and B/Victoria Virus Infections.

Background: The hemagglutination inhibition antibody (HAI) titer contributes only a part of vaccine-induced protection against influenza virus infections. Using causal mediation analysis, we quantified the proportion of vaccine efficacy mediated by postvaccination HAI titers.

Methods: We conducted causal mediation analyses using data from a randomized, active-comparator controlled, phase III, trial of an inactivated, split-virion seasonal quadrivalent influenza vaccine in children conducted from October 2010 to December 2011 in 8 countries.