Publications by authors named "Shunsuke Nishimoto"

Article Synopsis
  • Peripheral nerve injuries are common with serious consequences, and this study investigates the potential benefits of Neurotropin® (NTP) on nerve regeneration.
  • The study utilized various methods, including in vitro tests on DRG neurons and an in vivo rat model of sciatic nerve injury, to assess the effects of NTP on nerve recovery.
  • Results indicated that NTP enhances axonal outgrowth and significantly improves motor and sensory functions after injury, suggesting its dual role in pain relief and promoting peripheral nerve regeneration.
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  • The study focuses on exploring the link between vitamin D deficiency and the severity of distal radius fractures (DRFs) in women over 45 years old.
  • It found that patients with severe fractures (articular comminuted) had significantly lower levels of serum 25-hydroxyvitamin-D compared to those with less severe fractures.
  • The researchers concluded that vitamin D supplementation could potentially help prevent more severe types of fractures due to its association with lower vitamin D levels.
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 Ulnar shortening osteotomy of the diaphysis is a common and effective surgical procedure for ulnar abutment syndrome. However, this procedure has some disadvantages, such as a long period until union and a relatively high nonunion rate. To overcome these disadvantages, we have developed distal ulnar metaphyseal wedge osteotomy.

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Ultra-fine bubbles (<200 nm in diameter) have several unique properties and have been tested in various medical fields. The purpose of this study was to investigate the effects of oxygen ultra-fine bubbles (OUBs) on a sciatic nerve crush injury (SNC) model rats. Rats were intraperitoneally injected with 1.

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  • * The study explored how NTP influences Schwann cells (SCs), which are crucial for peripheral nerve healing, showing that it boosts certain protein activities and promotes myelination in SCs, particularly in a co-culture with neurons.
  • * Experimenting with rats, researchers found that NTP improved myelination and various nerve functions after inducing nerve damage, suggesting it could be a valuable therapy for nerve injuries and related diseases.
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Unlabelled: Peripheral nerve injury is one of common traumas. Although injured peripheral nerves have the capacity to regenerate, axon regeneration proceeds slowly and functional outcomes are often poor. Pharmacological enhancement of regeneration can play an important role in increasing functional recovery.

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Article Synopsis
  • Neuropathic pain from nerve damage is a tough-to-treat condition, and Neurotropin is a drug commonly used in Japan and China to manage it.
  • The study found that Neurotropin lowers inflammation markers (IL-1β, IL-6, TNF-α) and inhibits Erk activation in the sciatic nerve after injury, suggesting it has local beneficial effects.
  • Additionally, Neurotropin helps preserve myelin basic protein levels, which could lead to new treatment strategies for neuropathic pain and nerve-related injuries.
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Schwann cells (SCs) are constituents of the peripheral nervous system. The differentiation of SCs in injured peripheral nerves is critical for regeneration after injury. Methylcobalamin (MeCbl) is a vitamin B12 analog that is necessary for the maintenance of the peripheral nervous system.

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Al-substituted 11Å-tobermorite was formed by alkaline hydrothermal treatment of blast furnace slag with sodium silicate added at 180°C for 2-48 h. Effects of the hydrothermal treatment time were characterized by XRD, SEM, and isothermal adsorption of N2. Sorption characteristics of the obtained samples were examined for Cs(+) and Sr(2+).

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Methylcobalamin (MeCbl) is a vitamin B12 analog that has some positive effects on peripheral nervous disorders. Although some previous studies revealed the effects of MeCbl on neurons, its effect on the muscle, which is the final target of motoneuron axons, remains to be elucidated. This study aimed to determine the effect of MeCbl on the muscle.

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The photoinduced wettabilities of water, n-hexadecane, dodecane, and n-heptane on a flat TiO2 surface prepared by a sol-gel method-based coating were investigated. An amphiphilic surface produced by UV irradiation exhibited underwater superoleophobicity with an extremely high static oil contact angle (CA) of over 160°. The TiO2 surface almost completely repelled the oil droplet in water.

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A coaxial nanohybrid consisting of a single-walled carbon nanotube (SWCNT), fullerodendron, and SiO(2) shows high-efficiency light-driven hydrogen evolution from water. Upon visible light irradiation, SWCNT/fullerodendron/SiO(2) coaxial nanohybrid shows hydrogen evolution activity in the presence of methyl viologen (MV(2+)), benzyldihydronicotinamide (BNAH), and a colloidal polyvinyl alcohol(PVA)-Pt.

