USP9X PROMOTES LPS-INDUCED FIBROBLAST CELL APOPTOSIS, INFLAMMATION, AND OXIDATIVE STRESS BY REGULATION OF TBL1XR1 DEUBIQUITINATION.

Background: Ubiquitination and deubiquitination are involved in the progression of human diseases, including acute pneumonia. In this study, we aimed to explore the functions of ubiquitin-specific peptidase 9X-linked (USP9X) in lipopolysaccharide (LPS)-treated WI-38 cells. Methods: WI-38 cells were treated with LPS to induce the cellular damage and inflammation.

Blue food proteins: Novel extraction technologies, properties, bioactivities and applications in foods.

With the growing demand for healthy and sustainable food, blue food proteins have emerged as an important way to address resource-intensive production and environmental concerns. This paper systematically reviewed the extraction technologies, properties and bioactivities of blue food proteins and explored their wide range of applications. The novel extraction technologies not only improve the extraction efficiency of the proteins, shorten the production time and have environmental advantages, but also enhance the protein properties and facilitate subsequent applications.

Effects of flotation reagents with aniline aerofloat and ammonium dibutyl dithiophosphate on a constructed rapid infiltration system: Performance and microbial metabolic pathways.

Aniline aerofloat (AAF) and ammonium dibutyl dithiophosphate (ADD) are the key flotation reagents in mineral processing. This study investigated the performance of the constructed rapid infiltration systems with coke and red mud as adsorbents for treatment AAF and ADD wastewater. Meanwhile, the effects of AAF and ADD on the microbial metabolic pathways of the systems were unraveled.

Multiple roles of food-derived bioactive peptides in the management of T2DM and commercial solutions: A review.

Type 2 diabetes mellitus (T2DM), a disease that threatens public health worldwide and can cause a series of irreversible complications, has been a major concern. Although the treatment based on hypoglycemic drugs is effective, its side effects should not be ignored, which has led to an urgent need for developing new hypoglycemic drugs. Bioactive peptides with antidiabetic effects obtained from food proteins have become a research hotspot as they are safer and with higher specificity than traditional hypoglycemic drugs.

Surface Defect Detection of Aluminum Profiles Based on Multiscale and Self-Attention Mechanisms.

To address the various challenges in aluminum surface defect detection, such as multiscale intricacies, sensitivity to lighting variations, occlusion, and noise, this study proposes the AluDef-ClassNet model. Firstly, a Gaussian difference pyramid is utilized to capture multiscale image features. Secondly, a self-attention mechanism is introduced to enhance feature representation.

First-line immunotherapy efficacy in advanced squamous non-small cell lung cancer with PD-L1 expression ≥50%: a network meta-analysis of randomized controlled trials.

Objective: The optimal first-line immunotherapy regimen for patients with PD-L1 expression ≥50% in squamous non-small cell lung cancer (Sq-NSCLC) remains uncertain. This study utilized net-work meta-analysis (NMA) to indirectly compare the efficacy of various first-line immuno-therapy regimens in this patient subset.

Methods: Systematic searches were conducted across PubMed, the Cochrane Library, Web of Science, and Embase databases for randomized controlled trials reporting overall survival (OS) and progression-free survival (PFS) outcomes.

A novel phosphorus-nitrogen-based hyperbranched polysiloxane for improving the fire safety of PA6 with suppressed melt droplets and good mechanical properties.

The combustible defects of polyamide 6 (PA6), especially the flammable melt-dripping behavior, have greatly limited its application in some particular fields. In this work, a halogen-free hyperbranched polysiloxane (PBDSi) containing DOPO and Schiff base was designed via Michael's addition reaction and dehydration-condensation reaction. Results showed that the char yield () of PBDSi attained 37.

Research on the Health Assessment Method of the Safety Retaining Wall in a Dump Based on UAV Point-Cloud Data.

The safety retaining wall is a critical infrastructure in ensuring the safety of both rock removal vehicles and personnel. However, factors such as precipitation infiltration, tire impact from rock removal vehicles, and rolling rocks can cause local damage to the safety retaining wall of the dump, rendering it ineffective in preventing rock removal vehicles from rolling down and posing a huge safety hazard. To address these issues, this study proposed a safety retaining wall health assessment method based on modeling and analysis of UAV point-cloud data of the safety retaining wall of a dump, which enables hazard warning for the safety retaining wall.

Effects of perfluoroalkyl substances on the operational efficiency, microbial communities, and key metabolic pathways of constructed rapid infiltration system with coke as filler layer.

Influences of perfluoroalkyl substances on the performance and microbial metabolic pathways of constructed rapid infiltration systems are not fully understood. In this study, wastewater containing different concentrations of perfluorooctanoic acid (PFOA)/perfluorobutyric acid (PFBA) was treated in constructed rapid infiltration systems with coke as filler. The addition of 5 and 10 mg/L PFOA inhibited the removal of chemical oxygen demand (COD) (80.

Silicon/nitrogen synergistically reinforced flame-retardant PA6 nanocomposites with simultaneously improved anti-dripping and mechanical properties.

A facile route of 'copolymerization/blending' was proposed to fabricate silicon/nitrogen synergistically reinforced flame-retardant PA6 nanocomposites with simultaneously improved anti-dripping and mechanical properties. Firstly, a persistently inherent flame-retardant PA6 (FR-PA6), with 1,3-bis(3-aminopropyl)tetramethyl disiloxane (MSDS), was synthesized controllable amidation and a polycondensation reaction. Melamine cyanurate (MCA) nanoparticles as a 'gas phase' synergistic agent were then added into FR-PA6 to further improve its flame retardancy.

Phylogenetic diversity of Archaea in the intestinal tract of termites from different lineages.

Termites are among the few arthropods that emit methane to the atmosphere, which is a significant source of global greenhouse gas due to their huge biomass on earth. In this study, phylogenetic diversity of Archaea of five termite species from different lineages were analyzed based on 16S rRNA genes. Archaea associated with wood-feeding lower termite, R.

[Detection of polA gene in whole blood samples and preliminary observations with molecular subtyping of Treponema pallidum].

Objective: To detect Treponema pallidum (T.pallidum) DNA with polymerase chain reaction (PCR) in whole blood samples of syphilis patients and analyze their features of sub-genotypes.

Methods: The clinical data of patients were collected from July 2012 to February 2013.