Comparative Effectiveness Analysis of Lumpectomy and Mastectomy for Elderly Female Breast Cancer Patients: A Deep Learning-based Big Data Analysis.

: To evaluate the comparative effectiveness of treatments, a randomized clinical trial remains the gold standard but can be challenged by a high cost, a limited sample size, an inability to fully reflect the real world, and feasibility concerns. The objective is to showcase a big data approach that takes advantage of large electronic medical record (EMR) data to emulate clinical trials. To overcome the limitations of regression analysis, a deep learning-based analysis pipeline was developed.

Aligned deep neural network for integrative analysis with high-dimensional input.

Objective: Deep neural network (DNN) techniques have demonstrated significant advantages over regression and some other techniques. In recent studies, DNN-based analysis has been conducted on data with high-dimensional input such as omics measurements. In such analysis, regularization, in particular penalization, has been applied to regularize estimation and distinguish relevant input variables from irrelevant ones.

Solving the overlapped absorbance profile in gas detection by Lorentz distribution solution based on direct absorption spectroscopy method.

A novel method of Lorentz distribution solution (LDS) from overlapped absorbance profile in time domain (incomplete absorbance profile in frequency domain) based on the direct absorption spectroscopy method (DAS) was experimentally demonstrated. It utilized the ratio of the integral in a certain interval on the lower horizontal axis of the Lorentzian profile to the integral in the entire interval on the horizontal axis has a certain relationship and can be expressed by a formula. This method effectively solves the difficulties of extracting gas concentration from incomplete absorbance profile.

Transverse mode locking of different frequency-degenerate families based on annular beam pumping.

Optical vortex arrays have been achieved in an end-pumped : laser pumped by an annular beam. Spontaneous transverse mode locking of Laguerre-Gaussian modes in different frequency-degenerate families has been obtained by merely adjusting the pump power. A maximum output power of 0.

Hemoglobins Likely Function as Peroxidase in Blood Clam Hemocytes.

Hemoglobins are a group of respiratory proteins principally functioning in transport of oxygen and carbon dioxide in red blood cells of all vertebrates and some invertebrates. The blood clam is one of the few invertebrates that have hemoglobin-containing red hemocytes. In the present research, the peroxidase activity of hemoglobins (Tg-Hbs) was characterized and the associated mechanism of action was deciphered via structural comparison with other known peroxidases.