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W-doped TiO(2) nanofibers with various compositions (W/Ti: 2-8%) were fabricated by the electrospinning method from respective precursor solutions containing tungsten(V) pentaethoxide, titanium tetraisopropoxide (TTIP), and polyvinylpyrrolidone (PVP), followed with calcination at 550 °C. Morphological and structural characteristics of these nanofibers were studied with SEM, XRD and XPS. W-doping inhibited the crystal growth and anatase-to-rutile transformation of TiO(2) nanofibers.

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Article Synopsis
  • A new process for creating superhydrophilic-superhydrophobic patterns on titanium oxide (TiO2) surfaces combines inkjet printing and UV-induced decomposition of self-assembled monolayers.
  • The technique involves oxidizing a titanium substrate to enhance its roughness, making it ideal for forming wettability patterns.
  • Importantly, the substrate can be regenerated and re-patterned using the same photocatalytic method, making this approach eco-friendly and sustainable.
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  • A renewable pattern combining superhydrophobic and superhydrophilic properties is created using octadecyltrimethoxysilane on a titanium dioxide surface.
  • The process involves self-assembly and calcination of boehmite particles to form aluminum oxide (Al2O3) overlayers that measure at least 50 micrometers.
  • The resulting Al2O3 layer serves both as a superhydrophobic barrier and a UV-blocking protection for the underlying TiO2 surface.
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  • The text details a fabrication method for creating superhydrophilic and superhydrophobic patterns on titanium substrates, utilizing ink-jet printing and a photocatalytic process involving TiO(2) under UV light.
  • The resulting titanium substrate is shown to function effectively as a high-resolution offset printing plate, capable of achieving 133 and 150 lines per inch.
  • Additionally, the patterns can be refreshed multiple times without losing image quality, as the previous patterns can be completely removed through photocatalytic decomposition.
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Highly ordered TiO2 nanotube array prepared by electrochemical anodization generates considerable interest as a practical air purifier, since a nanotube array can form a TiO2 film with a porous surface and straight gas diffusion channel, simultaneously reserving enough geometric thickness. Here, we reported on the application of highly ordered TiO2 nanotube arrays with different lengths for degradation of gaseous acetaldehyde pollutants in air. The results showed that increasing the lengths of nanotube arrays within a certain range could significantly improve the degradation rate of acetaldehyde molecules.

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A transparent superhydrophobic TiO2 film, prepared by spin-coating a TiO2 slurry on a glass substrate and modifying the resultant TiO2 film with fluoroalkylsilane molecules, was patterned by illumination with ultraviolet light through a photomask, producing a superhydrophobic/superhydrophilic surface micropattern with very small superhydrophilic areas, which we were able to selectively fill with alginate hydrogel.

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Article Synopsis
  • A layer-by-layer assembly technique was used to create novel TiO2 nanostructures that combine anatase nanoparticles with rutile nanorods, enhancing their properties.
  • The process involves using an electrostatic deposition method with a polymeric bridging layer, which is later removed through calcination, allowing for control over the anatase-to-rutile ratio.
  • These new heterogeneous structures exhibited superior photocatalytic activity for breaking down gaseous acetaldehyde compared to the individual anatase and rutile components, attributed to their synergistic effects.
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Heat treatment of various compositions of AgNO(3)-doped polyvinylpyrrolidone (PVP) composite nanofibres fabricated by electrospinning produced two kinds of silver species: (i) Ag nanoparticles dispersed in PVP nanofibres, when the loading of AgNO(3) was 5 wt%, and (ii) a net-like silver nanofibre film when the loading of AgNO(3) was five times greater than that of PVP in the composite nanofibres. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV-visible absorption spectroscopy, FT-IR spectra, powder x-ray diffraction (XRD) and x-ray photoelectron spectroscopy (XPS) were used to characterize the silver nanoparticles and nanofibres. The formation mechanisms are discussed based on the redox reaction between AgNO(3) and PVP during heat treatment; essentially, the weight ratios of AgNO(3) to PVP determined the types of morphologies, from Ag nanoparticles to silver nanofibre film.

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We present here a facile method for the preparation of TiO2-based superhydrophobic surfaces. It consists of two steps: (1) roughening of the TiO2 surface with a rf (radio frequency) plasma with CF4 as an etchant and (2) modification of the roughened TiO2 surface with an octadodecylphosphonic acid (ODP) monolayer. Plasma etching caused the thinning of the TiO2 film but at the same time enhanced its surface roughness.

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