Publications by authors named "Shunya Yokota"
Objective: We identified the associated factors and compared the survival times of feline hyperthyroidism (FHT) between thyroidectomy and methimazole alone.
Methods: The medical records of 41 cats diagnosed with new-onset hyperthyroidism were retrospectively reviewed. The cats were categorized into the thyroidectomy (n = 15) and methimazole (26) treatment groups.
Objective: Comparing the utility of the anti-human serum amyloid A (SAA)-specific monoclonal and polyclonal antibodies assays (LZ-SAA) with the pure monoclonal anti-human antibody assays (VET-SAA) during clinical practice in primary care hospital populations by measuring SAA measurement in healthy and diseased domestic cats.
Animals: 52 healthy and 185 diseased client-owned cats.
Methods: SAA concentration was measured using different LZ-SAA and VET-SAA measurements for healthy and various diseased cats.
Article Synopsis
- An 11-year-old neutered male Jack Russell Terrier was diagnosed with immune-mediated hemolytic anemia (IMHA) after presenting with regenerative anemia while being treated for hypoadrenocorticism.
- Despite treatment with prednisolone and mycophenolate mofetil, the dog's condition worsened to nonregenerative anemia, prompting a bone marrow examination.
- The bone marrow showed severe erythroid hypoplasia, leading to a diagnosis of pure red cell aplasia (PRCA), and ultimately the dog died from thrombosis, marking a unique case of PRCA following IMHA during hypoadrenocorticism treatment.
Article Synopsis
- Precursor-targeted immune-mediated anemia (PIMA) is a condition in dogs characterized by nonregenerative anemia, thought to result from the immune system attacking erythroid precursors, though this is not definitively proven.* -
- Treatment usually involves glucocorticoids, but when these are ineffective, other immunosuppressants are added; however, some cases do not go into remission.* -
- In two cases of severe PIMA, a combination of traditional immunosuppressants and the Janus kinase-1 inhibitor oclacitinib led to improvement and complete remission, suggesting oclacitinib as a viable alternative therapy.*
We present the report of trismus due to hyperadrenocorticism-associated myotonia diagnosed by electromyography in a dog. An intact female Miniature Dachshund, 13 years and 9 months old, presented with stiff gait and trismus as well as polyuria and polydipsia. Abdominal ultrasonography showed enlarged adrenal glands.
View Article and Find Full Text PDFCanine degenerative myelopathy (DM) is an adult-onset progressive and fatal neurodegenerative disorder. Superoxide dismutase 1 (SOD1) mutations have been reported in affected dogs and immunohistochemical analyses revealed the accumulation of mutant SOD1 (E40K) in spinal neurons and astrocytes. Therefore, this disease is regarded as a unique spontaneous large-animal model of SOD1-mediated amyotrophic lateral sclerosis (ALS) in humans.
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