Development of Pancreatic Acinar Cell Metaplasia During Gastric Repair in a Rat Duodenal Contents Reflux Model.

Background: We previously reported the development of pancreatic acinar cell metaplasia (PACM) in the glandular stomach of a duodenal contents reflux model (reflux model).

Aims: We aimed to investigate the characteristics and histogenesis of PACM using a reflux model.

Methods: A reflux model was created using 8-week-old male Wistar rats, which were killed up to 30 weeks postoperatively.

Barretts's carcinogenesis.

Barrett's esophagus is considered a precancerous lesion of esophageal adenocarcinoma (EAC). Long-segment Barrett's esophagus, which is generally associated with intestinal metaplasia, has a higher rate of carcinogenesis than short-segment Barrett's esophagus, which is mainly composed of cardiac-type mucosa. However, a large number of cases reportedly develop EAC from the cardiac-type mucosa which has the potential to involve intestinal phenotypes.

Host factors influence Barrett's carcinogenesis: findings from a mouse gastroduodenal reflux model.

Background: Rat gastroduodenal reflux models have been used for analyzing Barrett's carcinogenesis. Mice seem to be more useful than rats for studies targeting genes.

Methods: We induced gastroduodenal contents reflux by esophagojejunostomy using C57BL/6J mice.

Metastatic colorectal cancer responsive to regorafenib for 2 years: a case report.

Background: Regorafenib is an oral multikinase inhibitor that has been demonstrated as clinically effective in patients with metastatic colorectal cancer in phase III studies. Although disease control was achieved in 40% of the pretreated patients with metastatic colorectal cancer in the pivotal studies, radiological response has rarely been reported. Severe adverse events associated with regorafenib are known to occur during the first and second courses of treatment.