Publications by authors named "Shunsuke Kasai"
Aim: Robotic total mesorectal excision (TME) with resection of adjacent organs has been increasingly used for locally advanced rectal cancer; however, few studies have focused on robotic TME with partial prostatectomy. Therefore, this study aimed to demonstrate the advantages of robotic TME with partial prostatectomy compared with open surgery for rectal cancer.
Method: This retrospective cohort study examined consecutive patients with rectal cancer who underwent robotic or open TME with partial prostatectomy at a high-volume center in Japan from April 2003 to March 2022.
Article Synopsis
- * A 68-year-old man with NF1 had multiple small intestinal GISTs causing anemia and underwent surgery to remove them; two years later, he developed an enlarging mass in the appendix that was surgically removed due to concerns about its potential malignancy.
- * Post-surgery, the diagnosis of an appendiceal neurofibroma was confirmed, highlighting the challenge in identifying these lesions preoperatively and stressing the importance of surgical
Article Synopsis
- This study looked at patients with Stage II colorectal cancer to understand why some people get better and some have a relapse.
- They found that certain genetic changes and features in tumors, like how they grow, can affect a person's chances of staying cancer-free after treatment.
- By studying these factors, doctors might be able to choose better treatments for patients and help them avoid coming back to the hospital for more problems.
Article Synopsis
- The study investigates risk factors for lateral lymph node metastasis in rectal cancer and aims to improve diagnostic accuracy using machine learning models.
- It analyzed data from patients who underwent lymph node dissection without prior treatment across 15 Japanese hospitals from 2017 to 2019, focusing on preoperative factors and MRI findings.
- Results identified key risk factors and developed machine learning models, showing that poorly differentiated adenocarcinoma and certain tumor characteristics significantly increase the likelihood of metastasis.
Tumor lysis syndrome (TLS) is a fatal complication associated with chemotherapy. We herein report a case of TLS in a 73-year-old woman with metastatic BRAF mutated colon cancer after she received combined treatment with cetuximab and encorafenib. The serum uric acid, urea nitrogen, and creatinine levels were elevated on day four of the first cycle.
View Article and Find Full Text PDFBackground: Stoma prolapse (SP) is a common stoma-related complication, particularly in loop colostomies. This study aimed to investigate potential risk factors for SP development after laparoscopic loop colostomy.
Methods: In total, data from 140 patients who underwent laparoscopic loop colostomy were analyzed between September 2016 and March 2022.
Article Synopsis
- The study investigates the relationship between molecular profiles of rectal cancer and the occurrence of lateral lymph node metastasis (LLNM).
- Researchers analyzed data from 123 patients who underwent surgery for rectal cancer, finding that while mutation rates in key genes were similar between those with and without LLNM, a specific consensus molecular subtype (CMS4) was more prevalent in the LLNM-positive group.
- The findings suggest that lymph node size (≥6.0 mm) and CMS4 are strong indicators of LLNM, with their combination offering a high sensitivity for diagnosis.
Aim: This study was undertaken to evaluate the long-term outcomes of staged liver resection for synchronous liver metastases (SLM) from colorectal cancer (CRC), and to elucidate the prognostic impact and predictors of early recurrence (ER), which was defined as recurrence within 6 mo.
Methods: Patients with SLM from CRC, except for initially unresectable SLM, from January 2013 to December 2020 were included. First, overall survival (OS) and relapse-free survival (RFS) after staged liver resection were evaluated.
Purpose: The purpose of this study was to evaluate the long-term outcomes of robotic rectal cancer surgery and to examine the risk factors for recurrence.
Methods: In a high-volume center in Japan, we retrospectively enrolled patients with pStage I-III rectal cancer within 15 cm of the anal verge who underwent robotic surgery from 2011 to 2017. Almost all patients underwent upfront surgery, and lateral lymph-node dissection (LLND) was performed for patients with locally advanced lower rectal cancer.
Purpose: Surgeons should provide patients with appropriate explanations before surgery and obtain informed consent. However, this process requires time and effort and can be a great burden. The purpose of this study was to compare preoperative counseling with video (VC) and conventional counseling (CC) for rectal cancer patients.
View Article and Find Full Text PDFAim: Accurate preoperative diagnosis of lateral lymph node metastasis (LLNM) from lower rectal cancer is important to identify patients who require lateral lymph node dissection (LLND). We aimed to create an effective prediction model for LLNM using machine learning by combining preoperative information.
Methods: We retrospectively examined patients who underwent primary rectal cancer surgery with unilateral or bilateral LLND between April 2010 and March 2020 at a single institution.
Purpose: Although robotic surgery for rectal cancer can overcome the shortcomings of laparoscopic surgery, studies focusing on abdominoperineal resection are limited. The aim of this study was to compare the operative outcomes between robotic and laparoscopic abdominoperineal resection.
Methods: This retrospective cohort study was conducted from April 2010 to March 2020.
Article Synopsis
- The study aimed to assess the impact of robotic staplers on the occurrence of symptomatic anastomotic leakage in patients undergoing robotic low anterior resection for rectal cancer.
- A total of 427 patients were analyzed, out of which 168 pairs of cases using manual and robotic staplers were compared after matching for similar characteristics.
- Results showed that the rate of anastomotic leakage was significantly lower with robotic staplers (1.2%) compared to manual staplers (6.5%), highlighting robotic staplers as beneficial in reducing leakage risk.
We present a very rare case of rectal cancer in a patient with situs inversus totalis (SIT), which is a complete transposition of the thoracic and abdominal viscera. A woman in her 60s visited a local hospital reporting bloody stool and was diagnosed with upper rectal cancer and SIT. We made careful preoperative preparations for the congenital anomaly, and robotic-assisted high anterior resection with D3 lymph node dissection was performed.
View Article and Find Full Text PDFThis study aimed to assess changes in antimicrobial susceptibilities of subgingival bacteria in acute periodontal lesions following systemic administration of a new-generation fluoroquinolone, sitafloxacin and to monitor the occurrence and fate of quinolone low-sensitive strains. Patients with acute phase of chronic periodontitis were subjected to microbiological assessment of their subgingival plaque samples at baseline (A1). Sitafloxacin was then administered systemically (100 mg/day for 5 days).
View Article and Find Full Text PDFThe aim of this study was to assess the effect(s) of systemic administration of sitafloxacin on subgingival microbial profiles of acute periodontal lesions. Antimicrobial susceptibility of clinical isolates was also investigated. Patients with acute phases of chronic periodontitis were subjected to clinical examination and microbiological assessment of their subgingival plaque samples by culture technique.
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