Publications by authors named "Shunta Goto"
Article Synopsis
- Vitamin C (VitC) is crucial for brain function, and its deficiency leads to neuropsychiatric issues like depression and cognitive decline, but the exact molecular mechanisms are unclear.
- RNA sequencing in ODS rats revealed that short-term VitC deficiency alters gene expression related to glucocorticoid receptors, with increased glucocorticoid secretion from the adrenal gland.
- VitC deficiency also triggers microglial activation and inflammation in the brain, reduces the generation of new neurons, and suggests the necessity of VitC for adult neurogenesis critical for learning and memory.
